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Chattopadhyay N, Jeong KH, Yano S, Huang S, Pang JL, Ren X, Terwilliger E, Kaiser UB, Vassilev PM, Pollak MR, Brown EM: Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: Potential impact on reduced GnRH neuron population in CaR-null mice. American Journal of Physiology Endocrinology and Metabolism 929: E523-532, 2007 Yano S, Yamaguchi T, Kanazawa I, Ogawa N, Hayashi K, Yamauchi M, Sugimoto T: Uremic toxin, phenylacetic acid, inhibits osteoblastic proliferation and differentiation: an implication for the pathogenesis of low turnover bone in chronic renal failure. Nephrology Dialysis and Transplantation 22: 3160-3165,2007 Yamamoto M, Yamaguchi T, Yamauchi M, Kaji H, Sugimoto T: Bone mineral density is not sensitive enough to assess the risk of vertebral fractures in type 2 diabetic women. Calcifid Tissue International 80(6): 353-358, 2007 Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T: Serum insulin-like growth factor-I level is associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes mellitus. Osteoporosis International 18: 1675-1681, 2007 Kanazawa I, Yamamoto M, Yamaguchi T, Yamauchi M, Yano S, Sugimoto T: A case of magnesium deficiency associated with insufficient parathyroid hormone action and severe osteoporosis. Endocrine Journal 54(6): 935-940, 2007 Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Yamamoto M, Sugimoto T: Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. BMC Cell Biology 8: 51-62, 2007 Ogawa N, Yamaguchi T, Yano S, Yamauchi M, Yamamoto M, Sugimoto T: The combination of high glucose and advanced glycation end-products (AGEs) inhibit the mineralization of osteoblastic MC3T3-E1 cells through glucose-induced increase in the receptor for AGEs. Hormone and Metabolic Research 39: 871-875, 2007 Ogawa N, Yano S, Yamane Y, Nishiki M, Yamaguchi T, Sugimoto T: A case of MPO-ANCA positive IgA nephropathy successfully treated by tonsillectomy. Clinical and Experimental Nephrology 11(4): 326-331, 2007 . CLINICAL CALCIUM17(10): 1567-1573, 2007 . CLINICAL CALCIUM 17(8): 1193-1199, 2007 THE BONE (0914-7047)21(3): 327-331, 2007 . Progress in Medicine 27(10), 2333-2340, 2007 receptor expression and function in oligodendrocyte commitment and lineage progression:Potential impact on reduced myelin basic protein in CaR-null mice. Journal of Neuroscience Research 86(10): 2159-67, 2008 Yano S, Association between Erythropoietin Requirements and Antihypertensive Agents. Nephron Clinical Practice 109(1): c33-c39, 2008 Yamaguchi T: The calcium-sensing receptor in bone. The Journal of Bone and Mineral Yamamoto M, Yamaguchi T, Yamauchi M, Yano S, Sugimoto T: Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism 93(3): 1013-1019, 2008 Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T: Serum DHEA-S level is associated with the presence of atherosclerosis in postmenopausal women with type 2 diabetes mellitus. Endocrine Journal 55(4): 667-675, 2008 Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Sugimoto T: Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression. Biochemical and Biophysical Research Communications 375(3): 414-419, 2008 Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T: Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men. Calcified Tissue International 83(5): 324-331, 2008 Takaoka S, Yamane Y, Nisiki M, Yamaguchi T, Sugimoto T: Primary pulmonary squamous cell carcinoma associated with elevated IL-6, leukocytosis, hypercalcemia, phagocytosis,reactive lyumphadenopathy and glomeruular mesangial cell proliferationvia the production of PTH-rP and G-CSF. Internal Medicine 47(4): 275-279, 2008 Kaji H, Yamauchi M, Chihara K, Sugimoto T: Relationship between endogenous parathyroid hormone hormone and bone metabolism/geometry in female patients treated with glucocorticoid. Hormone and Metabolic Research 40(1): 60-65, 2008. Kaji H, Yamauchi M, Chihara K, Sugimoto T: Glucocorticoid excess affects cortical bone geometry in premenopausal, but not postmenopausal, women. Calcified Tissue International 82(3): 182-190, 2008. Kaji H, Yamauchi M, Nomura R, Sugimoto T: Improved peripheral cortical bone geometry after surgical treatment of primary hyperparathyroidism in postmenopausal women. Journal of Clinical Endocrinology and Metabolism 93(8): 3045-3050, 2008 Inoue Y, Kaji H, Hisa I, Tobimatsu T, Naito J, Iu M-F, Sugimoto T and Chihara K: Vitamin D status affects osteopenia in postmenopausal female patients with primary hyperparathyroidism. Endocrine Journal 55(1): 57-65, 2008 Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T: Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients Proposal of diagnostic criteria using FGF23 measurement. Bone 42: 1235-1239, 