Microsoft word - cve20100904masa.doc

Department of Endocrinology and Diabetes TEL:+81-49-228-3400 (operator), 3564 (office) FAX:+81-49-225-6649 (office), +81-49-228-3798 (room) e-mail: [email protected] [email protected] TEL:+81-4-7092-2315 Education and Academic Degree Attached High-School of University of Hiroshima Science 3, College of Art and Science, The University of Tokyo Faculty of Medicine, The University of Tokyo Bachelor of Medicine (M.D.) (March 27, 1982) Doctor of Medical Science (Ph.D.) (July 12, 1989) Resident: University of Tokyo Hospital (Hongo, Tokyo, Japan, 6/10/82 – 1/9/83) Resident: University of Tokyo Hospital Branch (Meziro, Tokyo, Japan, 1/10/83 – Resident: Yamaguchi University Hospital (Ube, Yamaguchi, Japan, 4/1/83 – Resident: Shuto General Hospital (Yanai, Yamaguchi, Japan, 9/1/83 – 5/31/84) Staff: Yamaguchi University Hospital (Ube, Yamaguchi, Japan, 6/1/84 – 5/31/87) Assistant: Internal Medicine, Yamaguchi University (Ube, Yamaguchi, Japan, Physician: Saiki Hospital (Nagato, Yamaguchi, Japan, 6/1/88 – 3/31/89) Staff: Yamaguchi University Hospital (Ube, Yamaguchi, Japan, 4/1/89 – 5/31/90) Visiting Scientist: Diabetes Division, University of Texas Health Science Center at San Antonio (UTHSCSA) (San Antonio, Texas, USA, 6/1/90 – 2/28/93) Clinical Instructor: Diabetes Division, UTHSCSA (San Antonio, Texas, USA, 3/1/93 Instructor: Diabetes Division, UTHSCSA (San Antonio, Texas, USA, 9/1/94 – Assistant Professor of Medicine: Diabetes Division, UTHSCSA (San Antonio, Texas, Co-Director, Clinical Research Center, Texas Diabetes Institute (1996 – 1997) Medical Research Director, Clinical Research Center, Texas Diabetes Institute Lecturer, Diabetes Division, Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan (1/1/99 – 3/31/00) Lecturer, Endocrine and Diabetes Division, Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan (4/1/00 – 12/31/05) Lecturer (part time), Kawasaki College of Allied Health Professions, Kurashiki, Director, Diabetes and Endocrine Department, Kameda Medical Cener (1/1/06- Professor, Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University (4/1/09-present) Lecturer (part time), and Metabolic Diseases, University of Tokyo (4/1/10-present) Boards / License Medical Examination of National Board (Japan) May 25, 1982, No.265768 Standard ECFMG Certificate (USA) 1991 No. 0-344-588-9 Board Certificate in Internal Medicine (Japan) December 20, 1991, No.69753 Board Certificate in Hematology (Japan) April 1, 1991, No.1359 (currently inactive) Board Certificate in Diabetology (Japan) November 29, 1993, No.1505 Board Certificate in Endocrinology and Metabolism (Japan) April 1, 1994, Texas State Teaching Fellow Permit No. TF-93-19 (June 3, 1993 - June 3, 1994) Texas State Faculty Temporary License No. 31226 (December 1, 1996 - 1999) USMLE Step 1 and Step 2 passed (1997) USMLE Step 3 passed (1998) Certified Physician for Residency Training of Diabetology (Japan) December 5, Assigned Physician for Residency Training of Internal Medicine (Japan) 2001 Certified Physician for Residency Training of Endocrinology (Japan) April 1, 2004, Nutrition Support Team Coordinator (Japan) Apirl 1, 2005, No. 04-168 Fellow of the Japanese Society of Internal Medicine, December 12 2005, No.9135 Professional Honors / Grants 1991 - 1993 Juvenile Diabetes Foundation Research Fellowship 1993 - 1994 American Diabetes Association Mentor Based Postdoctoral Fellowship 1994 - 1996 Fujisawa Corp. Research Grant "Identification of Specific Proteins in American Diabetes Association Travel Grant 2001-2002 Grant-in-Aid for Scientific Research (C)(2) Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science, and Technology , Japan “Pathophysiological Analysis of Leptin Resistance in Type 2 Diabetes Mellitus” Member, Japanese Society of Clinical Hematology Member, Japan Association of Medical Informatics Member, Japanese Society of Internal Medicine Life Member, International Diabetes Federation Member, European Association for the Study of Diabetes Member, Japanese Society of Clinical Nutrition Regional Councilor of Japanese Society of Internal Medicine (2000-present) Delegate member to a council of Japan Endocrine Society (June 14, 2000-present) Councilor of Japan Society of Clinical Nutrition (2001-present) Councilor of Japan Diabetes Society (May, 2003-present) Editorial Board Member of Journal of Japan Diabetes Society (May, 2005 – Dec, Journal Referee 1994 - 1996 Reviewer of American Journal of Physiology Reviewer of Diabetes Research and Clinical Practice Reviewer of International Journal of Experimental Diabetes Research Journal of Diabetes and Its Complications Nutrition, Metabolism & Cardiovascular Diseases Nutrition, Metabolism & Cardiovascular Diseases Permanent Resident of the USA (from 1996 – 2004) 1. Matsuda M: Why Biguanides were not used for a certain period of time. E. R. Kawamori, Fuji Medical, Osaka, Japan pp 29-36, 2005. [Japanese] 2. Matsuda M, Kaku K: Therapeutic Guide Line of Diabetes Mellitus Ed. K. Shirota and K. Node, Medical View, Tokyo, Japan pp 240-245, 2004. [Japanese] 3. Matsuda M: Self Monitor of Blood Glucose. In Kaku K (Ed) Insulin Q&A Japan Medical Publisher, Tokyo, Japan pp.67-74, 2004. [Japanese] 4. Matsuda M: Recent advances in the pathophysiology and diagnosis in Diabetology. In Yazaki Y (Ed) Progress in Molecular Diabetology – from basic to clinical science - Kanehara Shuppan, Tokyo, Japan, pp.102～108, 2002. [Japanese] 5. Matsuda M, Kaku K: Lactic Acidosis. In Hinohara S, Imura Y (Eds) Diabetes and Its Complications, Recent Lecutures for Nurses, Nakayama Shoten, Tokyo, Japan pp.312～318, 2001. [Japanese] 6. Matsuda M: Comparison of Repaglinide and glibenclamide for one year. In Iwamoto Y (Ed) DATA UPDATE in Diabetes mellitus, Sentan Igakusha, Tokyo pp.146～147, 2001. [Japanese] 7. Matsuda M: Combination therapy of metformin and repaglinide. In Iwamoto Y (Ed) DATA UPDATE in Diabetes mellitus, Sentan Igakusha, Tokyo pp.144～145, 2001. [Japanese] 8. Saito M, Eto M, Okada M, Kawasaki F, Takeuchi Y, Matsuda M, Kaku K: Role of remnant-like particles (RLPs) from diabetic patients on cholesteryl ester synthesis. In Shichiri M, Chinn SH, Hotta N (Eds) Diabetes mellitus: Recent Advances fro the 21st Century, Elsevier (Amsterdam, Netherlands) pp.201～204, 2000 9. Masafumi Matsuda, and Kohei Kaku: Oral Hypoglycemic Agents pp. 136-141, In Annual Review Endocrine and Metabolism 2000. [Chugai Isho], Tokyo Japan. 