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Forschungsprofil Martin Herrmann
1. LEBENSLAUF UND WISSENSCHAFTLICHER WERDEGANG
Prof. Dr. rer. nat. Dr. med. habil.
Martin Herrmann
Außerplanmäßiger
Professor
Institut für Klinische Immunologie und Rheumatologie Friedrich-Alexander-Universität Erlangen-Nürnberg WISSENSCHAFTLICHER WERDEGANG
Universitätsausbildung:
Studium der Chemie, Julius-Maximilians-Universität Würzburg Zivildienst in der Medizinischen Klinik I der Friedrich-Alexander Studium der Chemie an der der Friedrich-Alexander Universität Studium der Biologie an der der Friedrich-Alexander Universität Erlangen-Nürnberg (Diplom, Note „sehr gut“) Diplomarbeit am Institut für Klinische Immunologie und Rheumatologie der der Friedrich-Alexander Universität Erlangen- (Mentoren: Prof. E. Schweizer, Prof. J.R. Kalden) Beruflicher Werdegang:
Doktorand (Mentoren: Prof. E. Schweizer, Prof. J.R. Kalden), Friedrich-Alexander Universität Erlangen-Nürnberg Wissenschaftlicher Angestellter am Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander Universität Erlangen- Post-Doktorand und Habilitationsarbeit am Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander Universität Studienaufenthalt an der Universität von Alabama in Birmingham, Privatdozent am Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander Universität Erlangen-Nürnberg Außerplanmäßiger Professor am Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander Universität Erlangen-
Publikationsverzeichnis
Reviews
1. Munoz, L.E., Peter, C., Herrmann, M., Wesselborg, S., and Lauber, K., Scent of dying cells: The role of attraction signals in the clearance of apoptotic cells and its immunological consequences. Autoimmunity Reviews, 2010. 9(6): p. 425-430. 2. Munoz, L.E., Lauber, K., Schiller, M., Manfredi, A.A., Schett, G., Voll, R.E., and Herrmann, M., The role of incomplete clearance of apoptotic cells in the etiology and pathogenesis of SLE. Zeitschrift Fur Rheumatologie, 2010. 69(2): p. 152-+. 3. Munoz, L.E., Lauber, K., Schiller, M., Manfredi, A.A., and Herrmann, M., The role of defective clearance of apoptotic cells in systemic autoimmunity. Nature Reviews Rheumatology, 2010. 6(5): p. 280-289. 4. Herrmann, M., Constant dripping wears away the stone. Autoimmunity, 2009. 5. Chaurio, R.A., Janko, C., Munoz, L.E., Frey, B., Herrmann, M., and Gaipl, U.S., Phospholipids: Key Players in Apoptosis and Immune Regulation. Molecules, 2009. 14(12): p. 4892-4914. 6. Voll, R.E., Urbonaviciute, V., Herrmann, M., and Kalden, J.R., High mobility group box 1 in the pathogenesis of inflammatory and autoimmune diseases. Israel Medical Association Journal, 2008. 10(1): p. 26-28. 7. Voll, R.E., Urbonaviciute, V., Furnrohr, B., Herrmann, M., and Kalden, J.R., The role of high-mobility group box 1 protein in the pathogenesis of autoimmune diseases. Curr Rheumatol Rep, 2008. 10(5): p. 341-2. 8. Schulze, C., Munoz, L.E., Franz, S., Sarter, K., Chaurio, R.A., Gaipl, U.S., and Herrmann, M., Clearance deficiency-A potential link between infections and autoimmunity. Autoimmunity Reviews, 2008. 8(1): p. 5-8. 9. Sarter, K., Schulze, C., Voll, R.E., and Herrmann, M., Role of apoptosis failure in etiopathogenesis of systemic lupus erythematosus and murine lupus. Expert Review of Clinical Immunology, 2008. 4(1): p. 33-42. 10. Munoz, L.E., van Bavel, C., Franz, S., Berden, J., Herrmann, M., and van der Vlag, J., Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus, 2008. 17(5): p. 371-375. 11. Munoz, L.E., Gaipl, U.S., and Herrmann, M., Predictive value of anti-dsDNA autoantibodies: Importance of the assay. Autoimmunity Reviews, 2008. 7(8): p. 594-597. 12. Janko, C., Schorn, C., Grossmayer, G.E., Frey, B., Herrmann, M., Gaipl, U.S., and Munoz, L.E., Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE). Autoimmunity Reviews, 2008. 8(1): p. 9-12. 13. Frey, B., Janko, C., Ebel, N., Meister, S., Schluecker, E., Meyer-Pittroff, R., Fietkau, R., Herrmann, M., and Gaipl, U.S., Cells Under Pressure - Treatment of Eukaryotic Cells with High Hydrostatic Pressure, from Physiologic Aspects to Pressure Induced Cell Death. Current Medicinal Chemistry, 2008. 15(23): p. 2329-2336. 14. Winkler, T.H., Herrmann, M., Kalden, J.R., and Wellmann, U., The origin of pathogenic autoantibodies in SLE. Zeitschrift Fur Rheumatologie, 2007. 66: p. 37-37. 15. Urbonaviciute, V., Fuernrohr, B.G., Weber, C., Haslbeck, M., Wilhelm, S., Herrmann, M., and Voll, R.E., Factors masking HMGB1 in human serum and plasma. Journal of Leukocyte Biology, 2007. 81(1): p. 67-74. 