2008 Fukumoto S, Namba N, Ozono K, Yamauchi M, Sugimoto T, Michigami T, Tanaka H, Inoue D, Minagawa M, Endo I, Matsumoto T: Causes and differential diagnosis of hypocalcemia-recommendation proposed by expert panel supported by ministry of health, labour and welfare, Japan. Endocrine Journal 55(5): 787-794, 2008 . Osteoporosis Japn 16(2): 319-322, 2008 — Clinical Calcium 18(7): 904-911, 2008 .Medical Practice 25(9): 1588-1593, 2008 . Osteoporosis Japan 16(2): 244-248, 2008 . Osteoporosis Japan 16(2): 199-201, 2008 Yamauchi M, Kaji H and Sugimoto T: The threshold of volumetric bone mineral density from peripheral quantitative computed tomoigraphy for vertebral fractures in women with oral glucocorticoid treatment. The 17th International Bone Mineral Society, Montreal, June 2007 Yamauchi M, Nomura R, Kaji H, Yano S, Yamaguchi T, Sugimoto T: Marked improvement of cortical bone geometry aftwer parathyroidectomy in postmenopausal women with primary hyperparathyroidism. The 29th American Society for Bone Mineral Research, Hawaii, September 2007 Yamamoto M, Yamaguchi T, yamauchi M, Yano S and Sugimoto T: Serum pentosidine level is positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes. The 29th American Society for Bone Mineral Research, Hawaii, September 2007 Kanazawa I, Yamaguchi T, Yano S, yamauchi M, Yamamoto M, Sugimoto T: AMP kinase activator (AICAR) and Rho-kinasse inhibitor (hydroxyfasudil) induce the differentiation and mineralization of osteoblastic MC3T3-E1 cells via inhibiting the mavalonate pathway and enhancing BMP-2 expression. The 29thAmerican Society for Bone Mineral Research, Hawaii, September 2007 Hayashi K, Yamaguchi T, Yano S, Yamauchi M, Yamamoito M, Sugimoto T: Glucocorticoid suppresses the differentiation of osteoblasts by enhancing the expression of BMP antagonists, follistatin and danm and pretreatment with alendronate and PTH abolish this process. The 29th American Society for Bone Mineral Research, Hawaii, September 2007 septic enchalopathy, critical illness neuropathy Yamamoto M, Yamaguchi T, Yamauchi M, Yano S, Sugimoto T: Undercarboxylated osteocalcin/osteocalcin ratio is negatively associated with hyperglycemic conditions, but not with the presence of vertebral fractures, in patients with type 2 diabetes. The 2ned Joint Meeting of the International Bone & Mineral Society & the Australian & New Zealand Bone and Mineral Society, Sydney, March 2008 Hayashi K, Kurioka S,Kanazawa I,Takase H,Yamamoto M, Wada A, Kitagaki H, Oguro H, Nagai A, Bokura H, Yamaguchi S, Yamaguchi T, Sugimoto T: The Association of Cognitive Dysfunction with Hippocampal and Brain Atrophy in Japanese Elderly Patients with Type 2 Diabetes. American Diabetes Association 68th Scientific Sessions, San Francisco, June 2008 Yamaguchi T, Hayashi K, Yano S, Yamauchi M, Yamamoto M, Sugimoto T: BMP/Wnt antagonists are upregulated by dexamethasone in osteoblasts and reversed by alendronate and PTH: Potential therapeutic targets for glucocorticoid-induced osteoporosis. The 30th American Society for Bone and Mineral Research, Montreal, Canada, September 2008 Yano S, Yamaguchi T, Suzuki K, Sumi M, Himeno Y, Sugimoto T: Acute change in serum ionized calcium directly affects bone formation independent of PTH action during hemodialysis. The 30th American Society for Bone and Mineral Research, Montreal, Canada, September 2008 Kanazawa I, Yamaguchi T, Yano S, Hayashi K, Yamauchi M, Sugimoto T: Inhibition of the mevalonate pathway rescues the dexamethasone-induced suppression of the mineralization of osteoblastic cells. The 30th American Society for Bone and Mineral Research, Montreal, Canada, September 2008 Nawata K, Yamauchi M, Takaoka S, Imaoka M, Kageyama A, Yamaguchi T, Sugimoto T: Association of n-3 Polyunsaturated Fatty Acid Ingestion with Bone Mineral Density in postmenopausal women. The 15th International Congress of Diererics, Tokyo, September 2008 Nawata K, Yamauchi M, Takaoka S, Imaoka M, Kageyama A, Yamaguchi T, Sugimoto T: Ingestion of n-3 Polyunsaturated Fatty Acid is Positively Associated with Bone Mineral Density in Postmenopausal Women. 2008 International Conference on Osteoporosis and Bone Research, Beijing, China, October 2008

Source: http://www.med.shimane-u.ac.jp/gyoseki/paper13/igaku-18.pdf

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END-OF-LIFE CARE END-OF-LIFE CARE IN GENERAL PRACTICE IN GENERAL PRA IN GENERAL PRA IN GENERAL PRA IN THE NETHERLANDS CTICE IN THE NETHERLANDS Sander Bor Sander Borgsteede END-OF-LIFE CARE IN GENERAL PRACTICE IN THE NETHERLANDS Sander Borgsteede The study presented in this thesis was performed at the EMGO Institute at the Depart-ment of Public and Occupationa

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