Machine guarding

LSU Health Sciences Center
New Orleans
Environmental Health & Safety Policy Manual
High Hazard Chemical Policy
PURPOSE:
To minimize hazardous exposures to high hazard chemicals which include select carcinogens, reproductive/developmental toxins, chemicals that have a high degree of toxicity. The procedures provide guidance to all LSUHSC personnel who work with high REPONSIBILITIES:

Environmental Health and Safety (EH&S) shall:
• Provide technical assistance with the proper handling and safe disposal of • Maintain a list of high hazard chemicals used at LSUHSC, see Appendix A. • Conduct exposure assessments and evaluate exposure control measures as necessary. Maintain employee exposure records. • Provide emergency response for chemical spills. Principle Investigator (PI) /Supervisor shall:
• Develop and implement a laboratory specific standard operation plan for high
• Notify EH&S of the addition of a high hazard chemical not previously used in • Ensure personnel are trained on specific chemical hazards present in the lab. • Maintain Material Safety Data Sheets (MSDS) for all chemicals, either on the LSU Health Sciences Center
New Orleans
• Coordinate the provision of medical examinations, exposure monitoring and Employees:
• Complete all necessary training before performing any work.
• Observe all safety rules and regulations.
• Know where the chemical spill kit, fire extinguishers, emergency showers and
• Immediately report unsafe or unhealthy work conditions and any mishaps. IMPLEMENTATION:
General Operating Procedures:
The OSHA Laboratory Standarrequires that special
handling procedures be employed for certain chemicals identified as “particularly
hazardous substances.” Particularly hazardous substances are high hazard
chemicals, which include select carcinogens, reproductive/developmental toxins,
and chemicals that have a high degree of acute toxicity.
Handling:
• Only laboratory personnel trained to work with high hazard chemicals shall perform the work within the designated area. • Designated areas (e.g., chemical hoods, biological safety cabinets, lab benches, outside rooms, etc.) for material use must be established and the area identified by signs or postings. For more information on signs and labeling see • Written procedures for the safe use of the material, waste removal and decontamination procedures must be established prior to use. • When working with high hazard chemicals of moderate/high chronic or high toxicity, maintain records of the date the chemical was used, the amount of chemical used, names of users, and the disposal dates. • When working with chemicals of high chronic toxicity, decontaminate the designated working area before normal work is resumed • If a vacuum line is used, protect the vacuum line with an absorbent liquid or liquid trap and HEPA filter. If a volatile high hazard chemical is used, use a separate vacuum pump or other device placed in a chemical fume hood. LSU Health Sciences Center
New Orleans
• Work surfaces, including chemical fume hoods and biological safety cabinets, should have a removable liner of absorbent plastic-backed paper to help contain spilled materials and to simplify subsequent cleanup and disposal. • Use double containment to protect against spills and breakage when moving a high hazard chemical out of a laboratory to another location. Personal Protective Equipment (PPE):
• Consult the MSDS for recommendations. EH&S is available for additional • At a minimum, goggles/safety glasses with side shields, laboratory coats, and • When methods for decontaminating clothing are unknown, disposable • Gloves must be selected on the basis of their chemical resistance to the material being handled, their suitability for the procedures being conducted, and their resistance to wear and temperature extremes. • If a respirator is required, contact EH&S in advance. The wearing of a respirator requires medical clearance, a fit test and training. Ordering and Storage:
• Only the minimum quantity of the high hazard chemical necessary to conduct • High hazard chemicals must be stored in a designated storage area which must be clearly marked with the appropriate hazard warning signs. • All high hazard chemical containers must be clearly labeled with the chemical name or mixture components and the appropriate hazard warning information. For more information on signs and labeling see • High hazard chemicals should be stored in unbreakable, well-labeled, • Additional storage precautions (e.g., refrigerator, chemical fume hood, or flammable liquid storage cabinet) may be required for certain compounds based upon other properties. For more information on chemical storage see LSU Health Sciences Center
New Orleans
Disposal:
• Place dry materials contaminated with a high hazard chemical in a secure plastic bag. Liquid waste should be placed in containers that are in good condition and have tight fitting lids. • Label the contaminated waste material with the following: o The principle chemical constituents and the approximate percentage of o The date the waste was first placed in the container. • Submit a service request to EH&S for removal. • For more information on chemical waste disposal see Medical Surveillance
Medical surveillance may be required if:
• Significant quantities of high hazard chemicals are used on a regular basis.