10. Masafumi Matsuda, and DeFronzo, R.A.: In vivo Measurement of Insulin Sensitivity in Human. pp. 23-65, In Draznin,B and Rizza,R (eds) Clinical Research in Diabetes and Obesity, Part I: Methods, Assessment, and Metabolic Regulation 1997 Humana Press, Totowa, NJ, USA. 11. Kohei Kaku, Matsuda,M., Kaneko,T. and Permutt,M.A.: Genetic analysis of diabetic susceptibility in inbred mouse strains. Recent advances in insulin therapy. Tai Hee Lee et al.(Ed) Springer International pp.127-130, 1990. 2. Papers 1. DeFronzo RA, Matsuda M: Reduced time points to calculate the composite index 2. Jani R, Molina M, Matsuda M, Balas B, Chavez A, DeFronzo RA, Abdul-Ghani M.: Decreased non-insulin-dependent glucose clearance contributes to the rise in fasting plasma glucose in the nondiabetic range. Diabetes Care 31:311-5, 2008. 3. Abdul-Ghani M, Matsuda M, Jani R, Jenkinson CP, Richardson DK, Kaku K, Defronzo RA.: The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance Am J Physiol Endocrinol Metab. 295:E401-6, 2008. 4. Kanda Y, Matsuda M, Tawaramoto K, Kawasaki F, Hashiramoto M, Matsuki M, Kaku K.: Effects of sulfonylurea drugs on adiponectin production from 3T3-L1 adipocytes: implication of different mechanism from pioglitazone. Diabetes Res Clin Pract. 81:13-8, 2008. 5. Makoto Shigeto, Masashi Katsura, Masafumi Matsuda, Ohkuma Seitaro, Kohei Kaku: Low, but physiological, concentration of GLP-1 stimulates insulin secretion independent of the cAMP-dependent protein kinase pathway. Journal of Pharmacological Sciences. 108(3):274-9, 2008. Epub 2008 Nov 6. 6. Abdul-Ghani MA, Matsuda M, DeFronzo RA.: Strong association between insulin resistance in liver and skeletal muscle in non-diabetic subjects. Diabet 7. Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, Mari A, Defronzo RA.: Thiazolidinediones Improve Beta-Cell Function in Type 2 Diabetic Patients. Am J Physiol Endocrinol Metab. 292:E871-83, 2007. 8. Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA.: Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care 30:89-94, 2007. 9. Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K.: Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum. J Pharmacol Exp Ther. 322:1-7, 2007. 10. Matsuki M, Matsuda M, Kohara K, Shimoda M, Kanda Y, Tawaramoto K, Shigetoh M, Kawasaki F, Kotani K, Kaku K.: Pharmacokinetics and pharmacodynamics of glimepiride in type 2 diabetic patients: compared effects of once- versus twice-daily dosing. Endocr J. 54:571-6, 2007. 11. Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K.: First phase of glucose- stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx. J Pharmacol Sci. 101:293-302, 2006. 12. Saito M, Kuratsune H, Nitta H, Kawahara K, Hamano M, Matsuda M, Kaku K, Eto M.:Plasma lipid levels and nutritional intake in childhood- and adolescence- onset young type 1 diabetic patients in Japan. abetes Res Clin Pract. 2006 Jan 25; [Epub ahead of print] 13. Kanazawa A, Kawamura Y, Sekine A, Iida A, Tsunoda T, Kashiwagi A, Tanaka Y, Babazono T, Matsuda M, Kawai K, Iiizumi T, Fujioka T, Imanishi M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakamura Y, Maeda S.: Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. Diabetologia. 2005 Jun 4; [Epub ahead of print] 14. Maeda S, Tsukada S, Kanazawa A, Sekine A, Tsunoda T, Koya D, Maegawa H, Kashiwagi A, Babazono T, Matsuda M, Tanaka Y, Fujioka T, Hirose H, Eguchi T, Ohno Y, Groves CJ, Hattersley AT, Hitman GA, Walker M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Kamatani N, McCarthy MI, Nakamura Y.: Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J Hum Genet. 2005 Jun 7; [Epub ahead of print] 15. Shimazaki A, Kawamura Y, Kanazawa A, Sekine A, Saito S, Tsunoda T, Koya D, Babazono T, Tanaka Y, Matsuda M, Kawai K, Iiizumi T, Imanishi M, Shinosaki T, Yanagimoto T, Ikeda M, Omachi S, Kashiwagi A, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakajima M, Nakamura Y, Maeda S.: Genetic Variations in the Gene Encoding ELMO1 Are Associated With Susceptibility to Diabetic Nephropathy. Diabetes. 54:1171-8, 2005. 16. Hara K, Ninomiya Y, Uchida M, Kawasaki F, Matsuda M, Matsuki M, Kaku K: Instruction and acceptance of patients during the introduction of the injector (OptiPen® Pro 1) from Novo FlexPen system. [Iryo Yakugaku] 31(8):652-658, 17. Matsuda M, Kawasaki F, Inoue H, Kanda Y, Yamada K, Harada Y, Saito M, Eto M, Matsuki M, Kaku K:Possible contribution of adipocytokines on diabetic neuropathy. Diabetes Res Clin Pract. 66 Suppl 1:S121-3, 2004. 18. Kanda Y, Yamada K, Harada Y, Kawasaki F, Saito M, Inoue H, Matsuda M, Katsuki M, Eto M, and Kaku K: Clinical Parameters for Predicting Possibility of Insulin Therapy Withdrawal in Patients with Type 2 Diabetes Mellitus J.Jan Diab. Soc. 47(4):271-275, 2004. [Japanese] 19. Fumiko Kawasaki, Masafumi Matsuda, Yukiko Kanda, Hiroshi Inoue, and Kohei Kaku: Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice. Am J Physiol Endocrinol Metab. 288:E510-518, 2005. 20. Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, Defronzo RA.: Beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab. 90:493-500, 2005. 