16. Munoz, L.E., Frey, B., Pausch, F., Baum, W., Mueller, R.B., Brachvogel, B., Poschl, E., Roedel, F., von der Mark, K., Herrmann, M., and Gaipl, U.S., The role of annexin A5 in the modulation of the immune response against dying and dead cells. Current Medicinal Chemistry, 2007. 14(3): p. 271-277. 17. Horner, H., Frank, C., Dechant, C., Repp, R., Glennie, M., Herrmann, M., and Stockmeyer, B., Intimate cell conjugate formation and exchange of membrane lipids precede apoptosis induction in target cells during antibody-dependent, granulocyte-mediated cytotoxicity. Journal of Immunology, 2007. 179(1): p. 337-345. 18. Frey, B., Janko, C., Sarter, K., Schulze, C., Franz, S., Munoz, L.E., Gaipl, U.S., and Herrmann, M., Apoptosis, necrosis and autoantibodies. Zeitschrift Fur Rheumatologie, 2007. 66: p. 99-99. 19. Brunner, J., Gaipl, U., Munoz, L., Voll, R., Kalden, J., Wiesenhutter, C., Herrmann, M., and Kern, P.M., The low throughput protein a adsorber: An immune modulatory device for the treatment of rheumatoid arthritis. Aktuelle Rheumatologie, 2007. 32(5): p. 262-265. 20. Lorenz, H.M., Herrmann, M., Winkler, T., and Kaden, J.R., Pathogenesis of Systemic Lupus Erythematosus. Aktuelle Rheumatologie, 2006. 31(1): p. 48-55. 21. Gaipl, U.S., Sheriff, A., Franz, S., Munoz, L.E., Voll, R.E., Kalden, J.R., and Herrmann, M., Inefficient clearance of dying cells and autoreactivity. Curr Top Microbiol Immunol, 2006. 305: p. 161-76. 22. Gaipl, U.S., Kuhn, A., Sheriff, A., Munoz, L.E., Franz, S., Voll, R.E., Kalden, J.R., and Herrmann, M., Clearance of apoptotic cells in human SLE. Curr Dir Autoimmun, 2006. 9: p. 173-87. 23. Franz, S., Gaipl, U.S., Munoz, L.E., Sheriff, A., Beer, A., Kalden, J.R., and Herrmann, M., Apoptosis and autoimmunity: when apoptotic cells break their silence. Curr Rheumatol Rep, 2006. 8(4): p. 245-7. 24. Schiller, M., Blank, N., Heyder, P., Herrmann, M., Gaipl, U.S., Kalden, J.R., and Lorenz, H.M., Induction of apoptosis by spermine-metabolites in primary human blood cells and various tumor cell lines. Apoptosis, 2005. 10(5): p. 1151-1162. 25. Munoz, L.E., Herrmann, M., and Gaipl, U.S., An impaired clearance of dying cells can lead to the development of chronic autoimmunity. Zeitschrift Fur Rheumatologie, 2005. 64(6): p. 370-376. 26. Munoz, L.E., Gaipl, U.S., Franz, S., Sheriff, A., Voll, R.E., Kalden, J.R., and Herrmann, M., SLE - a disease of clearance deficiency? Rheumatology, 2005. 44(9): p. 1101-1107. 27. Herrmann, M., Gaipl, U.S., Franz, S., Stach, C.M., Munoz, L., Sheriff, A., Voll, R.E., and Kaiden, J.R., Defective clearance of dying cells fosters the development of SLE. Annals of the Rheumatic Diseases, 2005. 64: p. 53-53. 28. Grossmayer, G.E., Munoz, L.E., Gaipl, U.S., Franz, S., Sheriff, A., Voll, R.E., Kalden, J.R., and Herrmann, M., Removal of dying cells and systemic lupus erythematosus. Mod Rheumatol, 2005. 15(6): p. 383-90. 29. Gaipl, U.S., Voll, R.E., Sheriff, A., Franz, S., Kalden, J.R., and Herrmann, M., Impaired clearance of dying cells in systemic lupus erythematosus. Autoimmunity Reviews, 2005. 4(4): p. 189-194. 30. Brunner, J., Kern, P.M., Gaipl, U.S., Munoz, L.E., Voll, R.E., Kalden, J.R., Wiesenhutter, C.W., and Herrmann, M., The low-throughput protein A adsorber: an immune modulatory device. Hypothesis for the mechanism of action in the treatment of rheumatoid arthritis. Mod Rheumatol, 2005. 15(1): p. 9-18. 31. Sheriff, A., Gaipl, U.S., Voll, R.E., Kalden, J.R., and Herrmann, M., Apoptosis and systemic lupus erythematosus. Rheumatic Disease Clinics of North America, 2004. 30(3): p. 505-+. 32. Gaipl, U.S., Franz, S., Voll, R.E., Sheriff, A., Kalden, J.R., and Herrmann, M., Defects in the disposal of dying cells lead to autoimmunity. Curr Rheumatol Rep, 2004. 6(6): p. 401-7. 33. Kuenkele, S., Beyer, T.D., Voll, R.E., Kalden, J.R., and Herrmann, M., Impaired clearance of apoptotic cells in systemic lupus erythematosus: challenge of T and B cell tolerance. Curr Rheumatol Rep, 2003. 5(3): p. 175-7. 34. Gaipl, U.S., Brunner, J., Beyer, T.D., Voll, R.E., Kalden, J.R., and Herrmann, M., Disposal of dying cells: A balancing act, between infection and autoimmunity. Arthritis and Rheumatism, 2003. 48(1): p. 6-11. 35. Gaipl, U.S., Beyer, T.D., Voll, R.E., Franz, S., Kalden, J.R., and Herrmann, M., New aspects of the etiopathogenesis of systemic lupus erythematosus. Arthritis Research & Therapy, 2003. 5: p. S48-S48. 36. Gaipl, U.S., Beyer, T.D., Baumann, I., Voll, R.E., Stach, C.M., Heyder, P., Kalden, J.R., Manfredi, A., and Herrmann, M., Exposure of anionic phospholipids serves as anti-inflammatory and immunosuppressive signal - implications for antiphospholipid syndrome and systemic lupus erythematosus. Immunobiology, 2003. 207(1): p. 73-81. 