Table 1: Food and Drug Interactions. Interactions/ Examples1 Guidelines ALLERGIES Antihistamine FOOD: Take without
Fexofenadine/ALLEGRA. Fexofenadine/ALLEGRA
Bioavailability decreases oratadine/CLARITIN
juice. ALCOHOL: Avoid alcohol because it increases the sedative effects of the medications. ARTHRITIS FOOD: For rapid relief,
moderate pain and take on empty stomach.
ALCOHOL: Avoid or limit the use of alcohol because chronic alcohol use can increase the risk of liver damage or stomach bleeding. FOOD: Take with food ALCOHOL: Avoid or limit the use of alcohol because chronic alcohol use can increase the risk of liver damage or stomach bleeding. FOOD: Take with food
itching. • To help relieve allergies, rheumatoid arthritis, and other conditions.
ALCOHOL: Avoid FOOD: High-fat meals
may increase the amount THEO-DUR, UNIPHYL
bronchial asthma, of theophylline in the
decrease it. It is important MIST to check with the pharmacist about which form you are taking because food can have different effects depending on the dose form. CAFFEINE: Avoid eating or drinking large amounts of foods and beverages that contain caffeine. ALCOHOL: Avoid alcohol because it can increase the risk of side effects such as nausea, vomiting, headache and irritability.
To help eliminate FOOD: Take on an VASCULAR DISORDERS
milk to decrease stomach hydrochlorothiazide/
calcium and magnesium. HYDRODIURIL Triamterene is known as a Trimterene/DRYENIUM “potassium sparing”
triamterene avoid eating large amounts of potassium-rich foods such as bananas, oranges and green leafy vegetables or salt substitutes.
FOOD: Take with food to Atenolol/TENORMIN
nerve impulses to increase bioavailability.
separately from orange juice. Avoid licorice. ALCOHOL: Avoid drinking alcohol with propranolol/INDERAL because these drugs lower blood pressure too much. FOOD: Take on an ALCOHOL: Avoid
relaxing effect of nitrates and result in dangerously low blood pressure.
FOOD: Take
angiotension II, a empty stomach. High fat
meals decrease absorption Quinapril/ACCUPRIL
of quinapril/ACCUPRIL. Moexipril/UNIVASC
Take others without regard to food. Ensure adequate fluid intake. Avoid salt substitutes.
FOOD: Avoid
production rate of and simvastatin/ ZOCOR. Simvastatin/ZOCOR LDL (bad)
should be taken with the evening meal to enhance absorption.
ALCOHOL: Avoid drinking large amounts of alcohol because it may increase the risk of liver damage. FOOD: Vitamin K
formation of blood produces blood-clotting clots.
substances and may reduce the effectiveness of anticoagulants. Limit foods high in Vitamin K such as broccoli, spinach, kale, turnip greens, cauliflower, and br ussel sprouts. High doses of vitamin E (400 IU or more) may prolong clotting time and increase the risk of bleeding.
INFECTIONS Antibiotics and
To treat infections GENERAL
caused by bacteria GUIDELINES: Tell the and fungi.
doctor if you experience skin rashes or diarrhea. If you are using birth control, consult with your health care provider because some methods may not work when taken with antibiotics. Be sure to finish all of your medication even if you start feeling better. Take
To treat infections FOOD: Take on an
caused by bacteria empty stomach unless it
upsets your stomach, then AMOXIL take with food.
To treat infections FOOD: Take on empty
caused by bacteria stomach one hour before
or two hours after meals. Ofloxacin/FLOXIN If your stomach gets
upset, take with food, but not with dairy or calcium- fortified products alone. CAFFEINE: Taking these medications with caffeine-containing products may increase caffeine levels, leading to excitability and nervousness.
Cephalosporins To treat infections FOOD:Take on an empty Cefaclor/CECLOR
caused by bacteria stomach one hour before
or two hours after meals. Cefradroxil/DURICEF If your stomach gets
Cefprozil/CEFZIL Cephalexin/KEFLEX,KEFTAB
To treat infections FOOD: May take with
caused by bacteria food if GI distress occurs. Clarithromycin/BIAXIN and fungi.
ERY-TAB, ERYCErythromycin + sulfisoxazole/PEDIAZOLE
To treat infections FOOD: Take with food
caused by bacteria and at least 8 ounces of
To treat infections FOOD:Take on an empty Tetracycline/ ACHROMYCIN, caused by bacteria stomach with 8 ounces of SUMYCIN and fungi.
products, antacids, and vitamin supplements containing iron because they can interfere with the medication’s effectiveness.
