CURRICULUM VITAE UNIVERSITY OF TOLEDO COLLEGE OF MEDICINE PERSONAL INFORMATION: Ragheb A. Assaly, M.D. Business Address: Home Address: EDUCATION AND TRAINING: M.D. Medicine & Surgery, University of Romania, Cluj-Napoca; 9/1977 - 9/1984 POST GRADUATE MEDICAL EDUCATION, FELLOWSHIP: 1984 -1985 Augusta Victoria Hospital, P.O. Box 19178, East Jerusalem, Rotating Internship 1985 -1987 Augusta Victoria Hospital, P.O. Box 19178, East Jerusalem, Internal Medicine
Makassed Hospital, P. O. Box 19482, Mount of Olives, East Jerusalem
Senior Resident and Chief Resident Internal Medicine, Completed requirement
for Jordanian Board in Internal Medicine
1990 -1991 Case Western University, 11100 Euclid, Cleveland, Ohio, United States,
Echocardiography training (three months).
1991 -1992 Makassed Hospital, P. O. Box 19482, Mount of Olives, Jerusalem, Educational
1992 -1993 D. C. General Hospital, 19th & Massachusetts Ave SE, Washington, D. C., United
1993 -1995 Grady Memorial Hospital, Morehouse School of Medicine, 720 Westview Dr. SW,
Atlanta, GA. United States, Resident in Internal Medicine
1995 -1998 Medical College of Ohio, 3000 Arlington Ave, Toledo, Ohio, United States,
Fellowship in Pulmonary/Critical Care Medicine.
1999 -2000 Medical College of Ohio, 3000 Arlington Ave, Toledo, Ohio, United States
2005 - 2006 University of Toledo, 3000 Arlington Ave, Toledo, Ohio, United States
Fellowship in Sleep Disorders, Sylvania Regional Sleep Center
2008 University of Toledo, 3000 Arlington Ave, Toledo, Ohio, United States Transformation Leadership Graduate Certificate 2009 - 2010 University of Toledo, 3000 Arlington Ave, Toledo, Ohio, United States Biostatistics and Clinical Research Graduate Certificate EMPLOYMENT: 1998 - 2004
Assistant Professor, Pulmonary/Critical Care Division, Medical University of Ohio, Toledo, OH
Associate Professor, Pulmonary/Critical Care Division, University of Toledo, Toledo, OH
Director, Medical Intensive Care Unit, University of Toledo, Toledo, OH
Associate Program Director, Internal Medicine Residency Program, University of Toledo College of Medicine
Program Director, Internal Medicine Residency Program, University of Toledo College of Medicine
2008 - Present Professor, University of Toledo College of Medicine 2011 -Present Chairman –Clinical Advisory Board for ADS Biotechnology. CERTIFICATIONS/LICENSURES: 1991 Medicine, National Board of Medical Examiners (ECFMG).
1995 Internal Medicine, American Board of Internal Medicine.
1995 Managed Care Program, Harvard Community Health Plan.
1996 Advanced Cardiac Life Support Provider, American Heart Association.
1996 Advanced Cardiac Life Support Instructor, American Heart Association.
1996 Advanced Trauma Life Support, American College of Surgeons.
1996 Clinical Hyperbaric Medicine, American College of Surgeons.
1996 Ohio State Medical License, State Medical Board of Ohio,
1997 Pulmonary Medicine, American Board of Internal Medicine.
1999 Teaching Scholars Fellowship. Medical University of Ohio 2000 Controlled Substances Registration Certificate (DEA) United States Department of Justice, Drug Enforcement Administration, Certification #: BA5558688 2003 Fellow of the American College of Chest physicians (FACCP) 2006 American Board of Internal Medicine Board Certified in Critical Care Medicine 2006-2016. 2006 American Board of Sleep Medicine - Board certified (no time limit) Diplomat, American Board of Sleep Medicine (DABSM) 2007 American Board of Internal Medicine. Internal Medicine 2007-2017. – Recertification. 2007 American Board of Internal Medicine Pulmonary Diseases 2007-2017. –recertification. 2008 Transformational Leadership Graduate Certificate, University of Toledo 2010 Biostatistics and Clinical Research Graduate Certificate University of Toledo MILITARY SERVICE: N/A PROFESSIONAL SOCIETIES: 1985 - Present
Member, American College of Physicians (ACP)
Associate, American College of Chest Physicians (ACCP)
Fellow, American College of Chest Physicians (FACCP)
Associate, American Thoracic Society (ATS)
American Society of Critical Care Medicine
National Arab American Medical Association
2004 – 2006 American Physiological Society 2006 – Present Member, American Academy of Sleep Medicine 2006- Present Member, the Alliance for Academic Internal Medicine (AAIM)
Member, Association of Program Directors in Internal
AWARDS AND COMMENDATIONS:
1982, 1983, and 1984. Academic Achievement Award, Medical School, Cluj-Napoca, 1995. Letter of Achievement. Representation of Georgia Team (winning First place) in Medical Jeopardy / Internal Medicine / Southern States
Competition; American College of Physicians (ACP), Atlanta, GA 1998 Best Case Report, American Thoracic Society / European Respiratory Society, Toronto, Canada, 1999- 2000 Faculty Teaching Award. Internal Medicine Department, Medical University of Ohio 1999 Alfred Soffer Research Award. American College of Chest Physicians, Chicago, IL, 2000 Extraordinary Abilities US Visa (O - Outstanding Visa) – Medical University of Ohio, 2002 National Medical Technology Award (NMTB), Principal Investigator- Loma Linda, CA, 2002 2002 American College of Chest Physician Leadership Program, San Diego, CA, 2004 - 2005. Faculty Teaching Award. Internal Medicine, Medical University of Ohio, 2006 - 2007. Faculty Teaching Award. Internal Medicine, University of Toledo Medical Center, 2007-2008 H. Donabedian Full-Time Faculty Teaching Award, Internal Medicine, University of Toledo College of Medicine, 2009- 2010 Dean’s Award for Teaching Excellence, University of Toledo College Of Medicine, PATENTS: 1.