21. Yukiko Kanda, Kayo Yamada, Yumiko Harada, Fumiko Kawasaki, Mieko Saito, Hiroshi Inoue, Masafumi Matsuda, Michihiro Matsuki, Masaaki Etou, Kohei Kaku: Clinical Parameters for Predicting Possibility of Insulin Therapy Withdrawal in Patients with Type 2 Diabetes Mellitus. J. Japan Diab. Soc. 47: 271-275, 2004. [Japanese with Einglish Abstract] 22. Kanazawa A, Tsukada S, Sekine A, Tsunoda T, Takahashi A, Kashiwagi A, Tanaka Y, Babazono T, Matsuda M, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakamura Y, Maeda S.: Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes. Am J Hum Genet. 75:832-43, 2004 23. Saito M, Eto M, Nitta H, Kanda Y, Shigeto M, Nakayama K, Tawaramoto K, Kawasaki F, Kamei S, Kohara K, Matsuda M, Matsuki M, Kaku K.: Effect of apolipoprotein E4 allele on plasma LDL cholesterol response to diet therapy in type 2 diabetic patients. Diabetes Care. 27:1276-80, 2004 24. M. Matsuda, F. Kawasaki, K. Yamada Y. Kanda, M. Saito, M. Eto, M. Matsuki, and K. Kaku: Impact of Adiposity and Plasma Adipocytokines on Diabetic Angiopathies in Japanese Type 2 Diabetic Subjects. Diabetic Medicine 21(8):881-8, 2004 25. Hamano M, Saito M, Eto M, Suda H, Matsuda M, Matsuki M, Yamamoto S, Kaku K: Serum smyroid A (SAA), C-reactive protein and remnant-like lipoprotein particles (RLP)-cholesterol in type 2 diabetic patients with coronary heart disease. Ann. Clin. Biocem. 41(Pt 2):125-9, 2004 26. Kaku K, Kawasaki F, Kanda Y, Matsuda M: Retained capacity of glucose- mediated insulin secretion in patients with type 2 diabetes mellitus inversely correlates with the duration of diabetes. Diabetes Res Clin Pract 64:221-3, 2004 27. Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, DeFronzo RA.: Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia. 47:31-9, 2004 28. Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Pettiti M, Natali A, Mari A, DeFronzo RA.: Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance. Diabetologia. 46:1211-9, 29. Ferrannini E, Gastaldelli A, Matsuda M, Miyazaki Y, Pettiti M, Glass L, DeFronzo RA.: Influence of ethnicity and familial diabetes on glucose tolerance and insulin action: a physiological analysis. J Clin Endocrinol Metab. 88:3251-7, 30. Saito M, Eto M, Nisimatsu S, Kume Y, Kawasaki H, Yoneda M, Matsuda M, Matsuki M, Kaku K: Case of familial hypoalphalipoproteinemia, type 2 diabetes mellitus and markedly advanced atherosclerosis with ABCAlexon 4 minus transcript in macrophages Nippon Naika Gakkai Zasshi. 91(9):2762-4, 2002. 31. Gastaldelli A, Miyazaki Y, Pettiti M, Matsuda M, Mahankali S, Santini E, DeFronzo RA, Ferrannini E: Metabolic effects of visceral fat accumulation in type 2 diabetes. J Clin Endocrinol Metab 87:5098-5103 2002 32. Matsuda M, Kawasaki F, Mikami Y, Takeuchi Y, Saito M, Eto M, Kaku K: Rescue of beta-cell exhaustion by diazoxide after the development of diabetes mellitus in rats with streptozotocin induced diabetes Eur J Pharm 453:141-148, 2002. 33. Matsuda M, DeFronzo RA, Glass L, Consoli A, Giordano M, Bressler P, Del Prato S: Glucagon dose response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals Metabolism 34. Miyazaki Y, Mahankali A, Matsuda M, Mahankali S, Hardies J, Cusi K, Mandarino LJ, DeFronzo RA: Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients J Clin 35. Eto M, Saito M, Okada M, Kume Y, Kawasaki F, Matsuda M, Yoneda M, Matsuki M, Takigami S, Kaku K: Apolipoprotein E genetic polymorphism, remnant lipoproteins, and nephropathy in type 2 diabetic patients Am J Kidney 36. Miyazaki Y, Matsuda M, DeFronzo RA: Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes Diabetes Care 37. Miyazaki Y, Mahankali A, Matsuda M, Glass L, Mahankali S, Ferrannini E, Cusi K, Mandarino LJ, DeFronzo RA: Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone Diabetes Care 24:710-719, 2001. 38. Miyazaki Y, Glass L, Triplitt C, Matsuda M, Cusi K, Mahankali A, Mahankali S, Mandarino LJ, DeFronzo RA: Effect of rosiglitazone on glucose and non- esterified fatty acid metabolism in Type II diabetic patients Diabetologia 39. Iozzo P, Pratipanawatr T, Pijl H, Vogt C, Kumar V, Pipek R, Matsuda M, Mandarino LJ, Cusi KJ, DeFronzo RA: Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis Am J Physiol Endocrinol Metab 280:E712-E719, 2001. 40. Matsuda M, Hiramatsu S, Teramoto F, Kawasaki F, Kaku K: Sparing of fat during basal metabolism in female diabetic patients Proceedings of the annual meeting of Japanese society of molecular medicine 37:26, 2000. 41. Kaku K, Matsuda M, Urae A, Irie S: Pharmacokinetics and pharmacodynamics of insulin aspart, a rapid-acting analog of human insulin, in healthy Japanese volunteers Diabetes Res Clin Pract 49:119-126, 2000. 42. Liu Y, Fox PT, Liu H-L, Mao J, Matsuda M, Gao J-H: Temporal clustering analysis for tracing the maximal fMRI response in human brain Proc Intl Soc Mag Reson Med 8:238 2000. 43. Pijl H, Ohashi S, Matsuda M, Miyazaki Y, Mahankali A, Kumar V, Pipek R, Iozzo P, Lancaster JL, Cincotta AH, DeFronzo RA: Bromocriptine: a novel approach to the treatment of type 2 diabetes. Diabetes Care 23:1154-1161, 2000. 44. Insulin Sensitivity Indexes Calculated From Oral Glucose Tolerance Test Data; Response to Belfiore Matsuda M, DeFronzo RA Diabetes Care 23:1595-1596, 45. Matsuda M, DeFronzo RA: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp Diabetes Care 46. Matsuda M, Liu Y, Mahankali S, Pu Y, Mahankali A, Wang J, DeFronzo RA, Fox PT, Gao JH: Altered hypothalamic function in response to glucose ingestion in obese humans Diabetes 48:1801-1806, 1999. 47. Matsuda M, Mandarino L, DeFronzo RA: Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats Metabolism 48:725-731, 1999. 48. Del Prato S, Matsuda M, Simonson DC, Groop LC, Sheehan P, Leonetti F, Bonadonna RC, DeFronzo RA: Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance. Diabetologia 40:687-97, 49. Bahl,J.J., Matsuda,M., DeFronzo,R.A., and Bressler,R.: In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase. Biochemical Pharmacology 53:67-74, 1997. 50. Kristal,B.S., Jackson,C.T., Chung,H.-Y., Matsuda,M., Nguyen,H.C., and Yu,B.P.: Defects at Center P Underlie Diabetes-Associated Mitochondrial Dysfunction: Free Radical Biology and Medicine 22:823-833, 1997. 