• An individual develops signs or symptoms associated with a hazardous
• Where airborne exposure monitoring reveals an exposure level routinely above the action level (or in the absence of an action level, the Permissible Exposure Limit) for an OSHA regulated substance for which there are exposure monitoring and medical surveillance requirements. • Whenever an event such as a spill, leak, explosion or other occurrences takes place and results in the likelihood of an exposure to a hazardous chemical. Exposure Monitoring
• Regular environmental monitoring is not usually practical in labs because chemicals are typically used for relatively short time periods and in small quantities. However, exposure monitoring as required by 29 CFR 1910.1450 will be provided when: o Significant quantities of hazardous chemicals are used over an extended o When regular use of an OSHA regulated substance is believed to be in excess of an action level (AL) or permissible exposure limits (PEL). AL and PELS for OSHA regulated substances can be found i • When laboratory personnel exhibit signs and symptoms of exposure to chemicals used or stored in their areas. LSU Health Sciences Center
New Orleans
• High hazard chemical spills that occur in the chemical fume hood may be • For all high hazard chemical spills that occur outside the chemical fume hood: o Immediately, notify University Police at 568-8999 and EH&S at 314- o Re-entry to the spill area is not permitted until EH&S responders have cleaned the area and verified that it is safe to reenter the lab. TRAINING
The Principal Investigator/Laboratory supervisor will provide laboratory-specific training to all laboratory workers on chemical hazards before handling, using, or storing high hazard chemicals. Training elements should include how to understand an MSDS, selecting the correct PPE, and proper decontamination and disposal procedures. RECORD KEEPING:

Principal Investigators/Laboratory Supervisors shall keep their employee’s
training records for the current fiscal year and the previous three fiscal years.
EH&S will maintain accurate records of any measurements taken to monitor an
employee exposures required by OSHA 1910.1450, Occupational Exposure to
Hazardous Chemicals in the Laboratories, for the current year plus ten calendar
years.
INSPECTIONS:
PI/Laboratory Supervisor
Recurring assessments of high hazard chemical work and storage areas should be
completed by laboratory personnel, to include a review chemical container and
label integrity, good housekeeping practices, and emergency equipment.
EH&S
Overall compliance will be assessed annually by the Environmental Health and
Safety Department.
LSU Health Sciences Center
New Orleans
DEFINITIONS:
• Action level means a concentration designated in 29 CFR Part 1910 for a
specific substance, calculated as an eight-hour time-weighted average, which initiates certain required activities such as exposure monitoring and medical surveillance. • Acute toxic chemicals are chemicals with a high level of acute toxicity that
have the ability to cause harmful local and systemic effects, or death after a single exposure. In general, acute toxic chemicals have an oral LD50 of <50 mg (rats, per kg), skin contact LD 50 of <200 mg (rabbits, per kg). For inhalation, a median lethal concentration LC50 in air of 200 parts per million by volume or less of gas or vapor, or 2 milligrams per liter or less of mist, fume, or dust, when administered by continuous inhalation for one hour (or less if death occurs within one hour) to albino rats weighing between 200 and 300 grams each. See Appendix B for a list of acute toxic chemicals. • Carcinogens are chemicals or physical agents that cause cancer or tumor
development after repeated or chronic exposure. Their effects only become evident after a long period and may cause no immediate harmful effects. Some examples are Di-methyl mercury, Benzo-a-pyrence, and n-Nitrosodiethylamine. • Chronic Toxicity is when harmful effects are produced through repeated or
continuous exposure to a substance over an extended period of time. Some examples are carcinogens, reproductive toxins, and certain heavy metals. • Lethal Concentration 50 (LC50) is the concentration of an air contaminant
that will kill 50% of the test animals in a group during a single exposure.
