CYCLOSERINE Microbiology: Cycloserine inhibits cell-
wall synthesis in susceptible strains of
related to excessive blood levels (above
CAPSULES, USP
gram-positive and gram-negative bacteria
and in Mycobacteriumtuberculosis. DESCRIPTION
The ratio of toxic dose to effective dose
Cycloserine, (R)-4-amino-3-isoxazoli-
Susceptibility Tests: Cycloserine Streptomycesorchidaceus and has also
methods1 of determining the susceptibility
been synthesized. Cycloserine is a white
hematologic, renal excretion, blood level,
water and stable in alkaline solution. It is
rapidly destroyed at a neutral or acid pH. INDICATIONS AND USAGE PRECAUTIONS
Cycloserine is indicated in the treatment
General: Before treatment with
cycloserine is initiated, cultures should be
taken and the organism’s susceptibility
tuberculous infections, the organism’s
susceptibility to the other antituberculosis
Anticonvulsant drugs or sedatives may be
effective in controlling symptoms of CNS
toxicity, such as convulsions, anxiety, and
tremor. Patients receiving more than 500
mg of cycloserine daily should be closely
CYCLOSERINE
mg (2.45 mmol); D & C Yellow No. 10,
treatment of acute urinary tract infections
F D & C Blue No. 1, F D & C Red No. 3,
of pyridoxine in preventing CNS toxicity
F D & C Yellow No. 6, gelatin, iron oxide,
from cycloserine has not been proved.
talc, titanium dioxide, and other inactive
Escherichiacoli. It is generally no more
and is usually less effective than other
CLINICAL PHARMACOLOGY CYCLOSERINE
bacteria other than mycobacteria. Use of
cycloserine in these infections should be
during treatment, appropriate studies and
therapy has failed and when the organism
Laboratory Tests: Blood levels should
patients with reduced renal function, for
CONTRAINDICATIONS
cerebrospinal fluid, pleural fluid, fetal
to keep the blood level below 30 µg/mL.
• Depression, severe anxiety, or psychosis
Interactions: WARNINGS
Alcohol and cycloserine are incompatible,
the patient develops allergic dermatitis
to 6 hours after administration, with 50%
may result in increased incidence of CNS
effects, such as dizziness or drowsiness.
and patients should be monitored closely
Cardiovascular: Sudden development
charcoal instead of or in addition to gastric
Carcinogenesis, Mutagenicity, and
receiving 1 to 1.5 g of cycloserine daily
Impairment of Fertility: Studies Allergy (apparently not related to
employing gastric emptying or charcoal.
In adults, many of the neurotoxic effects
Skin rash
of rats showed no impairment of fertility
Miscellaneous:
prevented with the administration of 200
relative to controls for the first mating but
transaminase, especially in patients with
OVERDOSAGE Pregnancy Category C: A study in 2 Signs and Symptoms: Acute toxicity
generations of rats given doses up to 100
reserved for patients with life-threatening
effect in offspring. It is not known whether
toxicity from cycloserine is dose related
DOSAGE AND ADMINISTRATION
affect reproduction capacity. Cycloserine
currently administered only by this route.
The usual dosage is 500 mg to 1 g daily in
divided doses monitored by blood levels.2
Nursing Mothers: Because of the
The initial adult dosage most frequently
intervals for the first 2 weeks. A daily
dosage of 1 g should not be exceeded.
discontinue nursing or to discontinue the
drug, taking into account the importance
confusion, drowsiness, hyperirritability,
HOW SUPPLIED
paresthesias, dysarthria, and psychosis.
Usage in Pediatric Patients: Safety and
effectiveness in pediatric patients have
convulsions, and coma often occur. Ethyl
opaque gray body imprinted with “CHAO”
alcohol may increase the risk of seizures
and “F04” in edible black ink on both the
ADVERSE REACTIONS
Aluminum blisters (a pack of 3 cards each
with 10 capsules). NDC 13845-1202-2.
drug hypersensitivity. The following side
20° to 25°C (68° to 77°F) [see USP]. REFERENCES Nervous system symptoms (which
poison control centers are listed in the
of the drug, i.e., more than 500 mg daily)
Physician’s Desk Reference (PDR). In
Health Service, 1967, pp 47–55, 66–70.
of cycloserine, a new antibiotic. Anal
reported rarely. The following is provided
• Confusion and disorientation with loss
Protect the patient’s airway and support
limits, the patient’s vital signs, blood
gases, serum electrolytes, etc. Absorption
of drugs from the gastrointestinal tract
• Major & minor (localized) clonic seizures
effective than emesis or lavage; consider
Cornwall Sports Partnership Child Protection Policy Updated January 2008 Contents Page Number Responsibilities & codes of conduct for staff & coaches Responsibilities of the Volunteer / Helper Good Practice Guidelines for all staff, coaches, volunteers Children from minority, ethnic, racial, cultural or Action required in response to disclosure Roles &
Abilene Physicians Group Nicole Koske Bullock, D.O. Cervical ripening: Yes or No (circle one) Date/time of ripening: ________________________ Date/time of Induction: ________________________ Your induction of labor will be at Abilene Regional Medical Center. You should report to the nurse’s station on Labor and Delivery at the time above and tell the nurses you are scheduled for an indu
CYCLOSERINE
and patients should be monitored closely
Cardiovascular: Sudden development