51. Bressler,P., Bailey,S.R., Matsuda,M., DeFronzo,R.A.: Insulin Resistance and Coronary Artery Disease. Diabetologia 39:1345-1350, 1996. 52. Kristal,B.S., Matsuda,M., and Yu,B.P.: Abnormalities in the Mitochondrial Permeability Transition in Diabetic Rats. Biochem.Biophys.Research Comm. 222:519-523, 1996. 53. Giordano,M., Matsuda,M., Sanders,L., Canessa M.L., and DeFronzo,R.A.: The effects of angiotensin-converting enzyme inhibitors, Ca2+ channel antagonists, and ?-adrenergic blockers on glucose and lipid metabolism in NIDDM patients with hypertension. Diabetes 44:665-671, 1995 54. DelPrato,S., Leonetti,F, Simonson,D.C., Sheehan,P., Matsuda,M., and DeFronzo,R.A.: Effect of sustained physiologic hyperinsulinemia and hyperglycemia on insulin secretion and insulin sensitivity in man. Diabetologia 55. Masafumi Matsuda: In vivo techniques for clinical studies of glucose metabolism. Bulletin of the Yamaguchi Medical School 41: 155-168, 1994. 56. Bonora,E., Bonadonna,R., DelPrato,S., Gulli,G., Matsuda,M., Solini,A., and DeFronzo,R.A.: In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension. Diabetes 42:764-772,1993. 57. Masafumi Matsuda, Kaku,K., Aoki,M., Inoue,H., and Kaneko,T.: Sulfonylurea enhances insulin-induced acetyl-CoA carboxylase activity in rat adipocytes. Horm.Met.Res.23:209-212, 1991. 58. Matsutani,A., Kaku,K., Aoki,M., Mori,K., Matsuda,M. and Kaneko,T.: Possible mechanism of proteolysis for the extra-pancreatic action of tolbutamide. Diabetes Res Clin Pract 12:35-40, 1991. 59. Shinohara,K., Ayame,H., Tanaka,M., Matsuda,M., Ando,S. and Tajiri, M.: Increased production of tumor necrosis factor-? by peripheral blood mononuclear cells in the patients with aplastic anemia. Am.J.Hematol. 37:75-79, 1991. 60. Kenji Shinohara, Tanaka,M., Matsuda,M., Tanaka,H., Fujii,Y., Yamada,K. and Kaneko,T.: Gamma interferon production and two-color fluorescence flow cytometry analysis of peripheral blood mononuclear cells in allogenic bone marrow transplant recipients. Acta Haematol Jpn. 53: 76-83, 1990. 61. Shinohara,K., Ayame,H., Kodama,T. and Matsuda,M.: Study of suppression of hematopoiesis in the patients with hepatitis. Japanese Archives of Internal Medicine 37:159-164, 1990. 62. Hiroyuki Tanaka, Shinohara,K., Tanaka,M., Matsuda,M. and Kaneko,T: Flow cytometry analysis and gamma interferon production of peripheral blood mononuclear cells in aplastic anemia. Jpn.Arch.Int.Med. 36: 385-391, 1989. 63. Masafumi Matsuda and Kaneko,T.: Application of MUMPS for the management of diabetic patients on a lap-top computer. Japan J.Med.Info. 8: 235-244, 1988. 64. Matsuda,M., Fujii,Y., Kaneko,T., Juji,T. and Kaihara,S.: Data management system for HLA on PC-9801 ( a desk top personal computer ) and PC-98LT ( a lap-top computer ). J. C. Med. Info. 8: 257-258, 1988. 65. Masako Tsuchiya, Kaku,K. Matsuda,M., Kaneko,T. and Yanaihara,N: Demonstration of receptors specific for peptide N-terminal histidine and C- terminal isoleucine (PHI) using rat PHI and rat dispersed pineal cells. Biomedical Research 8: 45-51, 1987. 66. Shinya Fujii, Matsuda,M., Okuya,S., Yoshizaki,Y., Kora-Miura,Y. and Kaneko,T.: Fructose-6-phosphate,2-kinase activity in human erythrocytes. 67. Yukari Kora-Miura, Fujii,S., Matsuda,M., Yutaka,S., Kaku,K. and Kaneko,T.: Electrophoretic determination of fructose-6-phosphate,2-kinase. Anal.Biochem. 68. Kohei Kaku, Fujii,S., Ando,S., Yaga,K., Inoue,M., Inoue,Y., Okubo,M., Fujii,Y., Matsutani,A., Azuno,Y., Matsuda,M., Sato,Y., Mori,K., Tanaka,H., Tanaka,M., Kaneko,T. and Ariyoshi,K.: Relationship between clinical efficiency of cefoperazone and the value of area under the time concentration curve in infectious diseases. The Japanese Journal of Antibiotics 40: 77-85, 1987. 69. Masafumi Matsuda, Kaku,K., Matsutani,A., Tsuchiya,M., Okuya,S. and Kaneko,T.: DG-5128 modification of the liver fructose 2,6-bisphosphate concentration suppressed by glucagon and epinephrine. Peptide Hormones in Pancreas 7: 229-233, 1987. 70. Masafumi Matsuda and Kaku,K.: Tissue metabolic specificity to insulin and sulfonylureas and its actions. Journal of Japan Diabetes Society 30:1193-1194, 71. Shinya Fujii, Matsumura,S., Yaga,K., Kaku,K., Ishida,Y., Matsuda,M., Yoshizaki,Y., Azuno,Y. and Kaneko,T.: Therapy of hypertension in the diabetic: Effectiveness of Metoprolol (Seloken). [Shinyakuto Rinsho] 36: 1636-1643, 1987. 72. Kohei Kaku, Matsuda,M., Matsutani,A. and Kaneko,T.: Effect of tolbutamide on fructose-6-phosphate,2-kinase and fructose-2,6-bisphoshatase in rat liver. Biochem.Biophys.Res.Commun. 139: 687-692, 1986. 73. Masafumi Matsuda, Kaku,K., Hatao,K. and Kaneko,T.: Tolbutamide and insulin stimulation of fructose-2,6-bisphosphate formation in hepatocytes differ. Diabetes Research and Clinical Practice 2: 347-335, 1986. 74. Masafumi Matsuda, Kaku,K. and Kaneko,T.: Regulation of muscle fructose 2,6- bisphosphate levels by sulfonylureas. Endocrinol.Japon. 33: 913-917, 1986. 75. Hiroko Sasaki, Fujii,S., Azuno,Y., Matsuda,M., Yoshizaki,Y., Yaga,K., Kaku,K. and Kaneko,T.: Clinical evaluation of treatment with intravenous tobramycin for serious infections. Chemotherapy 34: 271-275, 1986. 76. Kohei Kaku, Tsuchiya,M., Matsuda,M., Inoue,Y., Kaneko,T. and Yanaihara,N.: Light and agonist alter vasoactive intestinal peptide binding and intracellular accumulation of adenosine 3'5'-monophosphate in the rat pineal gland. 77. Katsuhiro Hatao, Kaku,K., Matsuda,M., Tsuchiya,M. and Kaneko,T.: Sulfonylurea stimulates liver fructose 2,6-bisphosphate formation in proportion to its hypoglycemic action. Diabetes Research and Clinical Practice 1: 49-53, 1985. 78. Shigeichi Matsumura, Tsuchiya,M., Matsuda,M., Hatao,K., Yaga,K., Kaku,K. and Kaneko,T.: The influence of glucomannan intake on the intestinal absorption of trace elements. Yamaguchi Medical Journal 34: 67-71, 1985. 