• Lethal Dose 50 (LD50) is the dose of a substance or chemical that will kill
50% of the test animals in a group within the first 30 days following exposure. • Permissible Exposure Limit (PEL) is the maximum concentration averaged
over 8 hour to which 95% healthy adults can be repeatedly exposed for 8 hours per day, 40 hours per week. LSU Health Sciences Center
New Orleans
• Reproductive/developmental toxins are substances that cause chromosomal
damage or genetic alterations with lethal or teratogenic effects in a developing fetus or embryo. Some examples are lead compounds, organomercurial compounds, arsenic trioxide, benzene, and formamides. See Appendix C for a list of reproductive/developmental toxins. • Select Carcinogen is any substance found on the following lists:
o The Annual Report on Carcinogens published by the National Toxicity Program, including all the substances listed as “known to be carcinogens” and some substances listed as "reasonably anticipated to be carcinogens”. o All of Group I “Carcinogen to humans” and some in Group 2A and 2B, “reasonably anticipated to be carcinogens” listed by the International Agency for Research on Cancer (IARC) See Appendix D for a listing of Select Carcinogens. REFERENCE
LSU Health Sciences Center
New Orleans

10.0 APPENDICES

• Appendix A, High Hazard Chemicals Used at LSUHSC-NO • Appendix B, Acute Toxic Chemicals List • Appendix C, Reproductive/Developmental Toxins List LSU Health Sciences Center
New Orleans

HIGH HAZARD CHEMICALS USED AT LSUHSC
Acrolein – flammable, toxic
Acrylamides – toxic
Aminopterin - toxic
Arsenic acid – toxic – moisture sensitive
Benzene - flammable
Benzidine based dyes - toxic
Cadmium compounds - toxic
Carbon tetrachloride – toxic
Catechol – toxic, corrosive
Chloroform - toxic
Colchicine - toxic
Cyclophosphamide – toxic
Diaminobenzidine - toxic
Dimethyl sulfate – toxic, corrosive
Dioxane, 1,4- - flammable
Ethylene glycol monomethyl ether
Formaldehyde – flammable, (formalin is not considered flammable)
Hexane - flammable
Hydrazine – corrosive – moisture sensitive
Iodomethane – toxic – moisture sensitive
Lead compounds - toxic
Mercury and mercury compounds - toxic
Nicotine - toxic
Osmium tetroxide - toxic
Phenol – toxic
Phenylmethanesulfonylfluoride – toxic – moisture sensitive
Picrotoxin - toxic
Potassium cyanide – toxic – moisture sensitive
Sodium azide - toxic
Sodium cyanide – toxic – moisture sensitive
Strychnine - toxic
Styrene - flammable
Thiophenol - toxic
Thiosemicarbazide - toxic
Thiourea - toxic
Toluene - flammable
Urethane (ethyl carbamate) - toxic
Warfarin - toxic
LSU Health Sciences Center
New Orleans
ACUTE TOXIC CHEMICALS LIST
Chemical Name
Alternate Names
CAS#_____
Propanal, 2-methyl-2-(methylthio)-, 116-06-3 LSU Health Sciences Center
New Orleans
LSU Health Sciences Center
New Orleans
LSU Health Sciences Center
New Orleans
LSU Health Sciences Center
New Orleans
Phalloidon from Amanita Phalloides 17466-45-4 Isopropylmethanefluorophosphonate 107-44-8 LSU Health Sciences Center
New Orleans
LSU Health Sciences Center
New Orleans
REPRODUCTIVE/DEVELOPMENTAL TOXINS LIST

Chemical Name
CAS#_______

1-(2-chloroethyl)-3-cyclohexyl-1-
Nitrosourea (CCNU)