37. Lorenz, H.M., Herrmann, M., and Kalden, J.R., The pathogenesis of autoimmune diseases. Scandinavian Journal of Clinical & Laboratory Investigation, 2001. 61: p. 16-26. 38. Beyer, T., Herrmann, M., Reiser, C., Bertling, W., and Hess, J., Bacterial carriers and virus-like-particles as antigen delivery devices: Role of dendritic cells in antigen presentation. Current Drug Targets - Infectious Disorders, 2001. 1(3): p. 287-302. 39. Lorenz, H.M., Herrmann, M., Winkler, T., Gaipl, U., and Kalden, J.R., Role of apoptosis in autoimmunity. Apoptosis, 2000. 5(5): p. 443-449. 40. Kalden, J.R., Voll, R.E., and Herrmann, M., The role of apoptosis in the pathogenesis of systemic lupus erythematosus. Immunology Letters, 2000. 73(2-3): p. 77. 41. Herrmann, M., Winkler, T., Gaipl, U., Lorenz, H.M., Geiler, T., and Kalden, J.R., Etiopathogenesis of systemic lupus erythematosus. International Archives of Allergy and Immunology, 2000. 123(1): p. 28-35. 42. Herrmann, M., Voll, R.E., Kolowos, W., Lorenz, H.M., and Kalden, J.R., Etiopathogenesis of systemic lupus erythematosus (SLE). Immunologist, 2000. 8(3): p. 66-71. 43. Herrmann, M., Voll, R.E., and Kalden, J.R., Etiopathogenesis of systemic lupus erythematosus. Immunology Today, 2000. 21(9): p. 424-426. 44. Kalden, J.R., Geiler, T., Herrmann, M., and Bertling, W., Gene therapy for RA: an already feasible treatment principle? Zeitschrift Fur Rheumatologie, 1998. 57(3): p. 139-146. 45. Herrmann, M., Neidhart, M., Gay, S., Hagenhofer, M., and Kalden, J.R., Retrovirus-associated rheumatic syndromes. Current Opinion in Rheumatology, 1998. 10(4): p. 347-354. 46. Herrmann, M., Zoller, O.M., Hagenhofer, M., Voll, R., and Kalden, J.R., What triggers anti-dsDNA antibodies? Molecular Biology Reports, 1996. 23(3-4): p. 265-267. 47. Herrmann, M. and Kalden, J.R., Retroviral antibodies. Autoantibodies, ed. 48. Herrmann, M., Hagenhofer, M., and Kalden, J.R., Retroviruses and systemic lupus erythematosus. Immunological Reviews, 1996. 152: p. 145-156. 49. Kalden, J.R. and Herrmann, M., Autoimmune diseases in humans, e.g. autoimmune rheumatic diseases. Intervirology, 1993. 35(1-4): p. 176-185. 50. Kalden, J.R., Winkler, T.H., Herrmann, M., and Krapf, F., PATHOGENESIS OF SLE IMMUNOPATHOLOGY IN MAN. Rheumatology International, 1991. 11(3): p. 95-100. Original Publications
1. Schorn, C., Strysio, M., Janko, C., Munoz, L.E., Schett, G., and Herrmann, M., The uptake by blood-borne phagocytes of monosodium urate is dependent on heat-labile serum factor(s) and divalent cations. Autoimmunity, 2010. 43(3): p. 236-238. 2. Munoz, L.E., Janko, C., Chaurio, R.A., Schett, G., Gaipl, U.S., and Herrmann, M., IgG opsonized nuclear remnants from dead cells cause systemic inflammation in SLE. Autoimmunity, 2010. 43(3): p. 232-235. 3. Hakkim, A., Fuernrohr, B.G., Amann, K., Laube, B., Abu Abed, U., Brinkmann, V., Herrmann, M., Voll, R.E., and Zychlinsky, A., Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proceedings of the National Academy of Sciences of the United States of America, 2010. 107(21): p. 9813-9818. Urbonaviciute, V., Meister, S., Fuernrohr, B.G., Frey, B., Gueckel, E., Schett, G., Herrmann, M., and Voll, R.E., Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis. Autoimmunity, 2009. 42(4): p. 305-307. 5. Stadler, K., Frey, B., Munoz, L.E., Finzel, S., Rech, J., Fietkau, R., Herrmann, M., Hueber, A., and Gaipl, U.S., Photopheresis with UV-A light and 8-methoxypsoralen leads to cell death and to release of blebs with anti-inflammatory phenotype in activated and non-activated lymphocytes. Biochemical and Biophysical Research Communications, 2009. 386(1): p. 71-76. 6. Schorn, C., Janko, C., Munoz, L., Schulze, C., Strysio, M., Schett, G., and Herrmann, M., Sodium and potassium urate crystals differ in their inflammatory potential. Autoimmunity, 2009. 42(4): p. 314-316. 7. Sarter, K., Andre, S., Kaltner, H., Lensch, M., Schulze, C., Urbonaviciute, V., Schett, G., Herrmann, M., and Gabius, H.-J., Detection and chromatographic removal of lipopolysaccharide in preparations of multifunctional galectins. Biochemical and Biophysical Research Communications, 2009. 379(1): p. 155-159. 8. Roedel, F., Keilholz, L., Herrmann, M., Weiss, C., Frey, B., Voll, R., Gaipl, U., and Roedel, C., Activator protein 1 shows a biphasic induction and transcriptional activity after low dose X-irradiation in EA.hy.926 endothelial cells. Autoimmunity, 2009. 42(4): p. 343-345. 9. Raaz, D., Herrmann, M., Ekici, A.B., Klinghammer, L., Lausen, B., Voll, R.E., Leusen, J.H.W., de Winkel, J.G.J.v., Daniel, W.G., Reis, A., and Garlichs, C.D., Fc gamma RIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease. Atherosclerosis, 2009. 