US patent, file 02066: 7,037,895. An albumin-based colloid composition and method of use in treating hypovelmia and multi-organ dysfunction
US patent, file 04111: 10/985,798. Albumin-based colloid composition having at least One protected thiol region, and methods of use
US patent, file 05097: 11/258,646. An albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
US patent, file 01043: 60/279,017. The use of polyethylene glycol modified albumin (Pega) in shock and other capillary leak conditions
US patent application CIP, filed 10/25/2005, MUO-D2006-041. A method and a marker for quantifying multiple organ dysfunction (MODS) in systemic inflammatory response conditions.
European patent application, PCT/US06/41432. Polyethylene glycol modified albumin with cys-34 preserved as a thiol.
MENTORING: Name:
Analysis of methoxy-polyethylene glycol-modified albumin
Degree awarded to student: Masters Degree (to be defended December 14, 2005) Current position: PGY 3 Psychiatry resident at Johns Hopkins. Name:
Polyethylene glycol modified albumin (PEG-Alb) 5000 vs. (PEG-Alb)
Use of methoxy-polyethylene glycol-modified albumin in IL-2 induced
Capillary leak. Date 2011-2012 Current position:
Name: Abdullah Alajaji, MD Department:
Use of methoxy-polyethylene glycol-modified albumin in Hemorrhagic
Shock. Date 2011-2012 Current position:
JOURNAL PEER REVIEW: 2011-present Editorial Board of World Journal of Experimental Medicine (WJEM) . 2005-present Critical Care Medicine Journal of the Society of Critical Care Medicine (SCCM) 2005-present Chest Journal of the American College of Chest physicians (ACCP) STUDY SECTIONS, REVIEW PANELS: American Heart Association
Member, Peer Review Committee 1B - To review grant applications from the areas of Cardiovascular Development, Lung, Respiration and Resuscitation, Surgery, Radiology and Imaging, Orlando, Florida, April 2005. American Heart Association Member, Peer Review Committee 1B - To review grant applications from the areas of Cardiovascular Development, Lung, Respiration and Resuscitation, Surgery; Radiology and Imaging, Orlando, Florida, 2006. COMMUNITY SERVICE AND ORGANIZATIONS: 1996, 1997, 1998
Physicians for Peace, Medical Relief Mission
2010-2011 USAID Consultant in Critical Care and Education for Palestinian Health Sector Developed for the Palestinian Health Sector Reform and Development Project (Flagship Project) a manual prepared to target the Emergency Medicine, Anesthesia, Surgery, Family Practice, Internal Medicine residents as well as senior medical students and ICU nurses. Most of the policies developed were adapted to the context of local hospitals. Introduced evaluation system for residency training based on the six educational competencies Assisted in the development of the national residency program. COMMITTEES, University of Toledo College of Medicine: 2001 - 2005
Internal Medicine Residency Committee (Chairman)
(Advisory Committee to the Council of Deans and Board of Trustees) 2003 - 2004
Cultural Competence Curriculum Committee
2009- Pharmacy and Therapeutics committee. 2010- Simulation advisory committee 2011-
Clinical Advisory Committee for HEO (CPOE) for Implementation & Adoption
SPECIAL/INVITED PRESENTATIONS AT NATIONAL/INTERNAT’L MEETINGS: Assaly, RA Health consequences of smoking. Staging and modalities of treatment of lung cancer; Al Najah University, West Bank Palestine, Physicians for Peace International Conference, 7/1997 Assaly, RA Staging and modalities of treatment of lung cancer; Al Najah University, West Bank Palestine, Physicians for Peace International Conference, 7/1997 Assaly, RA Hypertensive Emergency; Hebron University, West Bank Palestine; Physicians for Peace International Conference, 7/1998 Assaly, RA Asthma Management; Hebron University, West Bank Palestine, Physicians for Peace International Conference, 7/1998 Assaly, RA Pulmonary Embolism/Diagnosis and Management; Beirzeit University, West Bank Palestine, Physicians for Peace International Conference, 7/1999 Assaly, RA Severe Sepsis Multi-organ Dysfunction; Beirzeit University, West Bank Palestine, Physicians for Peace International Conference, 7/1999 June 26 - July 5, 2003 University of Al-Quds, Jerusalem Medical School The following lectures were presented to Internal Medicine Residents and fourth year medical school students:
1. Management of Severe Asthma 2. Management of Sepsis 3. Mechanical Ventilation 4. ABG 5. Treatment of Shock 6. Hyponatremia 7. ARDS
Polyethylene glycol modified albumin in capillary leak conditions
American College of Chest Physicians (ACCP), Leadership Symposium, Orlando, Florida November 2003 Name of Activity: Respiratory Care Symposium, Medical College of Ohio, Toledo, OH, Dana
Pathophysiology of capillary leak in sepsis
Ohio Thoracic Society, Cambridge, Ohio July 1 - July 5, 2005 Al-Quds University / Makassed Hospital, Jerusalem, Israel Jerusalem Medical School The following lectures were presented to Internal Medicine Residents and Senior year medical school students:
1. Sepsis and multi-organ dysfunction syndrome 2. Pulmonary embolism 3. Shock-treatment 4. Morning report discussions
CONSULTATIVE ACTIVITIES: N/A MAJOR RESEARCH INTERESTS: Sepsis – New modalities of treatment Shock pathophysiology Endothelial cell function Colloids resuscitation PAST RESEARCH SUPPORT, TRAINING GRANTS: A Randomized Double-blind, Placebo-Controlled Study to Determine the Efficacy and Safety of Epoetin Alfa in Critically Ill Subjects; Johnson & Johnson Pharmaceutical Services, LLC/Johnson & Johnson 12/17/2003 – 12/16/2004 $91,770.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator Efficacy and Safety of Drotrecogin Alfa (activated) in Adult Patients with Early Stage Severe Sepsis; Lilly Research Laboratories/Eli Lilly and Company 8/20/2003 – 9/13/2004 $41,675.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator
A Comparison of the Efficacy, Safety and Pharmacokinetics of the Current US Version of Pulmicort Turbuhaler and the New Versus; AstraZeneca, L.P 1/1/2003 – 10/15/2004 $65,625.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A Phase 3 Comparative Efficacy Study of 5 Days of Clarithromycin Extended Release Tablets to 7 Days of Clarithromycin Immed; Abbott Laboratories 12/3/2002 – 6/3/2004 $15,990.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator An 18-week Randomized Double-blind, Placebo-controlled, Multi-center Study Designed to Compare Treatment with ARIFLO (Cil)’ GlaxoSmithKline 12/6/2002 – 8/20/2004 $84,000.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A Multi-Center Randomized, Double-blind, Double-Dummy, Parallel-group Comparison of Salmeterol Xinafoate Inhalation Aerosol; Glaxo SmithKline 11/6/2001 – 9/30/2002 $38,300.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator Protocol SPI-001: Evaluation of the Safety and Efficacy of Alph-hANP Infusion (Carpertide for Injection: Sun4936) in Patients with …; Suntory Pharmaceutical, Inc. 11/13/2001 – 8/14/2003 $50,000.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator The Use of Polyethylene Glycol Modified Albumin in Hypovolemia Department of the Army / Department of Defense 2/1/2002 – 7/31/2003 $132,074.00 Principal Investigator: Ragheb Assaly, Department of Medicine, Medical University of Ohio at Toledo Asthma Event Outcomes in Subjects Receiving Either Usual Pharmacotherapy of Asthma or Usual Pharmacotherapy plus Salmet; Glaxo Wellcome, Inc. 2/9/2001 – 10/17/2002 $525.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator
Asthma Event Outcomes in Subjects Receiving Either Usual Pharmacotherapy of Asthma or Usual Pharmacotherapy plus Salmet; Glaxo Wellcome, Inc. 2/9/2001 – 10/17/2002 $1,875.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator An Open-Label Pilot Study of the Safety and Efficacy of Tobramycin Solution for Inhalation (TOBI) for Patients with Severe Bronc; PathoGenesis Corporation 7/1/2000 – 6/26/2002 $13,050.