International Journal p-ISSN: 2075-4124 e-ISSN: 2075-7107 of Academic Research National registration No: 2996 CrossRef DOI: 10.7813/2075-4124.2012 Article DOI: 10.7813/2075-4124.2012/4-4/A.10 Hanan Abd-Allah El-Gamal, Sally Mohamed Saber, Manal Ebrahim El-Hassaneen
Administration of fluconazole as prophylactic systemic antifungal
in very low birth weight preterm neonates
Abstract: Background: Preterm neonates in neonatal intensive care units (NICUs) are highly prone to invasive fungal infection (IFI). Candida species is the third most frequent causal agent of late-onset sepsis (LOS) in preterm neonate very low birth weight. Reducing fungal colonization may prevent the development of IFI of preterm infants. Therefore it is necessary to use antifungal prophylaxis with Fluconazole in order to reduce fungal coloniza- tion and systemic fungal infection in very low birth weight neonates. Objective: To evaluate the effectiveness of prophylactic systemic Fluconazole in preventive fungal colonization and invasion in very low birth weight neonates. Methodology: the study was done on one hundred preterm neonates admitted in NICU Al–Galaa Teaching Hospital during the period from April 2009 to June 2010. Neonates were subdivided into; Group A: 50 VLBW neonates received 3mg/kg Fluconazole intravenous for four weeks, every third day for the first 2 weeks and then every other day during the third and fourth weeks; Group B: 50 VLBW as a control did not receive Fluconazole. For both groups’ baseline and weekly, throat swab, endotracheal aspirate, and blood culture were done. For group A liver function tests were done weekly to assess safety of the drug. Results: The 50 infants randomly assigned to Fluconazole and the 50 control infants were cross matched in terms of birth weight, gestational age at birth and base-line risk factors for fungal infection. During the four weeks treatment period, fungal colonization was detected in 15 infants in control group (30%) and 5 infants in Fluconazole group (10%) (P value 0.012 significant). Invasive fungal infection (proved with positive fungal growth in the blood culture); developed in 5 infants (10%) in the control group and none of infants in Fluconazole group were developed invasive fungal infection (P value 0.022 significant). No adverse effect of Fluconazole therapy was found. Conclusion: Prophylactic administration of Fluconazole during the first four weeks of life is effective in preventing fungal colonization and invasive fungal infection in infant with very low birth weight (1001-1500gms). Keywords: Fluconazole; very low birth weight (VLBW); fungal colonization; invasive fungal infection (IFI) Pages: 70-78 Cite this article:
H. Abd-Allah El-Gamal, S.M. Saber, M.E. El-Hassaneen. Administration of fluconazole asprophylactic systemic antifungal in very low birth weight preterm neonates. InternationalJournal of Academic Research Part A; 2012; 4(4), 70-78.
Efficient Efficient. Flexible. Cost-Effective. Flexible Cost-Effective Introducing the Aeroneb® Professional Nebulizer System An exceptional aerosol delivery option for clinicians that saves time, lowers costs and provides flexibility for respiratory therapy throughout the hospital. The Aeroneb Pro provides effective dose delivery of physician-prescribedinhalation solutions for in
The Burnham Review Diabetes and Manual Therapy Approaches Consider Manual Therapy and Complementary and Alternative Medicine for Optimal Health Kimberly Burnham, PhD Editor vertebral subluxations, therapies include vitamin E,which affec t t he glutathione, folate, pyridoxine,relationship between biotin, myo-inositol, omega-3 and -6the nervous system and fatty acids, L-arginine, L-glu