205(2): p. 512-516. 10. Munoz, L.E., Janko, C., Grossmayer, G.E., Frey, B., Voll, R.E., Kern, P., Kalden, J.R., Schett, G., Fietkau, R., Herrmann, M., and Gaipl, U.S., Remnants of Secondarily Necrotic Cells Fuel Inflammation in Systemic Lupus Erythematosus. Arthritis and Rheumatism, 2009. 60(6): p. 1733-1742. 11. Manea, M.E., Mueller, R.B., Dejica, D., Sheriff, A., Schett, G., Herrmann, M., and Kern, P., Increased expression of CD154 and FAS in SLE patients' lymphocytes. Rheumatology International, 2009. 30(2): p. 181-185. 12. Maier, J.M., Spitzer, P., Klafki, H.-W., Esselmann, H., Lewczuk, P., Kornhuber, J., Herrmann, M., and Wiltfang, J., Distinct fractional A beta release patterns in human mononuclear phagocytes. Journal of Neuroimmunology, 2009. 206(1-2): p. 1-4. 13. Gaipl, U.S., Meister, S., Loedermann, B., Roedel, F., Fietkau, R., Herrmann, M., Kern, P.M., and Frey, B., Activation-induced cell death and total Akt content of granulocytes show a biphasic course after low-dose radiation. Autoimmunity, 2009. 42(4): p. 340-342. 14. Frey, B., Schildkopf, P., Roedel, F., Weiss, E.M., Munoz, L.E., Herrmann, M., Fietkau, R., and Gaipl, U.S., AnnexinA5 renders dead tumor cells immunogenic-implications for multimodal cancer therapies. Journal of Immunotoxicology, 2009. 6(4): p. 209-216. 15. Frey, B., Munoz, L.E., Pausch, F., Sieber, R., Franz, S., Brachvogel, B., Poschl, E., Schneider, H., Roedel, F., Sauer, R., Fietkau, R., Herrmann, M., and Gaipl, U.S., The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype. Journal of Cellular and Molecular Medicine, 2009. 13(7): p. 1391-1399. 16. Frey, B., Gaipl, U.S., Sarter, K., Zaiss, M.M., Stillkrieg, W., Roedel, F., Schett, G., Herrmann, M., Fietkau, R., and Keilholz, L., Whole body low dose irradiation improves the course of beginning polyarthritis in human TNF-transgenic mice. Autoimmunity, 2009. 42(4): p. 346-348. 17. Di Comite, G., Rossi, C.M., Marinosci, A., Lolmede, K., Baldissera, E., Aiello, P., Mueller, R.B., Herrmann, M., Voll, R.E., Rovere-Querini, P., Sabbadini, M.G., Corti, A., and Manfredi, A.A., Circulating chromogranin A reveals extra-articular involvement in patients with rheumatoid arthritis and curbs TNF-alpha-elicited endothelial activation. Journal of Leukocyte Biology, 2009. 85(1): p. 81-87. 18. Blume, K.E., Soeroes, S., Waibel, M., Keppeler, H., Wesselborg, S., Herrmann, M., Schulze-Osthoff, K., and Lauber, K., Cell Surface Externalization of Annexin A1 as a Failsafe Mechanism Preventing Inflammatory Responses during Secondary Necrosis. Journal of Immunology, 2009. 183(12): p. 8138-8147. 19. Appel, H., Ruiz-Heiland, G., Listing, J., Zwerina, J., Herrmann, M., Mueller, R., Haibel, H., Baraliakos, X., Hempfing, A., Rudwaleit, M., Sieper, J., and Schett, G., Altered Skeletal Expression of Sclerostin and Its Link to Radiographic Progression in Ankylosing Spondylitis. Arthritis and Rheumatism, 2009. 60(11): p. 3257-3262. 20. Urbonaviciute, V., Fuernrohr, B.G., Meister, S., Munoz, L., Heyder, P., De Marchis, F., Bianchi, M.E., Kirschning, C., Wagner, H., Manfredi, A.A., Kalden, J.R., Schett, G., Rovere-Querini, P., Herrmann, M., and Voll, R.E., Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. Journal of Experimental Medicine, 2008. 205(13): p. 3007-3018. 21. Schiller, M., Franz, S., Heyder, P., Voll, R.E., Gaipl, U.S., Lorenz, H.-M., Kalden, J.R., and Herrmann, M., Hypothesis: human serum-borne albumin bound lipids promote cellular survival after apoptosis induction by a variety of stimuli. Apoptosis, 2008. 13(2): p. 319-328. 22. Maseda, D., Meister, S., Neubert, K., Herrmann, M., and Voll, R.E., Proteasome inhibition drastically but reversibly impairs murine lymphocyte development. Cell Death and Differentiation, 2008. 15(3): p. 600-612. 23. Maler, J.M., Spitzer, P., Klafki, H.-W., Esselmann, H., Bibl, M., Lewczuk, P., Kornhuber, J., Herrmann, M., and Wiltfang, J., Adherence-dependent shifts in the patterns of beta-amyloid peptides secreted by human mononuclear phagocytes. Brain Behavior and Immunity, 2008. 22(7): p. 1044-1048. 24. Grossmayer, G.E., Munoz, L.E., Weber, C.K., Franz, S., Voll, R.E., Kern, P.M., Kalden, J.R., Schett, G., Herrmann, M., and Gaipl, U.S., IgG autoantibodies bound to surfaces of necrotic cells and complement C4 comprise the phagocytosis promoting activity for necrotic cells of systemic lupus erythaematosus sera. Annals of the Rheumatic Diseases, 2008. 67(11): p. 1626-1632. 25. Beer, A., Andre, S., Kaltner, H., Lensch, M., Franz, S., Sarter, K., Schulze, C., Gaipl, U.S., Kern, P., Herrmann, M., and Gabius, H.