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator CURRENT RESEARCH SUPPORT, TRAINING GRANTS: A Randomized Double-blind, Placebo-controlled, Phase-2b Study to Assess the Safety and Efficacy Effects of ART-123 on Subjects with Sepsis and Disseminated Intravascular Coagulation; Artisan Pharma, Inc. 2/2009- 2/2012 $140,000.00 Ragheb Assaly, M.D, Principal Investigator, University of Toledo College of Medicine A Phase 4, Randomized, Double blind, Multi-center, Comparator Study Evaluating the Safety of Dexmedetomidline Compared to…; Hospira, Inc. 3/16/2005 – 3/15/2006 $20,840.00 Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A 12-month Double-blind Randomized, Parallel Group, Multicenter Efficacy and Safety Study of Symbicort; AstraZeneca, L.P. 3/14/2005 – 3/13/2006 $60,000.00 Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A Randomized, Double-blind, parallel Group, 52-week Study to Compare the Effect of Cluticasone Propionate/Salmeterol DISKUS; GlaxoSmithKline 10/25/2004 – 3/28/2007 $72,474.00 Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A Multi-center, Randomized, Open-label Phase 3 Study to Compare the Safety and Efficacy on Intravenous Doripenem with that…; Peninsula Pharmaceuticals, Inc. 12/1/2004 – 11/30/2006 $56,000.00 Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo
Ragheb Assaly, M.D. – Co-Investigator Linezolid in the Treatment of subjects with Nosocomial Pneumonia Proven to be due to Methicillin-Resistant Staphylococcus aurous; Pfizer, Inc. 12/21/2004 – 12/20/2005 $64,000.00 Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A Phase 3, Multi-Center, Randomized, Placebo-controlled, Double-blind, Three-Arm Study to Evaluate the Safety and Efficacy of…; Chiron Corporation 6/30/2004 – 6/29/2006 $68,800.00 Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A Clinical Study of ONO-6126 Ono Pharma USA, Inc. 3/10/2004 – 7/31/2006 $24,000.00 Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator Van Gogh - DVT Trial Sanofi-Synthelabo Research 9/6/2003 – 6/16/2006 $8,000.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A Multicenter, International Randomized, Open-label, Assessor-blind, Non-inferiority Study of the Efficacy & Safety of Subcutaneous…; Sanofi-Synthelabo Research 12/8/2003 – 6/17/2006 $48,000.00 Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A Multi-center, Randomized, Double-blind, Double-dummy, Parallel Group, 42-week Comparison of Asthma Control in Hyperresp…; GlaxoSmithKline 2/3/2003 – 1/14/2006 $68,000.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator A Double-blind Placebo-controlled, Study of E5564, a Lipid an Antagonist, Administered by Twice Daily Intravenous Infusions in…; Eisai Medical Research Inc. 9/10/2005 – 6/16/2006 $69,424.00
Jeffrey Hammersley, M.D. Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator Effects of Salmeterol/Fluticasone Propionate (Seretide/Viani/Advair) 50/500 ug bd, Salmeterol 50 ug bd and Fluticasone Propionate; Glaxo Wellcome Inc. 7/1/2001 – 1/31/2006 $60,000.00 Dan Olson, M.D., Ph.D., Department of Medicine, Medical University of Ohio at Toledo Ragheb Assaly, M.D. – Co-Investigator TEACHING ACTIVITIES: Name of Activity: Core Curriculum, Medical College of Ohio, Toledo, OH Presenter:
Third and fourth year medical students and Internal Medicine Residents on Med III. Medical Intensive Care Unit rotations and Residents from Surgery and Anesthesiology rotating with us will attend as well.
Attendees per session: 15 - 20 How many per year: Up to15 sessions per year (during my 3 year fellowship training)
1. Pearls from the American College of Chest Physicians, November 1996. 2. Minimally Invasive Coronary Artery Bypass Surgery (MIDCAB), New Approach to
3. Adjunctive Drug Therapy of Acute Myocardial Infarction, March 1997. 4. American Thoracic Review May 1997. 5. SIRS and Sepsis, New Concepts (Cars, Mods), 1997 6. Standards for the Diagnosis and Care for Patients with Chronic Obstructive Pulmonary
7. Primary Pulmonary Hypertension, “American College of Chest Physicians” Consensus,
Pulmonary Core Curriculum, January 1997.
8. Bronchiolitis Obliterans Organizing Pneumonia, January 1997. 9. Eosinophilic Lung Disease – Review, February 21, 1997. 10. Carcinoid Syndrome (Review), Endobronchial Carcinoid – Case Presentation, February
11. Drug Related Pulmonary Toxicity – Discuss Clinical Presentation; Pathology, Outcome
Treatment – Drug Induces Lupus, 1-Criteria for Diagnosis, 2- Drugs Recently Associated with Lupus.
12. An Integrated Approach to Interpretation of Cardiopulmonary Exercise Testing – Basic
Concepts Part I, April 1997, Pulmonary Core Curriculum, Medical College of Ohio, Toledo, OH, April 1997.
13. Pulmonary Fungal Infections, May 1997. 14. Pleural Effusion – Overview: Case Presentation – Mesothelioma, May 1997 15. Common Presentations of Uncommon Diseases May 1997. 16. CT scans Chest Presentations, December 1997.