79. Masafumi Matsuda, Inoue,M., Tajiri,M., Matsumoto,N. and Kaneko,T.: Two cases of agranulocytosis during the medication of cinepazide. Japanese 1. Matsuda M: Measuring and estimating insulin resistance in clinical and research settings. Nutrition, Metabolism & Cardiovascular Diseases 20:79- 2. Matsuda M: Diagnosis of insulin resistance [Hormone to Rinsho] 53(11):1159- 3. Matsuda M: HOMA index [Seijinbyo to Seikatsu Shukanbyo] 35(8):887-890, 4. Matsuda M, Kaku K: Rosiglitazone [Sogo Rinsho] 54:1568-1573, 2005. 5. Matsuda M: How to diagnose Metabolic Syndrome Medical Practice 21:2005- 6. Matsuda M: Insulin Detemir. Practice 21:284-288, 2004. [Japanese] 7. Matsuda M: Glucose clamp. Diabetes Frontier 14:304-308, 2003. [Japanese] 8. Matsuda M, Kaku K: Cutting edge of pathophysiology and therapy in Diabetes mellitus; Assessment of Insulin Resistance. Current Therapy 21: 27-31, 2003. 9. Matsuda M, Kaku K: Repaglinide (NN-623). [Nippon Rinsho] 60 Suppl 9:555-8, 10. Matsuda M: Ready to use EBM in Diabetes Mellitus. [Rinshoi] 28:1930-1938, 11. Matsuda M, Kaku K: Insulin Aspart, Its Features and Points of Therapy. 12. Matsuda M, Kaku K: Therapy in Diabetes Complications, Management of Microangiopathy that derange QOL. Mebio 19:65-69, 2002. [Japanese] 13. Matsuda M, Kaku K: Therapy of dyslipidemia. [Shinyaku to Chiryo] 51:23-25, 14. Matsuda M: Assessment of Insulin Resistance. Diabetes Frontier 11:635-645, 15. Matsuda M, Kaku K.: Drug Therapy [Igaku to Yakugaku] 43:194-202, 2000. 16. Matsuda,M, Kaku,K.: Basic and application of sulphonylurea drugs considering the mechanism of action. [Horumon to Rinsho] 47:88-94, 1999. [Japanese] 17. Kaku,K, Matsuda,M: Role of alpha-glucosidase inhibitor on the treatment of type 2 diabetes mellitus. [Naibunpi Tounyoubyou-ka] 8: 355-360, 1999. 18. DeFronzo,R.A., Matsuda,M., and Barrett,E.J.: Diabetic ketoacidosis; A combined metabolic-nephrologic approach to therapy. Diabetes Reviews 2:209-238, 1994 19. Masafumi Matsuda and Kaneko,T.: Antidiabetic Agents [Saishin Igaku] 45: 20. Masafumi Matsuda and Kaku,K.: Extra-pancreatic action of sulfonylureas. Diabetes Frontier 1:609-614, 1990. [Japanese] 21. Masafumi Matsuda: Drug therapy, hypoglycemic reagents. [Rinshooi] 15: 424- 22. Masafumi Matsuda and Kaneko,T.: Various factors related to carbohydrate metabolism. Gastro-entero-pancreatic hormones. [Nippon Rinsho] 47: 2415-2419, 23. Masafumi Matsuda and Kaneko,T.: Indication of sulfonylureas - recent point of view - Journal of Clinical Science 24: 1428-1433, 1988. [Japanese] 24. Toshio Kaneko and Matsuda,M.: Mechanism of hypoglycemic action of sulfonylurea. Diabetes Journal 15:1-8, 1987. [Japanese] 5. Abstracts (English Presentation only upto 2005) 1. Matsuda M, Kawasaki F, Kanda Y, Kishimoto H, Sumiko H, Shimoda M, Shigeto M, Tawaramoto K, Kohara K, Nakayama K, Matsuki M, Kaku K: Pioglitazone modifes not only distribution but also density of adipose tissue in type 2 diabetic patients Diabetologia 48 (suppl 1): A279, 2005. 2. Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K: ATP-sensitive potassium channel independent pathway is involved in action mechanism of meglitinides, but not sulfonylureas Diabetologia 48 (suppl 1): A174, 2005. 3. Kanda Y, Kohara K, Tawaramoto K, Kawassaki F, Kotani M, Matsuda M, Nakashima K, Kaku K: Cellular mechanism of pancreatic beta cell dysfunction in diabetic db/db mice; evidence for deranged gene expression profiles of islet cells obtained by laser capture microdissection Diabetologia 48 (suppl 1): A426, 2005. 4. Shigeto M, Katsuda M, Matsuda M, Ohkuma S, Kaku K: First phase of glucose- stimulated insulin secretion from pancreas consists of three different pathways including ATP-sensitive potassium channel Diabetes 54 (suppl1): A407, 2005 5. Mari A, Miyazaki Y, Matsuda M, Ferrannini E, DeFronzo RA: Thiazolidinediones improve beta-cell function in Type 2 diabetic patients: 6. Kanda Y, Matsuda M, Kawasaki F, Hamamoto S, Kaku K: Sulfonylurea Drugs Regulates Secretion and Production of Adipocytokines from 3T3-L1 Adipocytes. Diabetes 53 (suppl1): A97, 2004 (64th Sceintific Sessions of American Diabetes Association, Orlando, Florida, 6/4-8, 2004) 7. Masafumi Matsuda, Fumiko Kawasaki, Makoto Shigeto, Kohei Kaku: Effects of dihydropyridine derivatives on insulin sensitivity in spontaneous hypertensive rats Diabetes 53 (suppl1): A312, 2004 (64th Sceintific Sessions of American Diabetes Association, Orlando, Florida, 6/4-8, 2004) 8. M.Saito, M.Eto, Y.Kanda, K.Yamada, F.Kawasaki, Y.Harada, H.Inoue, M.Matsuda, M.Matsuki, K.Kaku: Importance of remnant lipoproteins in diabetic nephropathy – lesson from apolipoprotein E genotype study. Diabetologia 2003. (16th International Diabetes Federation Congress, Paris, France, 8/24-29, 2003) 9. M.Matsuda, F.Kawasaki, H.Inoue, K.Kaku: Effect of spironolactone on insulin sensitivity in normal and fa/fa rats. Diabetes Metab 29(suppl 4):4S98, 2003. (16th International Diabetes Federation Congress, Paris, France, 8/24-29, 2003) 10. Masafumi Matsuda, Fumiko Kawasaki, Yukiko Kanda, Yumiko Harada, Mieko Saito, Hiroshi Inoue, Masaaki Eto, Michihiro Matsuki, Kohei Kaku: Impact of Adipocity through Plasma Adipocytokines on Diabetes Angiopathies in Japanese Type 2 Diabetic Subjects: Diabetes 52 (suppl1): A161, 2003 (63th Scientific Sessions of American Diabetes Association, New Orleans, 6/13-17, 2003) 11. Amalia Gastaldelli, Ele Ferrannini, Yoshinori Miyazaki, Masafumi Matsuda, Rlph DeFronzo: B-Cell Dysfunction and Glucose Intolerance: Results from the San Antonio Metbaolism (SAM) Study. Diabetes 52 (suppl1): A27, 2003 (63th Scientific Sessions of American Diabetes Association, New Orleans, 6/13-17, 2003) 12. Ralph DeFronzo, Amalia Gastaldelli, Yoshi Miyazaki, Masa Matsuda, Andrea mari, Ele Ferrannini: Critical Evaluation of Insulin Secretio in NGT, IGT, and T2DM Subjects. Diabetes 52 (suppl1): A335, 2003 (63th Scientific Sessions of American Diabetes Association, New Orleans, 6/13-17, 2003) 13. Saito M, Eto M, Kume S, Kawasaki F, Matsuda M, Yoneda M, Matsuki M, Takigami S, Kaku K: Apolipoprotein (apo) E2 promotes and apo E4 protects diabetic nephropathy - Importance of remnant lipoproteins. 