To treat infections FOOD: May take with
caused by bacteria food to decrease GI and fungi.
distress, but food decreases bioavailability. ALCOHOL: Avoid drinking alcohol and
taking medications that contain alcohol while taking metronidazole and for at least three days after you finish the medication. Alcohol may cause nausea, abdominal cramps, vomiting, headaches, and flushing.
FOOD: Take with food to Fluconazole/DIFLUCAN increase absorption. Do
X with grapefruit/related citrus. ALCOHOL: Avoid drinking alcohol and taking medications that contain alcohol while taking keroconzole and for at least three days after you finish the medication. Alcohol may cause nausea, abdominal cramps, vomiting, headaches, and flushing. FOOD: These DISORDERS Oxidase (MAO)
anxiety disorders. people taking them need
to follow the dietary guidelines and physician’s instructions very carefully. A rapid, potentially fatal increase in blood pressure can occur if foods or alcoholic beverages containing tyramine are consumed while taking MAO inhibitors. Avoid foods high in tyramine and other pressor amines during drug use and for two weeks after discontinuation. These include aged cheeses, aged meats, soy sauce, tofu, miso, fava beans, snowpeas, sauerkraut, avocadoes, bananas, yeast extracts, raisins, ginseng, licorice, and caffeine. ALCOHOL: Do not drink beer, red wine, other
alcoholic beverages, non-alcoholic and reduced alcohol beer and red-wine products.
FOOD: May take with
food if GI distress occurs. Diazepam/VALIUM
CAFFEINE: May cause
anxiety disorders. excitability, nervousness
and hyperactivity and lessen the anti-anxiety effects of the drugs. ALCOHOL: May impair mental and motor performance. FOOD: These
medications can be taken Sertraline/ZOLOFT
anxiety disorders. ALCOHOL: Avoid FOOD: These mediations Cimetidine/TAGAMET CONDITIONS Blockers CAFFEINE: Caffeine
products may irritate the stomach. ALCOHOL: Avoid alcohol while takingthese products. Alcohol may irriate the stomach and make it more difficult for the stomach to heal.
1The generic name for each drug is stated first. Brand names are in all capital letters and represent only some examples of those medications. References: Food and Drug Interactions, 1998, U.S. Food and Drug Administration, National Consumers League.
Table 2: Aspirin vs. Acetaminophen vs. Ibuprofen Acetaminophen Ibuprofen
Classification
• reduces swelling and inflammation • used to treat arthritis, many other conditions and injuries • used to reduce risk of heart attack and stroke
Cautions
• get stomach irritation when long-term use can cause
taking aspirin-or are allergic liver damage, especially if
• Should not be used to treat • a skin condition called
fever over 103.1° F for more “angioedema”
• Should not be used to treat antiinflammatory medications
gout, asthma, hearing loss. • Should not be used on a
regular basis by people who • Not to be used with aspirin, suffer from: anemia or liver alcohol or steroids. or kidney disease
Recommendations intake/hydration
high dosage use • Avoid or limit garlic, ginger and Gingko, or horse chestnut • Limit caffeine • Avoid alcohol
can’t take aspirin because of than aspirin for some.
because it is associated with aspirin-related allergic
a rare disorder called Reye’s reactions, stomach irritation, ears like aspirin. Syndrome in these age
Known Brands
Aspirin, Ascriptin, Bufferin, Aspirin Free Anacin, Aspirin Advil, Midol IB, Motrin Ecotrin
Free Excedrin, Tylenol, Panadol, Tempra.
Pregnant women should consult a doctor prior to taking any over-the-counter medication. Other people, including persons with medical conditions, are advised to read product labels carefully and consult a pharmacist if they have any questions about proper use. Medical Center of the Rockies. Food & Drug Interactions. 2008
Pronsky, Zm. Food Medication Interactions. 15th Edition. Birchrunville, Pa: 2008 U.S. Food & Drug Adminstration. National Consumers League. Food & Drug Interactions. 1998.
1J. Anderson, Colorado State University Extension foods and nutrition specialist and professor; and H. Hart, associate specialist; food science and human nutrition. 12/96. Revised 12/08.
MEDICATION GUIDE FYCOMPA ™ (fī-COM-puh) (perampanel) Read this Medication Guide before you start taking FYCOMPA and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment. What is the most important information I should know about FYCOMPA? 1. FYCOM
Simultaneous Determination of Rosuvastatin and N-Desmethylrosuvastatin in Human Plasma using Negative Ion ESI-LC/MS/MS Linge Li, William Mylott, Bruce Hidy, and Rand Jenkins • PPD, Richmond, Virginia INTRODUCTION SUMMARY OF BIOANALYTICAL METHOD Calculations Figure 2. Plasma Blank with Internal Standard A bioanalytical method was developed for the Valida