17. ICU Protocols – Cost Effectiveness, December 1998. 18. Acute Eosinophilic Pneumonia Triggered by 2-4-D. A Case Report, January 1998. 19. Clinical – Pathology Presentation, February 1998. 20. X-Ray Presentations, February 1998. 21. Hemodynamic Monitoring in the ICU, July 1998. 22. Meningoencephalitis in the ICU, August 1998. 23. Invasive Procedures in a Critical Care Setting, August 1998.
Name of Activity: Respiratory Care Symposium, Medical College of Ohio, Toledo, OH Presenter: RA Assaly Attended by: Physicians, respiratory therapists, residents, people interceded in the community Attendees per session: Once every year or every other year How many per year: 200 - 300
1. Health Consequences of Smoking, November 1998 2. Assaly RA. Pulmonary Hypertension, November 2000
Name of Activity: Board Review in Critical Care. Medical College of Ohio, Toledo, OH Presenter: RA Assaly Attended by: Third year medical residents as preparation for the Internal Boards Attendees per session: 40 - 50 How many per year: Once a year. Name of Activity:
Lecture for Physicians Assistant Program, Medical College of Ohio, Toledo, OH, School of Allied Health
Presenter: RA Assaly Attended by: Second year Physicians Assistants Attendees per session: Once every year How many per year: 30 - 40
1. Sepsis – New Concepts, Physician Assistant Program, January 2, 1997 2. Sepsis - Basic Concepts, February 1998 3. Sepsis - Basic Concepts, January 1999 4. Sepsis - Basic Concepts, January 2000 5. Sepsis - Basic Concepts, January 2001 6. Sepsis - Basic Concepts, January 2003 7. Sepsis - Basic Concepts, January 2004 8. Sepsis - Basic Concepts, January 2005
Name of Activity: Acid Base Disturbances, Medical College of Ohio, Toledo, OH Presenter: RA Assaly Attended by: Second year medical students Attendees per session: 10 -15 How many per year: Once/year Name of Activity: Grand Rounds, Medical College of Ohio, Toledo, OH Presenter: RA Assaly Attended by: Medical students, residents and faculty Attendees per session: 70 - 75 How many per year: Once/year
1. Capillary Leak Syndrome, 1999 2. Sepsis and Multi-Organ Dysfunction, 2000 3. New Treatment Modalities in Sepsis, 2002 4. Update on Sepsis Management, 2003 5. Acute Respiratory Distress Syndrome, 2005
Name of Activity: Tuesday Subspecialty Conference, Medical College of Ohio, Toledo, OH Presenter: RA Assaly Attended by: Medical students, residents and faculty. Attendees per session: 30 - 40 How many per year: Two lectures/year
1. Hypertension in the Hospital Setting, April 13 1999 2. Developing a Curriculum for Residents and Medical Students In Critical Care,
3. Mechanical Ventilation, March 2001 4. Asthma: State of the Union, December 12, 2001 5. Critical Care Review, July 9, 2002 6. Acute Respiratory Distress Syndrome: Pathophysiology and Management, March 12,
7. Hypertensive emergency, 2003 8. Teaching In Critical Care Setting, 2004
Name of Activity: Teaching Scholars Graduation Presenter: RA Assaly. Attended by: MCO President, Dean and faculty Attendees per session: 30 – 40 How many per year: This was a one time event. “Teaching in Critical Care Setting.” Project presented at the graduation of the teaching
scholars fellowship, Medical College of Ohio, Toledo, OH. Poster session at the Faculty Lounge in the campus Hilton Hotel, Toledo, OH, September 1999
Course Director Physical exam training for internal medicine residents and medical students Teaching sessions divided in 5 modules to cover all the systems. Once a week for 10 weeks/year Co-Course Director Board Review Internal Medicine Community physicians and third year internal medicine residents June 2005, May 2006 and May 2007 Director - Fellow Conference Symposium Quarterly First conference 11/2005 Multispecialty conference, clinical and pathological correlation Subspecialty fellows, local and community physicians Board Review Sessions
Weekly 8/2007 Residents (first, second, and third years)
BIBLIOGRAPHY Scientific Publications (peer reviewed): Anis Toumeh MD, Navpreet Josh MD, Rawan Narwal MD, Ragheb Assaly MD Refractory Thrombotic Thrombocytopenic Purpura associated with Primary Sjogren's syndrome Treated with Rituximab; a case report" American journal of Therapeutics. In Press Accepted Oct 25, 2011 Assaly, R. Right Axis Deviation I n Systemic Capillary Leak syndrome. Ann Intern Med. 2010 6; author reply. Torok N. MD , Niazi M. MD , Al Ahwel y. MD, Taleb M. MD, Taji J.MD, Assaly R. MD Thrombotic thrombocytopenic purpura associated with anti-glomerular basement membrane disease. Accepted June 2010 in Nephrology, Dialysis, and Transplantation Journal. Torok N. MD, Donaldson B. MS, Taji j. MD, Abugiazya A. MD, Assaly R. MD. Diffuse alveolar damage and recurrent respiratory failure secondary to Sertaline. Accepted June 2010 in American journal of Therapeutics. Maisa Nazzal, Fadi Safi, Ragheb Assaly. Micafungin induced Thrombotic Thrombocytopenic Purpura case report and review of the literature. American Journal of Therapeutics: 19 March 2010 doi: 10.1097/MJT. Asma Taj, Shaffi Kanjwal .Ragheb A. Assaly, Jeffrey R.Hammersley. Pulmonary Capillaritis in a classical polyarteritis nodosa. Int J of Pulmonary medicine, 2009 Volume 11 Number 2. Assaly RA, Habib RH, Azizi M, Shapiro JI, Dignam JD. Use of multiple fluorophores for evaluating microvascular permeability in control and septic rats. Clinical Science 2008; 114, 123–130. Intensive intra-operative insulin therapy versus conventional glucose management during cardiac surgery. Ann Intern Med. 2007 Oct 2; 147(7): 521 author reply 522.