-J., Human galectins as sensors for apoptosis/necrosis-associated surface changes of granulocytes and lymphocytes. Cytometry Part A, 2008. 73A(2): p. 139-147. 26. Axmann, R., Herman, S., Zaiss, M., Franz, S., Polzer, K., Zwerina, J., Herrmann, M., Smolen, J., and Schett, G., CTLA-4 directly inhibits osteoclast formation. Annals of the Rheumatic Diseases, 2008. 67(11): p. 1603-1609. 27. Arnold, M., Gaipl, U., Brunner, J., Spriewald, B., Herrmann, M., and Haas, J.P., The expanded double negative T cell populations of a patient with ALPS are not clonally related to CD4+ or to CD8+ T cells (vol 40, pg 299, 2007). Autoimmunity, 2008. 41(3): p. 239-240. 28. Roedel, F., Keilholz, L., Herrmann, M., Sauer, R., and Hildebrandt, G., Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy. International Journal of Radiation Biology, 2007. 83(6): p. 357-366. 29. Munoz, L.E., Franz, S., Pausch, F., Fuernrohr, B., Sheriff, A., Vogt, B., Kern, P.M., Baum, W., Stach, C., von Laer, D., Brachvogel, B., Poschl, E., Herrmann, M., and Gaipl, U.S., The influence on the immunomodulatory effects of dying and dead cells of Annexin V. Journal of Leukocyte Biology, 2007. 81(1): p. 6-14. 30. Meister, S., Schubert, U., Neubert, K., Herrmann, K., Burger, R., Gramatzki, M., Hahn, S., Schreiber, S., Wilhelm, S., Herrmann, M., Jaeck, H.-M., and Voll, R.E., Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Research, 2007. 67(4): p. 1783-1792. 31. Marlies, A., Udo, G., Juergen, B., Bernd, S., Herrmann, M., and Haas, J.P., The expanded double negative T cell populations of a patient with ALPS are not clonally related to CD41 or to CD81 T cells. Autoimmunity, 2007. 40(4): p. 299-301. 32. Maler, J.M., Spitzer, P., Lewczuk, P., Kornhuber, J., Herrmann, M., and Wiltfang, J., Decreases of hematopoietic stem cells in early Alzheimer's disease. Pharmacopsychiatry, 2007. 40(5): p. 233-234. 33. Horner, H., Frank, C., Dechant, C., Repp, R., Glennie, M., Herrmann, M., and Stockmeyer, B., Intimate cell conjugate formation and exchange of membrane lipids precede apoptosis induction in target cells during antibody-dependent, granulocyte-mediated cytotoxicity. Journal of Immunology, 2007. 179(1): p. 337-345. 34. Heyder, P., Bekeredjian-Ding, I., Parcina, M., Blank, N., Ho, A.D., Herrmann, M., Lorenz, H.-M., Heeg, K., and Schiller, M., Purified apoptotic bodies stimulate plasmacytoid dendritic cells to produce IFN-alpha. Autoimmunity, 2007. 40(4): p. 331-332. 35. Girkontaite, I., Urbonaviciute, V., Maseda, D., Neubert, K., Herrmann, M., and Voll, R.E., Apoptotic cells selectively suppress the Th1 cytokine interferon G in stimulated human peripheral blood mononuclear cells and shift the Th1/Th2 balance towards Th2. Autoimmunity, 2007. 40(4): p. 327-330. 36. Gaipl, U.S., Munoz, L.E., Grossmayer, G., Lauber, K., Franz, S., Sarter, K., Voll, R.E., Winkler, T., Kuhn, A., Kalden, J., Kern, P., and Herrmann, M., Clearance deficiency and systemic lupus erythematosus (SLE). Journal of Autoimmunity, 2007. 28(2-3): p. 114-121. 37. Fuernrohr, B.G., Groer, G.J., Sehnert, B., Herrmann, M., and Voll, R.E., Interaction of histones with phospholipids - implications for the exposure of histones on apoptotic cells. Autoimmunity, 2007. 40(4): p. 322-326. 38. Franz, S., Herrmann, K., Fuehrnrohr, B., Sheriff, A., Frey, B., Gaipl, U.S., Voll, R.E., Kalden, J.R., Jaeck, H.M., and Herrmann, M., After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes. Cell Death and Differentiation, 2007. 14(4): p. 733-742. 39. van Zandbergen, G., Bollinger, A., Wenzel, A., Kamhawi, S., Voll, R., Klinger, M., Mueller, A., Hoelscher, C., Herrmann, M., Sacks, D., Solbach, W., and Laskay, T., Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum. Proceedings of the National Academy of Sciences of the United States of America, 2006. 103(37): p. 13837-13842. 40. Maler, J.M., Spitzer, P., Lewczuk, P., Kornhuber, J., Herrmann, M., and Wiltfang, J., Decreased circulating CD34(+) stem cells in early Alzheimer's disease: evidence for a deficient hematopoietic brain support? Molecular Psychiatry, 2006. 11(12): p. 1113-1115. 41. Kuhn, A., Herrmann, M., Kleber, S., Beckmann-Welle, M., Fehsel, K., Martin- Villalba, A., Lehmann, P., Ruzicka, T., Krammer, P.H., and Kolb-Bachofen, V., Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis and Rheumatism, 2006. 54(3): p. 939-950. 42. Frey, B., Hartmann, M., Herrmann, M., Meyer-Pittroff, R., Sommer, K., and Bluemelhuber, G., Microscopy under pressure--an optical chamber system for fluorescence microscopic analysis of living cells under high hydrostatic pressure. Microsc Res Tech, 2006. 69(2): p. 65-72. 