2, 3, 7, 8-Tetrachlorodibenzo-p- dioxin (TCDD) LSU Health Sciences Center
New Orleans
LSU Health Sciences Center
New Orleans
Ethylene glycol monomethyl ether acetate 110-49-6 Ethylene oxide LSU Health Sciences Center
New Orleans
LSU Health Sciences Center
New Orleans
LSU Health Sciences Center
New Orleans
Tetracycline hydrochloride (internal use) LSU Health Sciences Center
New Orleans
LSU Health Sciences Center
New Orleans
SELECT CARCINOGENS LIST
Aziridine Benz(a)anthracene Benzene Benzidine Benzidine –based dyes (technical grade) Benzo(a)pyrene Benzo(b)fluoranthene Benzo(i)fluoranthene Benzo(k)fluoranthene Benzofuran Benzotrichloride Benzyl violet 4B Beryllium and beryllium compounds Betel quid with tobacco Betel quid without tobacco Bis(2-chloroethyl)-2-napththylamine (Chlornaphazine), N,N-Bis(chloromethyl)ether Bis(bromomethyl)propane-1. 3-diol, 2, 2- Bischloroethyl nitrosourea (BCNU) Bis(chloromethyl) ether Bitumens, extracts of steam-refined and air-refined Bleomycins Bracken fern Bromodichloromethane Butadiene, 1, 3- Butanediol dimethanesulphonate (myleran), 1, 4- Butanediol dimethylsulfonate (myleran), 1, 4- Butylated hydroxyanisole (BHA) Butyrolactone, beta- C.I. Basic Red 9 monohydrochloride Cadmium and certain cadmium compounds Caffeic acid Captafol Carbon black extract Carbon tetrachloride Carrageenan, degraded Catechol Ceramic fibers (respirable size) LSU Health Sciences Center
New Orleans
Chlorambucil Chloramphenicol Chlordane Chlordecone (kepone) Chlorendic acid Chloro-4-(dichloromethyl)5-hydroxy-2(5H)-furanone, 3- Chloroaniline, para Chloroethyl)-3-cyclohexy-1-nitrosourea (CCNU), 1-(2- Chloroethyl)-3-4-methylcyclohexyl-1 nitrosourea, 1-(2- Chlorinated paraffins (C12, 60% Chlorine) Chlorinated toluenes, alpha- Chlornaphazine Chloro-2-methylpropene, 1- Chloro-2-methylpropene, 3- Chloro-o-phenylenediamine, 4- Chloro-ortho-toluidine, para Chloroform Chloromethyl ether Chloromethyl methyl ether (technical gradw) Chlorophenols and their sodium salts Chlorophenoxy herbicides Chloroprene Chlorothalonil Chlorozotocin Chromium compounds, hexavalent CI Acid Red 114 CI Basic Red 9 CI Direct Blue 15 Cisplatin Citrus Red No. 2 Coal tar pitches Coal tars Cobalt and cobalt compounds Cobalt metal with tungsten carbide Cobalt metal without tungsten carbide Cobalt (II) sulfate and other soluble cobalt (II) salts Coffee (bladder) Conjugated estrogens Creosotes Cresidin, para Cupferron Cycasin LSU Health Sciences Center
New Orleans
Cyclophosphamide Cyclosporin A Dacarbazine Danthron (1, 8-dihydroxyanthraquinone) Daunomycin DDT Diacetylbenzidine, N. N- Diaminoanisole, 2, 4- Diaminodiphenyl ether, 4, 4- Diaminotoluene, 2, 4’ Diazoaminobenzene Dibenz(a, h)acridine Dibenz(a, h)anthracene Dibenz(a, j)acridine Dibenzo(a, e)pyrene Dibenzo(a, h)pyrene Dibenzo(a, i)pyrene Dibenzo(a, l)pyrene Dibenzo(c, g)carbazole, 7H- Dibromo-3-chloropropane, 1, 2- Dibromoethane (EDB), 1, 2- Dibromopropan-1-ol, 2, 3- Dichloroacetic acid Dichlorobenzene, para- Dichlorobenzene, 1, 4- Dichlorobenzidene, 3, 3’- Dichloro-4, 4’-diaminodiphenyl ether, 3, 3’- Dichloroethane, 1,2- Dichloromethane (methylene chloride) Dichloropropene (technical grade), 1, 3- Dichlorvos Diepoxybutane Diesel engine exhaust Di(2-ethylhexyl)phthalate Diethyl sulphate Diethylhydrazine, 1, 2- Diethylstilbestrol Diglycidyl resorcinol ether Dihydrosafrole Diisopropyl sulfate Dimethoxybenzidine, 3, 3’- Dimethoxybenzidine (ortho-dianisidine), 3, 3’- LSU Health Sciences Center
