Exploitation of a Candida antarctica lipase B-catalyzed in situ carboxylic acid activation method for the synthesis of acetanilides: Samridhi Lal and Timothy J. Snape,* Journal of Molecular Catalysis B: Enzymatic, 2012, In Press.
Thermodynamic interactions of a cis and trans benzanilide with Escherichia coli bacterial membranes: Sarah R. Dennison, David A. Phoenix and Timothy J. Snape, European Biophysics Journal, 2012,doi:10.1007/s00249- 012-0835-3.
Exploiting conformationally restricted N,N’-dimethyl-N,N’-diarylureas as biologically active C=C double bond analogues: synthesis and biological evaluation of combretastatin A-4 analogues: Timothy J. Snape,* Katherine Karakoula, Farzana Rowther and Tracy Warr, RSC Adv., 2012, 2 (19), 7557 - 7560.
Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure: Andrea March- Cortijos, Timothy Snape* and Nicholas Turner, Synlett, 2012, 23, 1511-1515.
Interactions between suitably functionalised conformationally distinct benzanilides and phospholipid monolayers: Sarah R. Dennison, Zaheer Akbar, David A. Phoenix and Timothy J. Snape,*Soft Matter, 2012, 8 (11), 3258 - 3264.
Exploiting conformationally restricted ureas as biologically active C=C double bond analogues against GBM cells in vitro, TJ Snape, A Karakoula, F Rowther and TJ Warr, Neuro. Oncol., 2011, 13 (suppl 2): ii1-ii14.
Towards establishing the effects and mechanism of action of a series of indoles in an in vitro chemosensitivity system for glioma treatment, Saurabh Prabhu, Frederick Harris, Robert Lea and Timothy J Snape, Neuro. Oncol., 2011, 13 (suppl 2): ii1-ii14.
Effects of Momordica charantia fruit extract with the combination of temozolamide and cisplatin in the treatment of glioma cancer: G. Manoharan, R. W. Lea, T. J. Snape, J. Singh*, Proc. Physiol. Soc., 2010, 18, PC22.
Roberts, Stanley Michael; Santoro, Maria Gabriella; Jadhav, Vasudev; Happe, Alan Michael; Evans, Paul; Ross, Nicolette Christa; Snape, Timothy James, Patent Number: US 07759399, Publication Date: July 20, 2010, Crawford Healthcare Holdings Limited .
Understanding the chemical basis of drug stability and degradation: Timothy J. Snape*, Alison M. Astles and Janice Davies, The Pharmaceutical Journal,2010, 285, 416.
The process of drug development from the laboratory bench to the market: Timothy J. Snape* and Alison M. Astles, The Pharmaceutical Journal,2010, 285, 272.
The rational redesign of penicillins to help combat penicillin resistance: Timothy J. Snape* and Alison M. Astles, The Pharmaceutical Journal,2010, 285,162.
Take a close look at citalopram and you can predict its contraindications: Timothy J. Snape* and Alison M. Astles, The Pharmaceutical Journal,2010, 285, 59 - Cover Article.
Monoamine Oxidase (MAO-N) Catalysed Reactions: Application Towards the Chemo-Enzymatic Deracemisation of the Alkaloid (±)-Crispine A: Andrew J. Ellis, Renate Reiss, Timothy J. Snape and Nicholas J. Turner, Practical Methods for Biocatalysis and Biotransformations, 2009, John Whittall, Peter Sutton (Eds), Wiley, Chapter 11.1.
Towards a chemo-enzymatic method for the asymmetric synthesis of β-amino tertiary alcohols: Andrea March- Cortijos and Timothy J. Snape*, Org. Biomol. Chem., 2009, 7, 5163-5165.
Versatility of a new bioinorganic catalyst: Palladized cells of Desulfovibrio desulfuricans and application to dehalogenation of flame retardant materials, K. Deplanche; T. J. Snape; S. Hazrati; S. Harrad; L. E. Macaskie*, Environmental Technology, 2009, 30, 7, 681–692.
Helix Persistence and Breakdown in Oligoureas of Metaphenylenediamine: Apparent Diastereotopicity as a Spectroscopic Marker of Helix Length in Solution: Jonathan Clayden*, Loic Lemiegre, Gareth A. Morris, Mark Pickworth, Timothy J. Snape and Lyn H. Jones, J. Am. Chem. Soc., 2008, 130, 15193–15202.
α-Arylation of Aryl-Ketones: Expanding the Scope of the Truce-Smiles Rearrangement: Timothy J. Snape*, Synlett, 2008, 2689-2691.