14. Kawasaki F, Matsuda M, Inoue H, Niki I, Kaku K: revention of pancreatic β cell damage by pharmacological interventions in db/db mice in implications for glucolipotoxicity mechanism Diabetologia 45(suppl.2):A146, 2002. 15. Yoneda M, Matsuda M, Matsuki M, Eto M, Kaku K: New Approach for Blood Glucose Profile Stabilization by Predictive Glycemic Control System Diabetes 51(suppl.2):A127, 2002. 16. Gastaldelli A, Matsuda M, Miyazaki Y, Pettiti M, Defronzo R, Ferrannini E: Impaired Glucose Tolerance: Insulin Resistance or Insulin Deficiency? Diabetes 51(suppl.2):A583, 2002. 17. Matsuda M, Kawasaki F, Tamechika Y, DeFronzo RA, Kaku K: Contribution of the Pancreas, Peripheral Tissues, and Liver in the Increment in Plasma Glucose after Oral Glucose Load 62nd Scientific Sessions of American Diabetes Association (San Fransisco, USA) 2002 6.14-18 Diabetes 51(suppl.2): A331, 2002 18. Masafumi Matsuda, Fumiko Kawasaki, Kenji Kohara, Mieko Saito, Masaya Yoneda, Michihiro Matsuki, Masaaki Eto, Kohei Kaku: Carotid Intima-Media Thickness and Localization of Adiposity in Subjects with Type 2 Diabetes Mellitus. Diabetes 50(suppl.2): A98, 2001. (61th Scientific Sessions of American Diabetes Association, Philadelphia, 6/22-26, 2001) 19. Yoshi Miyazaki, Masafumi Matsuda, Archana Mahankali, Srikanth Mahankali, Kenneth Cusi, Laurence Mandarino, Ralph DeFronzo: Mechanism of Glucose-Lowering Effect by Rosiglitazone in Patients with Type 2 Diabetes. Diabetes 50(suppl.2): A126, 2001. (61th Scientific Sessions of American Diabetes Association, Philadelphia, 6/22-26, 2001) 20. Y. Miyazaki, A. Mahankali, M. Matsuda, S. Mahankali, K. Cusi, L.J. Mandarino, R.A. DeFronzo: Relationship between Visceral Fat and Enhanced Peripheral/Hepatic Insulin Sensitivity after Pioglitazone in Type 2 Diabetes. Diabetes 50(suppl.2): A126, 2001. (61th Scientific Sessions of American Diabetes Association, Philadelphia, 6/22-26, 2001) 21. Amalia Gastaldelli, Maura Petti, Eleonora Sanini, Ele Ferrannini, Masafumi Matsuda, Yoshinori, Miyazaki, Srikanth Mahankali, Archana Mahankali, Ralph A. DeFronzo: Influence of Ethnicity and Fat Distribution on Gluconeogenesis in Type 2 Diabetes. Diabetes 50(suppl.2): A46, 2001. (61th Scientific Sessions of American Diabetes Association, Philadelphia, 6/22-26, 2001) 22. Curtis Triplitt, Yoshinori Miyazaki, Archana Mahankali, Srikanth Mahankali, Shin-ichi Ohashi, Masafumi Matsuda, Kenith Cusi, Lawrence J. Mandarino, Ralph A. DeFronzo: Combination Therapy with Metformin and Troglitazone in Type 2 Diabetic Patients. Diabetes 50(suppl.2): A446, 2001. (61th Scientific Sessions of American Diabetes Association, Philadelphia, 6/22-26, 2001) 23. F. Kawasaki, M. Matsuda, K. Kohara, K. Kaku: Rescue of beta-cell exhaustion after the development of diabetes mellitus in db/db mice. Diabetologia 44 (Suppl 1): A147, 2001 (37th Annual Meeting of the European Association for the Study of Diabetes, Glasgow, United Kingdom, 9/9-13, 2001) 24. A Gastaldelli, M. Matsuda, Y. Miyazaki, R. DeFronzo and E. Ferrannini: Influence of Ethnicity and Familial Diabetes on peripheral and hepatic insulin action. Diabetologia 44 (Suppl 1): A1483, 2001 (37th Annual Meeting of the European Association for the Study of Diabetes, Glasgow, United Kingdom, 9/9- 25. Y. Miyazaki, L. Glass, C. Triplitt, M. Matsuda, K. Cusi, L.J. Mandarino, and R.A. DeFronzo: Effect of rosiglitazone on FFA and glucose metabolism in type 2 diabetic patients. Diabetologia 44 (Suppl 1): A37, 2001 (37th Annual Meeting of the European Association for the Study of Diabetes, Glasgow, United Kingdom, 26. M. Saito, M. Eto, F. Kawasaki, K. Kohara, M. Yoneda, M. Matsuda, M. Matsuki, K. Kaku: Effect of Apo-E2-remnant lipoproteins on PKC activity and TGF-b and protein matrix synthesis in mesangial cells. Diabetologia 44 (Suppl 1): A264, 2001 (37th Annual Meeting of the European Association for the Study of Diabetes, Glasgow, United Kingdom, 9/9-13, 2001) 27. MATSUDA M. et al.: Rescue of pancreatic b-cell exhaustion by pharmacological intervention in STZ-induced diabetic rats. Diabetologia , 2000 (36th EASD, 28. ETO M. et al.: Apolipoprotein E2 and E4 alleles and diabetic nephropathy. Diabetologia , 2000 (36th EASD, Jerusalem, Israel, Sep 17-21, 2000) 29. MIEKO SAITO, MASAAKI ETO, FUMIKO KAWASAKI, YASUO TAKEUCHI, MASAFUMI MATSUDA, KOHEI KAKU: Remnant-Like Particles (RLPs) from Type 2 Diabetic Patients with Apolipoprotein E2 Enhance Cholesteryl Ester Synthesis in Macrophages Diabetes 49 Supple 1:A270, 2000 (60th ADA, San 30. YOSHINORI MIYAZAKI, ARCHANA MAHANKALI, MASAFUMI MATSUDA, SRIKANTH MAHANKALI, KENNETH CUSI, LAWRENCE MANDARINO, RALPH A. DEFRONZO: Effect Of Pioglitazone On Abdominal Fat Distribution And Insulin Sensitivity In Patients With Type 2 Diabetes Mellitus (T2DM) Diabetes 49 Supple 1:A299, 2000 (60th ADA, San Antonio, June 9-13, 2000). 31. FUMIKO KAWASAKI, MASAFUMI MATSUDA, MIEKO SAITO, YASUO TAKEUCHI, MASAAKI ETO, KOHEI KAKU: Relationship between Insulin Resistance and Localization of Adiposity in Subjects with Type 2 Diabetes Mellitus Diabetes 49 Supple 1:A91, 2000 (60th ADA, San Antonio, June 9-13, 32. MASAFUMI MATSUDA, SATOKO HIRAMATSU, FUSAKO TERAMOTO, FUMIKO KAWASAKI, KOHEI KAKU: Sparing of Fat in Lean Female Subjects with Type 2 Diabetes Mellitus during Basal State Diabetes 49 Supple 1:A92, 2000 (60th ADA, San Antonio, June 9-13, 2000). 33. ARCHANA MAHANKALI, YOSHINORI MIYAZAKI, MASAFUMI MATSUDA, KENNETH CUSI, LAWRENCE MANDARINO, RALPH DEFRONZO: Effect Of Pioglitazone On Glucose Tolerance And Insulin Sensitivity In Diet-Controlled Type 2 Diabetic Subjects Diabetes 49 Supple 1:A116, 2000 (60th ADA, San Antonio, June 9-13, 2000). 