New Orleans
Dimethyl Sulphate Dimethylaminoazobenzene, para [(Dimethylamino)methylamino]-5-2-(5-nitro-2, trans-2- Dimethylaniline, 2, 6- (2, 6-xylidene) Dimethylbenzidine, 3, 3’- Dimethylcarbamoyl chloride Dimethylhydrazine, 1, 1- Dimethylhydrazine, 1, 2- Dimethylvinyl chloride Dinitrofluoroanthrene, 3, 7- Dinitrofluoroanthrene, 3, 9- Dinitropyrene, 1, 6- Dinitropyrene, 1, 8- Dinitrotoluene, 2, 4- Dinitrotoluene, 2, 6- Dioctyl phthalate [Di(2-ethylhexyl)phthalate] Dioxane, 1, 4- Direct Black 38 Direct Blue 6 Direct Brown 95 Disperse Blue I Epichlorohydrin Epoxybutane, 1, 2- Erionite Estrogens (not conjugated); estradiol-17 Estrogens (not conjugated; estrone Estrogens (not conjugated); mestranol Estrogens (not conjugated); ethinylestradiol Ethylbenzene Ethyl acrylate Ethyl methanesulphonate Ethyl-N-nitrosourea, N- Ethylene oxide Ethylene thiourea Ethylene dibromide Ethyleneimine Etoposide Etoposide in combination with cisplatin and bleomycin Formaldehyde Formylhydrazino)-4-(5-nitro-2-furyl) thiazole, 2-(2- Fuel oils (residual, heavy) Furan LSU Health Sciences Center
New Orleans
Furyl)-3-(5-nitro-2-furyl)acrylamide], AF-2[2- Fusarium moniliform (toxins derived from) Gallium arsenide Gamma radiation (ionizing radiation) Gasoline Gasoline engine exhausts Glasswool (respirable size) Glu-P-1 (2-amino-6-methyldipyrido[1, 2-a:3’, 2’-d] imidazole) Glu-P-2 (2-aminodipyrido[1,2-a:3’, 2’-d] imidazole Glycidaldehyde Glycidol Griseofulvin HC blue No 1 Heptachlor Hexachlorobenzene Hexachlorocylohexanes Hexachloroethane Hexamethylphosphoramide Hydrazine and hydrazine sulfate Hydrazobenzene Hydroxyanthroquinone, 1- Indeno(1, 2, 3-cd) pyrene Indium phosphide IQ (2-amino-3-methylimidazo[4, 5-f] quinoline] Iron dextran complex Isoprene Kepone (chlordecone) Lasiocarpine Lead Lead acetate and lead phosphate Lead compounds, inorganic Lindane and other hexachlorocyclohexane isomers Magenta (containing CI Basic Red 9) Man-made mineral fibers (glasswool, rockwool, slagwool, and ceramic fibers), respirable size MeA-alpha-C(2-amino-3-methyl-9H-pyrido[2, 3-b] indole) MelQ (2-amino-3, 4-dimethylimidazo[4, 5-f] quinoxaline) Medroxyprogesterone acetate Melphalan LSU Health Sciences Center
New Orleans
Merphalan Methoxsalen with ultraviolet A therapy (PUVA) Methoxypsoralen, 8- plus ultraviolet radiation Methoxypsoralen, 5- Methyl mercury compounds (methylmercuric chloride) Methyl methanesulphonate Methyl chloromethyl ether Methyl-1-nitroanthraquinone, 2- Methyl-N’-nitro-N-nitrosoguanidine, N- (MNNG) Methyl-N-nitrosourethane, N- Methyl-N-nitrosourea, N- Methylaziridine (propyleneimine), 2- Methylazoxymethanol and its acetate Methylchrysene, 5- Methylene bis (2-methylaniline), 4, 4’- Methylene bis (N,N-dimethyl) benzenamine, 4, 4’- Methylene bis (2-chloroaniline) (MBOCA), 4, 4’- Methylene chloride (dichloromethane) Methylenedianiline, 4, 4’- and its dihydrochloride Methyleugenol Methylthiouracil Metronidazole Michler’s Ketone Mirex Mitoxantrone Mitomycin C Monocrotaline MOPP and other combined chemotherapy for cancer Morpholinomethyl)-3-[5-nitrofurfurylidene) amino]-2-oxazolidinone, 5-( Mustard gas (sulphur mustad) Nafenopin Naphthalene Naphthalamine, alpha- Naphthalamine, beta Neutrons (ionizing radiation) Nickel and certain nickel compounds Niridazole Nitrilotriacetic acid and its salts Nitroacenaphthene Nitroanisole, 2- Nitrobenzene Nitrobiphenyl, 4- LSU Health Sciences Center