43. Franz, S., Frey, B., Sheriff, A., Gaipl, U.S., Beer, A., Voll, R.E., Kalden, J.R., and Herrmann, M., Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis. Cytometry Part A, 2006. 69A(4): p. 230-239. 44. Bottcher, A., Gaipl, U.S., Furnrohr, B.G., Herrmann, M., Girkontaite, I., Kalden, J.R., and Voll, R.E., Involvement of phosphatidylserine, alpha v beta 3, CD14, CD36, and complement C1q in the phagocytosis of primary necrotic lymphocytes by macrophages. Arthritis and Rheumatism, 2006. 54(3): p. 927-938. 45. Wellmann, U., Letz, M., Herrmann, M., Angermuller, S., Kalden, J.R., and Winkler, T.H., The evolution of human and-double-stranded DNA autoantibodies. Proceedings of the National Academy of Sciences of the United States of America, 2005. 102(26): p. 9258-9263. 46. Schlenk, J., Lorenz, H.M., Haas, J.P., Herrmann, M., Hohenberger, G., Kalden, J.R., Rollinghoff, M., and Beuscher, H.U., Extravasation into synovial tissue induces CCL20 mRNA expression in polymorphonuclear neutrophils of patients with rheumatoid arthritis. Journal of Rheumatology, 2005. 32(12): p. 2291-2298. 47. Schiller, M., Blank, N., Heyder, P., Herrmann, M., Gaipl, U.S., Kalden, J.R., and Lorenz, H.M., Induction of apoptosis by spermine-metabolites in primary human blood cells and various tumor cell lines. Apoptosis, 2005. 10(5): p. 1151-1162. 48. Rodel, F., Hoffmann, J., Distel, L., Herrmann, M., Noisternig, T., Papadopoulos, T., Sauer, R., and Rodel, C., Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Research, 2005. 65(11): p. 4881-4887. 49. Rodel, F., Franz, S., Sheriff, A., Gaipl, U., Heyder, P., Hildebrandt, G., Schultze- Mosgau, S., Voll, R.E., and Herrmann, M., The CFSE distribution assay is a powerful technique for the analysis of radiation-induced cell death and survival on a single-cell level. Strahlentherapie Und Onkologie, 2005. 181(7): p. 456-462. 50. Kolowos, K., Gaipl, U.S., Sheriff, A., Voll, R.E., Heyder, P., Kern, P., Kalden, J.R., and Herrmann, M., Microparticles shed from different antigen-presenting cells display an individual pattern of surface molecules and a distinct potential of allogeneic T-cell activation. Scandinavian Journal of Immunology, 2005. 61(3): p. 226-233. 51. Knott, A., Drueppel, L., Beyer, T., Garke, K., Berens, C., Herrmann, M., and Hillen, W., An optimized conditional suicide switch using doxycycline-dependent expression of human tBid. Cancer Biology & Therapy, 2005. 4(5): p. 532-536. 52. Dumitriu, I.E., Baruah, P., Valentinis, B., Voll, R.E., Herrmann, M., Nawroth, P.P., Arnold, B., Bianchi, M.E., Manfredi, A.A., and Rovere-Querini, P., Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. Journal of Immunology, 2005. 174(12): p. 7506-7515. 53. Brunner, J.K.H., Herrmann, M., Metzler, M., Gaipl, U., and Haas, P., The T-cell repertoire in peripheral blood and synovial fluid in patients with juvenile idiopathic arthritis shows a clonotypic archetype. Annals of the Rheumatic Diseases, 2005. 64: p. 127-128. 54. Brinkman, M., Walter, J., Grein, S., Thies, M.J.W., Schulz, T.W., Herrmann, M., Reiser, C.O.A., and Hess, J., Beneficial therapeutic effects with different particulate structures of murine polyomavirus VP1-coat protein carrying self or non-self CD8 T cell epitopes against murine melanoma. Cancer Immunology Immunotherapy, 2005. 54(6): p. 611-622. 55. Appelt, U., Sheriff, A., Gaipl, U.S., Kalden, J.R., Voll, R.E., and Herrmann, M., Viable, apoptotic and necrotic monocytes expose phosphatidylserine: cooperative binding of the ligand Annexin V to dying but not viable cells and implications for PS-dependent clearance. Cell Death and Differentiation, 2005. 12(2): p. 194-196. 56. Sheriff, A., Gaipl, U.S., Franz, S., Heyder, P., Voll, R.E., Kalden, J.R., and Herrmann, M., Loss of GM1 surface expression precedes annexin V-phycoerythrin binding of neutrophils undergoing spontaneous apoptosis during in vitro aging. Cytometry Part A, 2004. 62A(2): p. 75-80. 57. Rodel, F., Schaller, U., Schultze-Mosgau, S., Beuscher, H.U., Keilholz, L., Herrmann, M., Voll, R., Sauer, R., and Hildebrandt, G., The induction of TGF-beta(1) and NF-kappa B parallels a biphasic time course of leukocyte/endothelial cell adhesion following low-dose X-irradiation. Strahlentherapie Und Onkologie, 2004. 180(4): p. 194-200. 58. Rodel, F., Hantschel, M., Hildebrandt, G., Schultze-Mosgau, S., Rodel, C., Herrmann, M., Sauer, R., and Voll, R.E., Dose-dependent biphasic induction and transcriptional activity of nuclear factor kappa B (NF-kappa B) in EA.hy.926 endothelial cells after low-dose X-irradiation. International Journal of Radiation Biology, 2004. 80(2): p. 115-123. 