34. YOSHINORI MIYAZAKI, ARCHANA MAHANKALI, MASAFUMI MATSUDA, KENNETH CUSI, LAWRENCE MANDARINO, RALPH A. DEFRONZO: Effect Of Pioglitazone On Glucose Metabolism In Sulfonylurea-Treated Patients With Type 2 Diabetes Diabetes 49 Supple 1:A117, 2000 (60th ADA, San Antonio, June 9-13, 2000). 35. Liu, Y., Fox, P.T., Liu H-L, Mao J, Matsuda M, J-H Gao: Temporal Clustering Analysis for Tracting the Maximal fMRI Response in Human Brain. Proc. Intl. Soc. Mag. Reson. Med 8: 238, 2000. 36. Matsuda,M., Liu,Y., Mahankali, S., Pu Y., Mahankali, A., Wang, J., DeFronzo, R.A., Fox, P.T., Gao, J.-H.: Altered Brain Function after Intravenous Glucose Infusion in Humans. Diabetes 48 (supple. 1): A27, 1999 (59th ADA, San Diego, 37. Matsuda,M., DeFronzo, R.A.: Insulin Sensitivity Indices Obtained from Oral Glucose Tolerance Test: Comparison with Euglycemic Insulin Clamp. Diabetes 48 (supple. 1): A79, 1999 (59th ADA, San Diego, 6/19-22, 1999) 38. Matsuda,M, Ohashi,S, Kaku,K, DeFronzo,RA: Relationship between insulin sensitivity and abdominal fat measured by MRI in obese diabetic subjects. Journal of Japan Diabetes Society 42(suppl 1):S275, 1999 (4th JDS, Yokohama 39. Kaku,K, Kawasaki,F, Matsuda,M, Takeuchi,Y, Eto,M: Effect of correction of glucose toxicity on glucose tolerance and insulin secretion in type 2 diabetes mellitus. Journal of Japan Diabetes Society 42:S165, 1999 (4th JDS, Yokohama 5/13-15, 1999) 40. Okada,M, Eto,M, Saito,M, Kawasaki,F, Matsuda,M, Kaku,K: Effect of apoE2 and E4 genotype and hyperlipidemia on body weight and plasma glucose in type 2 diabetic subjects. Journal of Japan Diabetes Society 42:S108, 1999 (4th JDS, 41. M.Matsuda, Y.Liu, S.Mahankali, Y.Pu, A.Mahankali, J.Wang, R.A.DeFronzo, P.T.Fox, J.H.Gao: Brain Function After glucose Intake in Obese Humans. 1998 APS conference, The Paraventricular Nucleus of the Hypothalamus: A Crossroads of Integrative Physiology, Pysiologist 41:372, 1998 (San Antonio, 42. Matsuda, M.: Synergistic effect of Magnesium and Vanadate on Insulin Action in Nondiabetic and Diabetic Rats. Diabetes 47 (supple. 1): A288, 1998 (58th ADA, Chicago, 6/13-16, 1998) 43. J.-H. Gao, P.T. Fox, Y.J. Liu, Y. Pu, R.A. DeFronzo, M. Matsuda: FMRI of the Hypothalamic Region in Subjects with Obesity, NeuroImaging, S926 (1998) 44. Matsuda,M., Sugaya, K., Mandarino,L.J., Marusawa,H., and DeFronzo,R.A.: Abnormal vitamin D binding protein fragment in blood of first degree relatives of patients with type 2 diabetes mellitus. Diabetologia 40(supple 1):A169, 1997. (16th International Diabetes Federation Congress, Helsinki, 7/20 - 25, 1997) 45. Matsuda, M., DeFronzo, R.A.: Relationship between insulin sensitivity in adipose tissue, liver, muscle, and components of the insulin resistance syndrome. Diabetes 46 (suppl. 1): 68A, 1997 (57th ADA, Boston, 6/21 - 24, 1997) 46. Matsuda,M., and DeFronzo, R.A.: Isolation of Hepatic and Peripheral Insulin Sensitivity: Application to the Investigation of Inherited or Acquired Defects in NIDDM. Diabetes 45 (suppl. 1): 17A, 1996 (56th ADA, San Francisco, 6/8 - 11, 1996) 47. Matsuda,M., Lee,N., and Shank,M.L.: Increased Hepatic Glucose Production in Subjects with Family History of NIDDM. Diabetes 44(suppl. 1):108A, 1995. (55th 48. Matsuda,M., Shank,M., Malasanos,T.H., and Mandarino,L.: Effect of Free Fatty Acid (FFA) on Intracellular Glucose Oxidation (GOX) and Glycogen Synthesis (GS) in NIDD subjects. Diabetes 43 (supple. 1):49A, 1994. (54th ADA, New Orleans, 6/11- 14, 1994) 49. Giordano,M., and Matsuda,M.: Effect of Captopril (CAP) Nifedipine (NIF) and Doxazosin (DOX) on Insulin Sensitivity in Non-Insulin Dependent Diabetic (NIDD) Hypertensive Patients. Diabetes 43 (supple. 1):79A, 1994. (54th ADA, 50. Matsuda,M., Banduch,D., and DeFronzo,R.A.: Effect of Magnesium Vanadate (MgV) on Glucose Metabolism in Normal and STZ-induced Diabetic Rats. (15th 51. Lee,N., DeFronzo,R.A., Mandarino,L., Bressler,P., and Matsuda,M.: Effect of Misoprostol (PGE1) on Glucose Metabolism in NIDDM and Control Subjects. Misoprostol and Eicosanoids Research symposium, Deerfeild, Illinois, 4/14-15, 52. Matsuda,M., Banduch,D.: Effect of IGF-I on Protein Metabolism in Diabetic and Control Rats. Diabetes 42 (suppl.1) 39A (53rd ADA, Las Vegas, 5/12-5/15, 1993) 53. Sieste,J.K. and Matsuda,M.: Time Dependent Action of Insulin on Glucose Metabolism in Conscious Normal Rats. Diabetes 42 (suppl.1):74A (53rd ADA, 54. Gulli,G., Pendergrass,M.L., Consoli,A., Matsuda,M., and DeFronzo,R.A.: Randle Cycle is Operative in the Onset of Insulin Resistance During Short Extension of the Postabsorptive State. Diabetologia 36 (suppl.1):A124, 1993 (29th EASD, Istanbul, Turkey, 9/6-10, 1993) 55. Matsuda,M., Banduch,D. and Bressler,R.: Mechanism of Action of Hydrocinnamic Acid. Diabetes 41(suppl.1):188A, 1992. (52nd ADA, San Antonio, USA, 6/20-23, 1992) 56. DelPrato,S., Malassanos,T., Bonora,E. and Matsuda,M.: Quantitation of Intracellular Pathway of Glucose Disposal in Normal and Obese Subjects. Diabetes 41 (suppl.1):73A, 1992. (52nd ADA, San Antonio, USA, 6/20-23, 1992) 57. Malasanos,TH, Matsuda,M. and DeFronzo,R.A.: Mechanism of Insulin Resistance During Sustained Free Fatty Acid Elevation in Normal Man. (Diabetes and Atherosclerosis, 2nd International Symposium, Karlovy Vary, Czechoslovakia, 9/5-7, 1992) 58. Matsuda,M., Consoli,A., Bressler,P., DeFronzo,R.A. and DelPrato,S.: Sustained Response of Hepatic Glucose Production (HGP) to Glucagon in Type 2 Diabetic Subjects. Diabetologia 35 (suppl.1):A37, 1992. (28th EASD, Prague, 59. Gulli,G., DelPrato,S., Bonadonna,R., Matsuda,M. and DeFronzo,R.A.: Euglycemic insulin clamp (EIC) and negative hepatic glucose production (HGP):A revaluation. Diabetologia 35 (suppl.1):A28, 1992. (28th EASD, Prague, Czechoslovakia, 9/8-11, 1992) 60. Matsuda,M., Kaneko,T. and DeFronzo,R.A.: Quantitation of Intracellular Pathways of Glucose Disposal in Normal and Obese Subjects. Journal of Japan Diabetes Society 35(suppl.1):156, 1992 (35th JDS, Kumamoto, 5/14-16, 1992) 61. Kaku,K., Aoki,M, Inoue,K, Matsuda,M., Hatao,K, Matsutani,A