New Orleans
Nitrochrysene, 6- Nitrofen Nitrofluorene, 2- Nitrofurfurylidene) amino]-2-imidazolidinone, 1-[(5- Nitro-2-furyl)-2-thiazolyl] acetamide, N-[4-(5- Nitrogen mustard N-oxide Nitrogen mustard hydrochloride Nitrogen mustard Nitrolotriacetic acid and its salts Nitromethane Nitropropane, 2- Nitropyene, 1- Nitropyene, 4- Nitroso-N-ethylurea, N- Nitroso-N-methylurea, N- Nitrosodi-n-butylamine, N- Nitrosodi-n-propylamine, N- Nitrosodiethanolamine, N- Nitrosodiethylamine, N- Nitrosomethylamino)propionitrile, 3-(N- Nitrosomethylamino)-1(3-pyridyl)-1-butanone (NNK), 4-(N- Nitrosomethylethylamine, N- Nitrosomethylvinylamine, N- Norethisterone Ocratoxin A Oestrogen-progestogen therapy, postmenopausal Oestrogens, nonsteroidal Oestrogens, steroidal Oil Orange SS Oral contraceptives, sequential or combined Oxazepam Oxydianiline, 4, 4- Oxymetholone Panfuran S (containing dihydroxymethylfuratrizine) Phenacetin Phenazopyridine hydrochloride Phenobabital Phenolphthalein Phenoxybenzamine hydrochloride Phenyl glycidyl ether Phenytoin Polybrominated biphenyls (PCBs) LSU Health Sciences Center
New Orleans
Polychlorinated biphenyls (PCBs) Polycyclic aromatic hydrocarbons (PAHs) Ponceau MX Ponceau 3R Potassium bromated Procarbazine hydrochloride Progesterone Progestins Propanesultone-propiolactone, 1, 3- Propane sultone, 1, 3- Propiolactone, beta Propylene oxide Propylthiouracil Refractory ceramic fibers Reserpine Riddlelliine Safrole Selenium sulfide Silica (crystalline) Sodium ortho-phenylphenate Sterigmatocystin Streptozotocin Styrene Styrene oxide (styrene-7, 8-oxide) Sulfallate Sulphuric acid Talc containing asbestiform fibers Tamoxifen Tenopiside Tetrachlorodibenzo-p-dioxin (TCDD), 2, 3,7, 8- Tetrachloroethylene (perchloroethylene) Tetrafluorethylene Tetranitromethane Thioacetamide Thiodianiline, 4,4’- Thiotepa [tris(1-azinidinyl) phosphine sulfide] Thiouracil Thiourea Thorium dioxide Toluene diisocyanates Toluidine, ortho- (3, 3-Dimethylbenzidine) Toluidine hydrochloride, ortho- LSU Health Sciences Center
New Orleans
Toxaphene (polychlorinated camphenes) Trans-2[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]- (Treosulphan) Trichloroethylene Trichlormethine (Trimustine hydrochloride) Trichlorophenol, 2, 4, 6- Trichloropropane, 1, 2. 3- Tris(2, 3-dibromopropyl) phosphate Trp-P-1(3-Amino-1, 4-dimethyl-5H-pyrido[4,3-b]indole) Trp-P-2(3-Amino-1-methyl-5H-pyrido[4,3-b]indole) Trypan blue Uracil mustard Urethane Vanadium pentoxide Vinyl acetate Vinyl bromide Vinyl chloride Vinyl fluoride Vinylcyclohexene, 4- Vinylcyclohexene diepoxide, 4- Wood dust Zalcitabine Zidovudine (AZT, retrovir)

Source: http://www.is.lsuhsc.edu/safety/policies/EHS200.09%20-%20High%20Hazard%20Chemical%20Policy.pdf