59. Korn, A., Frey, B., Shereff, A., Gawl, U.S., Franz, S., Meyer-Pittroff, R., Herrmann, M., and Bluemelhuber, G., High hydrostatic pressure inactivated human tumour cells preserve their immunogenicity. Cellular and Molecular Biology, 2004. 50(4): p. 469-477. 60. Gaipl, U.S., Beyer, T.D., Heyder, P., Kuenkele, S., Bottcher, A., Voll, R.E., Kalden, J.R., and Herrmann, M., Cooperation between C1q and DNase I in the clearance of necrotic cell-derived chromatin. Arthritis and Rheumatism, 2004. 50(2): p. 640-649. 61. Frey, B., Franz, S., Sheriff, A., Korn, A., Bluemelhuber, G., Gaipl, U.S., Voll, R.E., Meyer-Pittroff, R., and Herrmann, M., Hydrostatic pressure induced death of mammalian cells engages pathways related to apoptosis or necrosis. Cellular and Molecular Biology, 2004. 50(4): p. 459-467. 62. Dumitriu, I.E., Voll, R.E., Kolowos, W., Gaipl, U.S., Heyder, P., Kalden, J.R., and Herrmann, M., UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase. Cell Death and Differentiation, 2004. 11(3): p. 314-320. 63. Bondanza, A., Zimmermann, V.S., Rovere-Querini, P., Turnay, J., Dumitriu, I.E., Stach, C.M., Voll, R.E., Gaipl, U.S., Bertling, W., Poschl, E., Kalden, J.R., Manfredi, A.A., and Herrmann, M., Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo. Journal of Experimental Medicine, 2004. 200(9): p. 1157-1165. 64. Stockmeyer, B., Beyer, T., Neuhuber, W., Repp, R., Kalden, J.R., Valerius, T., and Herrmann, M., Polymorphonuclear granulocytes induce antibody-dependent apoptosis in human breast cancer cells. Journal of Immunology, 2003. 171(10): p. 5124-5129. 65. Heyder, P., Gaipl, U.S., Beyer, T.D., Voll, R.E., Kern, P.M., Stach, C., Kalden, J.R., and Herrmann, M., Early detection of apoptosis by staining of acid-treated apoptotic cells with FITC-labeled lectin from Narcissus pseudonarcissus. Cytometry Part A, 2003. 55A(2): p. 86-93. 66. Gaipl, U.S., Beyer, T.D., Baumann, I., Voll, R.E., Stach, C.M., Heyder, P., Kalden, J.R., Manfredi, A., and Herrmann, M., Exposure of anionic phospholipids serves as anti-inflammatory and immunosuppressive signal - implications for antiphospholipid syndrome and systemic lupus erythematosus. 67. Dumitriu, I.E., Roedel, F., Beyer, T.D., Gaipl, U.S., Kalden, J.R., and Herrmann, M., UV or X-irradiation increases the cytoplasmic accumulation of rhodamine 123 in various cancer cell lines. Strahlentherapie Und Onkologie, 2003. 179(8): p. 564-570. 68. Roedel, F., Kley, N., Beuscher, H.U., Hildebrandt, G., Keilholz, L., Kern, P., Voll, R., Herrmann, M., and Sauer, R., Anti-inflammatory effect of low-dose X-irradiation and the involvement of a TGF-beta(1)-induced down-regulation of leukocyte/endothelial cell adhesion. International Journal of Radiation Biology, 2002. 78(8): p. 711-719. 69. Dimitrova, P., Skapenko, A., Herrmann, M.L., Schleyerbach, R., Kalden, J.R., and Schulze-Koops, H., Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation. Journal of Immunology, 2002. 169(6): p. 3392-3399. 70. Blank, N., Burger, R., Duerr, B., Bakker, F., Wohlfarth, A., Dumitriu, I., Kalden, J.R., and Herrmann, M., MEK inhibitor U0126 interferes with immunofluorescence analysis of apoptotic cell death. Cytometry, 2002. 48(4): p. 179-184. 71. Beyer, T.D., Kolowos, W., Dumitriu, I.E., Voll, R.E., Heyder, P., Gaipl, U.S., Kalden, J.R., and Herrmann, M., Apoptosis of the teratocarcinoma cell line tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B. Scandinavian Journal of Immunology, 2002. 56(3): p. 303-309. 72. Baumann, I., Kolowos, W., Voll, R.E., Manger, B., Gaipl, U., Neuhuber, W.L., Kirchner, T., Kalden, J.R., and Herrmann, M., Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis and Rheumatism, 2002. 46(1): p. 191-201. 73. Schroppel, K., Kryk, M., Herrmann, M., Leberer, E., Rollinghoff, M., and Bogdan, C., Suppression of type 2 NO-synthase activity in macrophages by Candida albicans. International Journal of Medical Microbiology, 2001. 290(8): p. 659-668. 74. Kolowos, W., Gaipl, U.S., Voll, R.E., Frank, C., Haas, J.P., Beyer, T.D., Kalden, J.R., and Herrmann, M., CD4 positive peripheral T cells from patients with systemic lupus erythematosus (SLE) are clonally expanded. Lupus, 2001. 10(5): p. 321-331. 75. Kern, P.M., Keilholz, L., Kalden, J.R., and Herrmann, M., Apoptotic UV- irradiated lymphocytes undergo protease mediated shedding of L-selectin in vitro. Transfusion and Apheresis Science, 2001. 24(1): p. 99-101. 76. Garlichs, C.D., Eskafi, S., Raaz, D., Schmidt, A., Ludwig, J., Herrmann, M., Klinghammer, L., Daniel, W.G., and Schmeisser, A., Patients with acute coronary syndromes express enhanced CD40 ligand/CD154 on platelets. Heart (London), 2001. 86(6): p. 649-655. 