. Dynamic respiratory mechanics measurements for optimization of ventilator settings in acute lung injury. Crit Care Med 2007 July; 35(7):1806-7; author reply 1807-8. Avram R, Kleshinski J, Elsamaloty H, Williams J, Assaly, RA. Coronary artery bypasses graft pseudoaneurysm: Report of three cases. Eur J Radiol, published online June 18, 2008. Clearance of linezolid
via continuous venovenous hemodiafiltration. Am J Kidney Dis. 2006 Jun; 47(6):e83-6. Al-Astal, A., Olson DE, Hammersley JR, Assaly RA, Yoon Y, Willey JC. Acute Eosinophilic pneumonia in a 19 y/o male. J Resp Dis 2005, Vol. 26 (8) 361-362. Assaly RA, Azizi M, Kennedy DJ, Amauro C, Zaher A, Houts FW, Habib RH, Shapiro JI, Dignam JD. Plasma expansion by polyethylene glycol modified albumin. Clinical Science 2004; 107(3): 263-272. Harr M, Roshong-Denk S, Graves T, Elsamaloty H, Coombs R, Durham S, Al-Astal A, Knight C, Hernandez D, Olson DE, Crawford E, Amurao G, Sharief I, Hammersley J, Assaly R, Yoon Y, Zaher A: The c-myc xE2f-1/p21 interactive gene expression index augments cytomorphologic. Diagnosis of lung cancer in fine needle aspirates specimens. J Mol Diag 2003 5(3): 176-183. Assaly RA, Hammersley JR, Olson DE, Farrouk A, Zaher A, Amurao GV, Shelley WB, Shelley ED, Amurao CV. Disseminated Blastomycosis: J Am Acad Dermatol, Jan 2003; 48(1): 123-7. Assaly RA, Hammersley JR, Olson DE, Shapiro J, Kahaleh MB. Initial evidence of endothelial
cell apoptosis as a mechanism of systemic capillary leak syndrome. Chest 2001; 20(4):1301-1308.
Amurao GV, Gottwald L, Duggan J, Amurao CV, Assaly RA. Vaccine-era measles in an adult. Cutis 2000; 66(5): 337-340. Non-Peer Reviewed publications: Assaly RA. Manual “Introductory Course in General Clinical Practice at Primary Health Care Level”, Jerusalem Medical Council, 1992. Abstracts September 1998 Ohio Thoracic Society Meeting, Columbus, Ohio
1. Assaly RA. Mystery dyspnea in a patient with immunotactoid glomerulopathy. 2. Assaly RA. Alveolar hemorrhage syndrome with positive lupus serology one month
3. Assaly RA. Yellow nail syndrome – Prediction of occult malignancy. 4. Assaly RA, Olson DE, Hammersley JR, Hamilton R. Dyspnea in a patient with
October 1998 American College of Physicians, Columbus, Ohio
1. Assaly RA. Blastomycosis misdiagnosed as Cryptococcoses. 2. Assaly RA. Valproic acid causing metabolic acidosis; Case Report. 3. Amurao G, Assaly RA. Measles in adults. 4. Kleshinski J, Assaly RA, Olson D. Herpes simplex encephalitis in the elderly. 5. Assaly RA. Alveolar hemorrhage – Capillaritis in a classical polyarteritis nodosa.
6. Assaly RA. Yellow nail syndrome. 7. Assaly RA. Interstitial lung disease in a patient with fibrillary glomerulonephritis. 8. Singh, A, Assaly RA. Pancreatic encephalopathy, American College of Physicians. 9. Assaly RA, Hammersley JR, Olson DE. Blastomycosis in a Saudi Arabian young
10. Ali-Hasan S, Olson DE, Assaly RA. Troponin I as an indicator of sepsis. 11. Amurao G, Duggan J, Assaly RA. Measles in adults. 12. Kleshinski J, Assaly RA, Olson DE. Herpes simplex encephalitis in elderly. 13. Assaly RA, Olson DE, Hammersley JR, McFarland R. Should valproic acid be
discontinued in patients with seizures who develop high anion gap acidosis?