and Kaneko,T.: Activity of liver 6-phosphofructo-2-kinase/fructose-2,6-bishosphate and its regulation by tolbutamide. Journal of Japan Diabetes Society 35(suppl.1):216, 1992 (35th JDS, Kumamoto, 5/14-16, 1992) 62. Kaku,K., Inoue,H., Aoki,M., Matsuda,M., Matsumura,S. and Kaneko,T.: Regulation of Liver 6-phosphofructo-2-kinase activity and mRNA level by insulin, vanadate and sulfonylurea. Diabetes 40(suppl.1):97A, 1991. (14th IDF, 63. Aoki,M., Inoue,H., Matsuda,M., Kaku,K. and Kaneko,T.: Effect of tolbutamide on cyclic AMP-dependent protein kinase in the regulation of hepatic 6- phosphofructo-2-kinase activity. Diabetes 40(suppl.1):103A, 1991. (14th IDF, Washington,DC, USA, 6/23-28,1991) 64. Gulli,G., Bonadonna,R.C., Matsuda,M., Del Prato,S. and DeFronzo,R.A.: Hyperinsulinemia versus changes in arterial substrate concentration: which horse is pulling the cart? Diabetes 40(suppl.1):156A, 1991. (14th IDF, Washington,DC, USA, 6/23-28, 1991) 65. Aoki,M., Inoue,H, Matsuda,M., Hatao,H., Kaku,K., Kaneko,T.: Mechanism of Activation to 6-phosphofructo-2-kinase by tolbutamide -cAMP-dependent protein kinase-. Journal of Japan Diabetes Society 34(suppl.1):235, 1992 (34th JDS, 66. Aoki,M., Matsutani,A., Mori,K., Matsuda,M., Kaku,K. and Kaneko,T.: Mechanism of extra-pancreatic action of sulfonylureas - trypsin-like protease activities. Journal of Japan Diabetes Society 32(Suppl.1):101, 1989. (32nd JDS, 67. Mori,K., Aoki,M., Harada,Y., Nagasaka,Y., Matsuda,M., Matsutani,A., Kaku,K. and Kaneko,T.: Extra-pancreatic action of sulfonylureas in STZ-induced diabetic rats. Journal of Japan Diabetes Society 32 (Suppl.1): 102, 1989. (32nd JDS, Kanazawa, 4/20-22,1989) 68. Harada,Y., Okubo,M., Hatao,M., Matsuda,M. and Kaneko,T.: Regulation of pineal function by vasoactive intestinal polypeptide, helodermin and galanin. Biomedical Research 13(suppl.1): ,1988. (The Seventh International Symposium on Gastrointestinal Hormones, Shizuoka,Japan, 11/1-4, 1988) 69. Matsuda,M., Mori,K., Matsutani,A., Okubo,M., Kaku,K. and Kaneko,T.: Regulation of acetyl-CoA carboxylase in rat hepatocytes and adipocytes by sulfonylureas. Journal of Japan Diabetes Society 31(Suppl.1): , 1988. (31st JDS, Tokyo, 5/26-28,1988) 70. Matsutani,A., Mori,K., Matsuda,M., Kora,Y., Kaku,K. and Kaneko,T.: Exptra- pancreatic action of sulfonylureas: comparison of HB-420 and HOE-490. Journal of Japan Diabetes Society 31(Suppl.1): , 1988. (31st JDS, Tokyo, 5/26-28,1988) 71. Matsuda,M., Tanizawa,Y., Okuya,S., Harada,Y., Yaga,K., Fujii,S. and Kaneko,T.: Use of MUMPS language on the lap-top computers at a diabetic clinic. Journal of Japan Diabetes Society 31(Suppl.1): , 1988. (31st JDS, Tokyo, 5/26-28,1988) 72. Matsuda,M., Hatao,K., Nagasaka,Y., Fujii,Y., Fujii,S. Ishida,Y., Kaku,K. and Kaneko,T.: Variation of F-2,6-P2 levels in leukocytes in STZ-diabetic rats and its significance. Journal of Japan Diabetes Society 31(Suppl.1): , 1988. (31st JDS, 73. Fujii,S., Kora,Y., Matsuda,M., Sato,H, Kaku,K. and Kaneko,T.: Polyacrylamide gel electrophoresis of fructose-6-phosphate, 2-kinase. Journal of Japan Diabetes Society 31(Suppl.1): , 1988. (31st JDS, Tokyo, 5/26-28,1988) 74. Matsuda,M.: Management of graphic databases by MUMPS. Proceedings of 15th MUG-J Meeting:119,1988. (15th MUG-J Meeting, Nagoya, Dec.,1988) 75. Matsuda,M. and Kaku,K.: Differences of insulin action and sulfonylureas in the tissues. Journal of Japan Diabetes Society 30(Suppl.1):137, 1987. (30th JDS, 76. Okuya,S., Matsuda,M., Tsuchiya,M., Fujii,S. and Kaneko,T.: Regulation of F- 2,6-P2 levels in human mono-nuclear cells. Journal of Japan Diabetes Society 30(Suppl.1): 384, 1987. (30th JDS, Kyoto, 1987) 77. Kaku,K., Matsuda,M., Miura,Y., Matsutani,A., Yaga,K and Kaneko,T.: Activation of liver fructose-6-phosphate, 2-kinase by tolbutamide. Journal of Japan Diabetes Society 29(Suppl.2):214, 1986. (29th JDS, Ube, Yamaguchi, 78. Matsuda,M., Matsutani,A., Yaga,K., Kaku,K. and Kaneko,T.: Regulation of muscle F-2,6-P2 levels by sulfonylureas. Journal of Japan Diabetes Society 29(Suppl.2):215, 1986. (29th JDS, Ube, Yamaguchi, 1986) 79. Yaga,K., Kaku,K., Tsuchiya,M., Matsuda,M., Hatao,K., Inoue,Y., Okubo,M., Matsumura,S. and Kaneko,T.: The meaning of insulin receptor analysis and the determination of blood ketone bodies in ketosis-prone diabetes. Journal of Japan Diabetes Society 29(Suppl.2):210, 1986. (29th JDS, Ube, Yamaguchi, 1986) 80. Kaneko,T., Hatao,K., Tsuchiya,M., Matsuda,M. and Kaku,K.: Sulfonylurea stimulates liver fructose-2,6-bisphosphate formation in proportion to its hypoglycemic action. Diabetes Res.Clin.Pract. 1:Suppl.1: ,1985. (12th IDF, 81. Kaku,K., Matsuda,M., Tsuchiya,M., Hatao,K. and Kaneko,T.: Tolbutamide stimulation of F-2,6-P2 formation is independent of insulin. Diabetes Res.Clin.Pract 1:Suppl.1: , 1985 (12th IDF, Madrid, Spain, 9/26,1985) 82. Kaku,K., Tsuchiya,M., Matsuda,M., Hatao,K., Inoue,Y. and Kaneko,T.: Regulation of pineal body by VIP - Regulation of VIP-receptor adenyl cyclase system by photo stimulation. Folia Endocrinologica Japonica 61:428,1985. (58th Japan Endocrine Society, Nagoya, 5/14-16,1985) 83. Matsuda,M., Tsuchiya,M., Hatao,K., Miura,Y., Kaku,K. and Kaneko,T.: Regulation of liver F-2,6-P2 levels by tolbutamide, insulin and glucagon. Journal of Japan Diabetes Society 28:443, 1985. (28th JDS, Otsu, Shiga, 5/9-11,1985) 84. Hatao,K., Matsuda,M., Tsuchiya,M., Miura,Y., Kaku,K. and Kaneko,T.: Regulation of liver F-2,6-P2 levels by sulfonylureas (relation to its hypoglycemic effect) Journal of Japan Diabetes Society 28:444, 1985. (28th JDS, Otsu, Shiga, 85. Matsuda,M., Sato,H., Nishida,J., Hirai,H., Kitamura,H., Ozawa,T., Kimura,R., Sato,N., Urabe,M. and Takaku,F.: A Case of Malignant lymphoma: Remarkable effect of L-Asparaginase. Japanese Clinical Hematology 24:297-298,1983. (79th RINKETU Reikai, Tokyo 11/27,1983)

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