Animalcare Limited Common Road Dunnington York YO19 5RU Tel: +44 (0) 1904 487687 Fax: +44 (0) 1904 487611 BENAZECARE® FLAVOUR 20MG TABLETS
On rare occasions, transient signs of hypotension,
such as lethargy and ataxia may occur, especially at
Presentation
tablets. Each tablet contains 20mg benazepril hydro-
As is routine in cases of chronic renal insufficiency,
it is recommended to monitor plasma creatinine and
After oral administration, benazepril is rapidly
absorbed from the gastrointestinal tract and hydro-
Do not use in pregnant or nursing bitches, or in
lysed into benazeprilat, a highly specific and potent
bitches intended for breeding. Studies in laboratory
inhibitor of angiotensin converting enzyme (ACE).
animals (rats) have shown embryotoxic effects of
Benazeprilat produces significant inhibition of plasma
benazepril at non-maternotoxic doses (urinary tract
ACE activity for more than 24 hours after a single
abnormalities in the foetus). The safety of the product
dose in dogs. Inhibition of ACE leads to a reduced
has not been assessed during pregnancy and lacta-
conversion of inactive angiotensin I into angiotensin
II and therefore reduction in the effects mediated by
Laboratory studies in rats and observations in
angiotensin II, including vasoconstriction of both
humans have produced evidence of teratogenic ef-
arteries and veins, retention of sodium and water by
the kidney and remodelling effects (including patho-
In dogs with heart failure, benazepril has been
given in combination with digoxin, diuretics and anti-
In dogs with heart failure, benazeprilat lowers the
arrhythmic drugs without demonstrable adverse in-
blood pressure and volume loading effect on the
heart. Onset of clinical efficacy can be expected
In healthy dogs overdose up to 200-fold was
approximately 1 week after initiation of treatment
asymptomatic. Transient reversible hypotension may
with benazepril hydrochloride. Benazeprilat is ex-
occur in cases of accidental overdose. Symptomatic
creted equally by both biliary and urinary routes in
treatment should consist of intravenous infusion of
dogs and therefore no adjustment of the dose of the
product is necessary in the treatment of cases with
In man, the combination of ACE inhibitors and
NSAIDs can lead to reduced anti-hypertensive effi-cacy or impaired renal function. The combination of
Dosage and administration
benazepril and other anti-hypertensive agents (e.g.
is 0.25 mg benazepril hydrochloride/kg body weight,
calcium channel blockers, b-blockers or diuretics),
to be given orally once daily. The dose may be
anaesthetics or sedatives may lead to additive hypo-
doubled, still administered once daily, if judged
tensive effects. Therefore concurrent use of NSAIDs
clinically necessary and advised by the veterinary
or other medications with a hypotensive effect should
surgeon. The dosing regime is as follows:
be considered with care. Renal function and signs of
BENAZECARE 20mg
hypotension (lethargy, weakness etc) should be mon-
Weight (kg) Standard dose Double dose
itored closely and treated as necessary.
Interactions with potassium preserving diuretics
like spironolactone, triamterene or amiloride cannot
be ruled out. It is recommended to monitor plasmapotassium levels when using benazepril in combina-
Benazecare can be given with or without food. The
tion with a potassium sparing diuretic as life threat-
Benazepril may be given with digoxin, diuretics and
Contra-indications, warnings, etc
cial care to avoid accidental exposure because ACE
inhibitors have been found to affect the unborn child
Do not use in any dog that has evidence of cardiac
output failure, for example, due to aortic stenosis.
In case of accidental ingestion by children, seek
Do not use in cases of known hypersensitivity to
medical advice immediately and show this label to
the active substance or to any of the excipients. Pharmaceutical precautions Packaging Quantities
taining 14 tablets packed in a cardboard box with a
package leaflet. Benazecare Flavour 20mg tablets are
supplied in packs of 14, 28, 56 or 140 tablets. Not all
Return any halved tablet to the blister pack and use
Keep the blister pack in the outer carton. Further information
Do not use after the expiry date stated on the
benazepril has been observed in dogs during clinical
trials. The biliary excretion of benazepril means there
is little risk of bioaccumulation in dogs with impaired
should be disposed of in accordance with national
Segregation according to household size in a monocentric city by Theis Theisen Abstract Over the last two centuries, household size has decreased considerably. Within a theoretical model I investigate the relationship between household size and the structure and size of cities. Household utility is assumed to depend on household size, in addition to the consumption of housing and a numerai
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