November 1998 Critical Care Symposium, Toronto, Canada, 1998 1. Assaly RA, Hammersley JR, Olson DE. Systemic capillary leak syndrome: Case Report
2. Assaly RA, Khalil H, Hammersley JR, Olson DE. A very rare entity with successful
response to antileukotriene systemic capillary leak syndrome - Responsive to antileukotriene case report and review of literature.
3. Assaly RA, Ali-Hasen S, Olson DE, Hammersley JR. Troponin I as a marker for sepsis. 4. Assaly RA, Olson DE, Hammersley JR, McFarland R. Should valproic acid be
discontinued in patients with seizures who develop high anion gap acidosis?
5. Assaly RA, Hammersley JR, Olson DE. Acute eosinophilic pneumonia presenting as
October 1999 American College of Physicians, Columbus, Ohio
1. Assaly RA, Acharya J. Systemic lupus associated with Hashimoto’s and pernicious
anemia with positive antiparietal cell antibodies.
2. Assaly RA, Lober J, Hammersley J. Systemic capillary leak syndrome. 3. Assaly RA, Kyobe M, Olson D. Adrenal insufficiency as a cause of fever of unknown
4. Assaly RA, Ravindiran A, Sharma S. CA 125 elevation in atrial myxoma. 5. Assaly RA. Hertroff S. Hydrocephalus in neurosarcoidosis. 6. Assaly RA, Solaiman D. Ceftriaxone causing pseudolithiasis.
November 1999 American College of Chest Physicians. Abstracts, published in CHEST, Chicago, Illinois.
1. Assaly RA, Hammersley JR, Olson DE, Shapiro J, Kahaleh M. Apoptosis of
endothelial cell as a cause of capillary leak syndrome.
2. Assaly RA, Hammersley JR. Acute eosinophilic pneumonia presenting as ARDS.
October 28-30, 2000 Toronto Critical Care Symposium / Abstract, Toronto, Canada
1. Assaly R, Amurao G, Hammersley J, Olson DE. “Subcutaneous use of fenoldopam”.
September 2001 Ohio Thoracic Society / Abstract, Cambridge, Ohio
1. Amurao GV, Olson DE, Hammersley J, Willey J, Yoon Y, Assaly RA. Subcutaneous
use of fenoldopam in pulmonary hypertension.
2. Sharief I, Olson DE, Hammersley J, Amurao GV, Amurao CV Assaly RA. Fibrillary
May 2002 American Thoracic Society. Published in Am J Respir Criti Care Med (AJRCCM), Atlanta, Georgia
1. Willey JC, Crawford EL, Zaher A, Hammersley JR, Olson DE, Yoon Y, Assaly RA,
Zahorchak R. Expression analysis of HNF3A, mucini, ICAM1, SPR1, involucrin keratin 5, neuron specific enolase, and other differentiation specific genes in normal and squamous metaplastic bronchial epithelial samples.
2. Assaly RA, Amurao C, Shapiro JI, Habib RH, Dignam JD. Superior hemodynamic
resuscitation using a polyethylene glycol modified albumin (PEG-Alb) fluid in rats with endotoxin-induced shock”.
3. Amurao GV, Amurao CV, Assaly RA, Khuder SA, Hammersley JR, Olson DE, Sharief I,
Willey JC, Yoon Y. Comparison of “Closed” and “Open” Intensive Care Unit (ICU) Organizational Models: A Meta-Analysis.
4. Amurao C, Assaly RA, Shapiro JI, Habib RH, Hammersley JR, Olson DE, Dignam JD.
Reduced capillary leak and lung injury using a polyethylene glycol modified albumin (PEG-Alb) resuscitation fluid in rats with endotoxin-induced shock.
November 2002 American College of Chest Physicians / Abstracts published in CHEST, San Diego, CA
1. Sharief I, Yoon Y, Olson DE, Assaly RA, Hammersley JR. Pericardial tamponade as
the first manifestation of small cell lung cancer.
2. Sharief I, Yoon Y, Olson DE, Hammersley JR, Amurao GV, Willey JC, Assaly RA.
Disseminated mucomycosis in a patient with renal transplant. A Case Report and Review of the Literature.
3. Sharief I, Ellis S, Olson DE, Hammersley JR, Shahin A, Willey JC, Yoon Y, Assaly RA.
Pulmonary hypertension secondary to tumor-related pulmonary microangiopathy simulating primary pulmonary hypertension.
May 2003 American Thoracic Society / published American Journal of Respiratory and Critical Care Medicine (AJRCCM), Seattle, Washington Assaly RA, Dignam D, Habib R, Shapiro J. Superior and more rapid reversal of hypovolemic hypotension using polyethylene glycol modified albumin. October 2003 American College of Chest Physicians. Published in CHEST, Orlando, Florida Astal A, Olson DE, Hammersley JR, Assaly RA. Allergic bronchopulmonary mycosis secondary to Scedosporium Apiospermum in a patient with partial immotile cilia syndrome.
