Material Safety Data Sheet
Ethambutol Hydrochloride MSDS
Section 1: Chemical Product and Company Identification
14025 Smith Rd.
US Sales: 1-800-901-7247
International Sales: 1-281-441-4400
TSCA 8(b) inventory: No products were found.
CHEMTREC (24HR Emergency Telephone), call:
Dadibutol, Myambutol; Ethambutol
International CHEMTREC, call:
For non-emergency assistance, call:
Section 2: Composition and Information on Ingredients
% by Weight
Toxicological Data on Ingredients:
Ethambutol Hydrochloride: ORAL (LD50): Acute: 6800 mg/kg [Rat]. 8900 mg/kg [Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects:
Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of
Potential Chronic Health Effects:
Slightly hazardous in case of skin contact (sensitizer), of ingestion. CARCINOGENIC EFFECTS: Not available. MUTAGENIC
EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The
substance may be toxic to eyes. Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention if irritation occurs.
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water
may be used.
Serious Skin Contact:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Section 5: Fire and Explosion Data
Flammability of the Product:
May be combustible at high temperature.
Products of Combustion:
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2.).
Fire Hazards in Presence of Various Substances:
Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in
presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards:
Special Remarks on Explosion Hazards:
Section 6: Accidental Release Measures
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on
the contaminated surface and dispose of according to local and regional authority requirements.
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the
contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a
fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. If ingested, seek medical advice
immediately and show the container or the label.
Keep container tightly closed. Keep container in a cool, well-ventilated area. Protect from light and moisture.
Section 8: Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
Section 9: Physical and Chemical Properties
Physical state and appearance:
Solid. (Crystalline powder.)
pH (1% soln/water):
Water/Oil Dist. Coeff.:
Ionicity (in Water):
See solubility in water.
Easily soluble in cold water, hot water. Soluble in alcohol.
Section 10: Stability and Reactivity Data
The product is stable.
Conditions of Instability:
Excess heat, light, moisture, incompatible materials
Incompatibility with various substances:
Special Remarks on Reactivity:
Protect from light and moisture
Special Remarks on Corrosivity:
Will not occur.
Section 11: Toxicological Information
Routes of Entry:
Toxicity to Animals:
Acute oral toxicity (LD50): 6800 mg/kg [Rat].
Chronic Effects on Humans:
May cause damage to the following organs: eyes.
Other Toxic Effects on Humans:
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals:
Special Remarks on Chronic Effects on Humans:
May affect genetic material (mutagenic). May cause birth defects (teratogenic) based on animal test data.
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause
respiratory tract irritation. Ingestion: May cause gastrointestinal upset, nausea, vomiting, abdominal pain, and anorexia, pruritis
joint pain. May affect vision(decreases in visual acuity, scotoma, color blindness, and /or visual defect, which appear to be
due to opitic neuropathy including optic neuritis or retrobulbar neuritis), liver, behavior/central nervous system and peripheral
nervous system(hallucinations, dizziness, mental confusion, disorientation, numbness and tingling of the extremities, tremor,
convulsions, headache, fever, malaise), heart, respiration. Chronic Potential Health Effects: Skin: Prolonged May dermatitis,
an allergic reaction. Ingestion: Prolonged or repeated ingestion may cause anaphylactoid (allergic) reactions.
Section 12: Ecological Information
BOD5 and COD:
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation:
The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation:
Section 13: Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
Not a DOT controlled material (United States).
Special Provisions for Transport:
Section 15: Other Regulatory Information
Federal and State Regulations:
No products were found.
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the
European Inventory of Existing Commercial Chemical Substances.
Not controlled under WHMIS (Canada).
R61- May cause harm to the unborn child. S22- Do not breathe dust. S36/37/39- Wear suitable protective clothing, gloves and
eye/face protection. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where
National Fire Protection Association (U.S.A.):
Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.
Section 16: Other Information
Other Special Considerations:
10/09/2005 05:27 PM
11/01/2010 12:00 PM
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Steven M. Hoefflin, M.D., F.A.C.S. Steven M. Hoefflin, M.D., F.A.C.S., graduated first in his class at UCLA Medical School in 1972. He continued his education in general surgery and completed a full plastic surgical residency training program at the UCLA Medical Center, where he received the coveted Surgical Medal Award. He is Board certified by the American Board of Plastic Surgery and is