A Truce on the Smiles Rearrangement: Revisiting an Old Reaction – The Truce-Smiles Rearrangement: Timothy J. Snape*, Chem. Soc. Rev., 2008, 11, 2452-2458.
A biogenic catalyst for hydrogenation, reduction and selective dehalogenation in non-aqueous solvents: N. J. Creamer, K. Deplanche, T. J. Snape, I. P. Mikheenko, P. Yong, D. Samyahumbi, J. Wood, K. Pollmann, S. Selenska-Pobell and L. E. Macaskie*, Hydrometallurgy, 2008, 94, 138-143.
Enzymatic desymmetrisation of (2-hydroxymethyl-oxiranyl)-methanol in organic solvents: Andrea March Cortijos and Timothy J. Snape*, Tetrahedron: Asymmetry, 2008, 19, 15, 1761-1763.
Recent Advances in the Semi-Pinacol Rearrangement of α-Hydroxy Epoxides and Related Compounds: Timothy J. Snape*, Chem. Soc. Rev., 2007, 36, 11, 1823-1842.
A Template-Based Mnemonic for Monoamine Oxidase (MAO-N) Catalyzed Reactions and its Application Towards the Chemo-Enzymatic Deracemisation of the Alkaloid (±)-Crispine A: Kevin R. Bailey, Andrew J. Ellis, Renate Reiss, Timothy J. Snape* and Nicholas J. Turner*, Chem. Commun., 2007, 3640-3642. Designated a Chem. Commun. “Hot Article”
Achieving conformational control over C-C, C-N and C-O bonds in biaryls, N,N’-diarylureas and diaryl ethers: advantages of a relay axis: Mark S. Betson, Ann Bracegirdle, Jonathan Clayden*, Madeleine Helliwell, Andrew Lund, Mark Pickworth, Timothy J. Snape and Christopher P. Worrall, Chem. Commun., 2007, 7, 754- 756.
Application of the Semi-Pinacol Rearrangement Towards the Generation of Alkenyl-Substituted Quaternary Carbon Centres: Timothy J. Snape*, Org. Biomol. Chem., 2006, 4, 4144-4148.
Induction of Apoptosis in Estrogen-Receptor Negative Breast Cancer Cells by Natural and Synthetic Cyclopentenones: Role of the IKK/NF-κB Pathway: Ciucci A, Gianferretti P, Piva R, Guyot T, Snape TJ, Roberts SM and Santoro MG*, Mol. Pharmacol., 2006, 70, 1812-1821.
Synthesis of 4-azacyclopent-2-enones and 5,5-dialkyl-4-azacyclopent-2-enones: Dauvergne J, Happe AM*, Jadhav V, Justice D, Matos MC, McCormack PJ, Pitts MR, Roberts SM, Singh SK, Snape TJ, Whittall J, Tetrahedron, 2004, 60, 2559-2567.
Synthesis and revision of the stereochemistry of a cyclopentenone natural product isolated from ascomycete strain A23-98:Bickley JF, Roberts SM, Santoro AG, Snape TJ*, Tetrahedron, 2004, 60, 2569-2576.
The IκB kinase IKK is the molecular target for anti-herpetic cyclopentenones: Amici C, Belardo G, Ciucci A, Volpi C, Guyot T, Evans P, Happe A, Snape T, Roberts S, Santoro MG*, Antiviral Research, 2003, 57, 3, A58-A58.
Roberts Stanley Michael; Ross Nicolette Christa; Jadhav Vasudev; Evans Paul; Snape Timothy James; Happe Alan Michael; Santoro Gabriella Maria, Patent Number: AU2003224244, Publication Date: 2003-10-13, Charterhouse Therapeutics Ltd.
FEATURES May 13, 2010, 5:00PM EST Forest Laboratories' Globe- Trotting Profits From New York to Dublin, through Amsterdam to Bermuda—how one pharmaceutical company avoids a third of its U.S. income taxes by moving its money around the world With a swipe of his debit card in a Phoenix pharmacy, Tyler Hurst bought a $99 bottle of Lexapro and kicked off a 9,400-mile odyssey of internati
DOI: 10.1111/j.1468-1293.2008.00664.xHIV Medicine (2009), 10, 152–156Impact of a modified directly administered antiretroviraltreatment intervention on virological outcome inHIV-infected patients treated in Burkina Faso and MaliCM Pirkle,1 C Boileau,2 V-K Nguyen,3 N Machouf,4 S Ag-Aboubacrine,5 PA Niamba,6 J Drabo,7 S Koala,8 C Tremblay9 andS Rashed10,111Unite´ de Sante´ Internationale, Cent