April 14-16, 2005 American College of Physicians (ACP), San Francisco, CA Chahal M, Assaly RA. Constrictive pericarditis in a patient with rheumatoid arthritis treated with infliximab. Case presentation accepted for poster session, Clinical Vignette Competition. October 2005 American College of Physicians, Ohio Chapter, Columbus, Ohio Mikkelini H, Assaly RA. Accelerated IPF, idiopathic pulmonary fibrosis. May 2006 American Thoracic Society Meeting. Abstracts / AJRCCM, San Diego, CA Assaly RA, Habib RH, Azizi M, Hernandez D-A, Nadour J, Shapiro JI, Dignam JD. Polyethylene glycol modified albumin (PEG-Alb) volume expansion in hemorrhagic shock (HS). Assaly RA, Habib RH, Ruiz J, Al-Baghdadi M, Azizi M, Shapiro JI, Dignam JD. Timing and quantifying systemic capillary leak via a novel dual fluorescence technique. October 2006 American College of Chest Physicians, 72nd Annual International Assembly, Salt Lake City, UT Al-Baghdadi MW, Assaly R, Ghai V. Cerebral venous sinus thrombosis in a patient with diabetic ketoacidosis and predisposition to thrombosis. Chest 130(4) Oct. 2006 supplement. Assaly RA, Habib R, Shapiro JI, Azizi M, Dignam D. A novel, double fluorescence technique for quantifying intravascular retention of polyethylene glycol albumin 40.000 (PEG-Alb 40.000). Chest 130(4) October 2006 supplement. May 2007 American Thoracic Society International Meeting, San Francisco, CA Assaly RA, Habib R, Azizi M, Al-Baghdadi M, Ruiz J, Shapiro JI, Dignam JD. Polyethylene glycol modified albumin at a single site (PEG-Alb 40,000) is at least equivalent to multiply modified albumin (5000) in maintaining hemodynamics in a cecal ligation and puncture (CLP) model of sepsis. Am J Respir Crit Care Med, April 2007, page A237. August 1-5, 2007 American Task Force on Palestine Makassed Teaching Hospital – Jerusalem, Israel Lecture series for the residents October 2007 American College of Chest Physicians – Chicago, IL Assaly RA, Habib R, Azizi M, Al-Baghdadi M, Ruiz J, Shapiro JI, Dignam JD. Comparisons of multiple sizes of PEG-albumins in restoring hemodynamics in septic shock in the rat. February 2 - 8, 2008 1st International Conference on Drug Design and Discovery, Dubai, UAE Assaly RA, Habib RH, Azizi M, Shapiro JI, Dignam JD. Plasma expansion by polyethylene glycol modified albumin (PEG-Alb). April 2009 American Thoracic Society International Meeting, San Diego, CA. Published in Am J Respir Crit Care Med Assaly RA, Habib RH, Azizi M, Shapiro JI, Dignam JD. Polyethylene glycol resuscitation in hemorrhagic shock in rats. October, 2009 American College of Chest Physicians. October, 2009 San Diego. Boughazia, A, Torok, N, Assaly R Lab Acquired Cocciidomycosis May, 2010 American Thoracic Society International Meeting, New Orleans. Published in Am J Respir Crit Care Med Rajan Goyal, Niazi M, Torok, N, Assaly R
Abs. ID/Title: #4201 - Carcinoid with Tumorlet syndrome Session: D43 - Interesting Cases of Tumors and More Session Type: Thematic Poster Session- Poster Presentation Date: Wednesday, May 19, 2010 Time: 8:15 AM-4:00 PM
Rajan Goyal, Niazi M, Torok, N, Assaly R
Abs. ID/Title: #7173 - Coexistent TTP and Goodpasture syndrome Session: D51 - Strange Rangers in the ICU: Selected Case Reports Session Type: Thematic Poster Session- Poster Presentation Date: Wednesday, May 19, 2010 Time: 8:15 AM-4:00 PM
Jamil Taji, Torok N, Assaly R
Comparing Epionce ® & Prescription Renova ® ABSTRACT In a controlled clinical study, an Epionce regimen produced similar results in improving the appearance of photoaging parameters com- Parameter Epionce (% Change) Renova (% Change) pared to the gold standard Renova (prescription 0.05% tretinoin). Using a split-face methodology, an Epionce regimen was compared with prescriptio
REKLISTAN 2010 75 rEKommENdErAd FySISK AKtIvItEt vId ArtroS, LåNGvArIG SmÄrtA uNS och FIbromyALGI ArtroS Träningen bör inledningsvis ske som anpassad träning under ledning av sjukgymnast. Styrketräning kompletterad med rörlighet, balans och koordinationsfrämjande träning bör vara individuellt avpassad och ske 3 gånger/v. Konditionsfrämjande träning av mått-lig intensi
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