77. Gaipl, U.S., Kuenkele, S., Voll, R.E., Beyer, T.D., Kolowos, W., Heyder, P., Kalden, J.R., and Herrmann, M., Complement binding is an early feature of necrotic and a rather late event during apoptotic cell death. Cell Death and Differentiation, 2001. 8(4): p. 327-334. 78. Dumitriu, I.E., Mohr, W.G., Kolowos, W., Kern, P., Kalden, J.R., and Herrmann, M., 5,6-carboxyfluorescein diacetate succinimidyl ester-labeled apoptotic and necrotic as well as detergent-treated cells can be traced in composite cell samples. Analytical Biochemistry, 2001. 299(2): p. 247-252. 79. Beyer, T., Herrmann, M., Reiser, C., Bertling, W., and Hess, J., Bacterial carriers and virus-like-particles as antigen delivery devices: Role of dendritic cells in antigen presentation. Current Drug Targets - Infectious Disorders, 2001. 1(3): p. 287-302. 80. Stach, C.M., Turnay, X., Voll, R.E., Kern, P.M., Kolowos, W., Beyer, T.D., Kalden, J.R., and Herrmann, M., Treatment with annexin V increases immunogenicity of apoptotic human T-cells in Balb/c mice. Cell Death and Differentiation, 2000. 7(10): p. 911-915. 81. Kern, P.M., Keilholz, L., Forster, C., Stach, C., Beyer, T.D., Gaipl, U.S., Kalden, J.R., Hallmann, R., and Herrmann, M., UVB-irradiated T-cells undergoing apoptosis lose L-selectin by metalloprotease-mediated shedding. International Journal of Radiation Biology, 2000. 76(9): p. 1265-1271. 82. Kern, P.M., Keilholz, L., Forster, C., Hallmann, R., Herrmann, M., and Seegenschmiedt, M.-H., Low-dose radiotherapy selectively reduces adhesion of peripheral blood mononuclear cells to endothelium in vitro. Radiotherapy and Oncology, 2000. 54(3): p. 273-282. 83. Kern, P.M., Herrmann, M., Stockmeyer, B., Kalden, J.R., Valerius, T., and Repp, R., Flow cytometric discrimination between viable neutrophils, apoptotic neutrophils and eosinophils by double labelling of permeabilized blood granulocytes. Journal of Immunological Methods, 2000. 241(1-2): p. 11-18. 84. Huss, R., Haas, C., Herrmann, M., Kalden, J.R., and Lohrs, U., Impairment of genomic DNA binding to a putative dysfunctional receptor on erythrocytes independent of complement and antibodies in systemic lupus erythematosus. Virchows Archiv, 2000. 437(4): p. 380-387. 85. Frank, C., Herrmann, M., Fernandez, S., Dirnecker, D., Boswald, M., Kolowos, W., Ruder, H., and Haas, J.P., Dominant T cells in idiopathic nephrotic syndrome of childhood. Kidney International, 2000. 57(2): p. 510-517. 86. Burger, W., Hampel, C., Kaltenbach, M., Hartmann, A., Herrmann, M., Hoffmann, J.A., and Klepzig, H., Effect of atenolol and celiprolol on acetylcholine-induced coronary vasomotion in coronary artery disease. American Journal of Cardiology, 2000. 85(2): p. 172-177. 87. Kern, P., Kolowos, W., Hagenhofer, M., Frank, C., Kalden, J.R., and Herrmann, M., Alternatively spliced mRNA molecules of the thrombospondin receptor (CD36) in human PBMC. European Journal of Immunogenetics, 1999. 26(5): p. 337-342. 88. Kern, P., Keilholz, L., Forster, C., Seegenschmiedt, M.H., Sauer, R., and Herrmann, M., In vitro apoptosis in peripheral blood mononuclear cells induced by low-dose radiotherapy displays a discontinuous dose-dependence. International Journal of Radiation Biology, 1999. 75(8): p. 995-1003. 89. Hohenadl, C., Germaier, H., Walchner, M., Hagenhofer, M., Herrmann, M., Sturzl, M., Kind, P., Hehlmann, R., Erfle, V., and Leib-Mosch, C., Transcriptional activation of endogenous retroviral sequences in human epidermal keratinocytes by UVB irradiation. Journal of Investigative Dermatology, 1999. 90. Haas, J.P., Frank, C., Haefner, R., Herrmann, M., Spath, H., and Ruder, H., Inverted ratio of m-fas/s-fas expression in early onset pauciarticular juvenile chronic arthritis. European Journal of Immunogenetics, 1999. 26(5): p. 325-329. 91. Ponner, B.B., Stach, C., Zoller, O., Hagenhofer, M., Voll, R., Kalden, J.R., and Herrmann, M., Induction of apoptosis reduces immunogenicity of human T-cell lines in mice. Scandinavian Journal of Immunology, 1998. 47(4): p. 343-347. 92. Perniok, A., Wedekind, F., Herrmann, M., Specker, C., and Schneider, M., High levels of circulating early apoptotic peripheral blood mononuclear cells in systemic lupus erythematosus. Lupus, 1998. 7(2): p. 113-118. 93. Herrmann, M., Voll, R.E., Zoller, O.M., Hagenhofer, M., Ponner, B.B., and Kalden, J.R., Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis and Rheumatism, 1998. 41(7): p. 1241-1250. 94. Hagenhofer, M., Germaier, H., Hohenadl, C., Rohwer, P., Kalden, J.R., and Herrmann, M., UV-B irradiated cell lines execute programmed cell death in various forms. Apoptosis, 1998. 3(2): p. 123-132. 95. Haas, J.P., Grunke, M., Frank, C., Kolowos, W., Dirnecker, D., Leipold, G., Hieronymus, T., Lorenz, H.-M., and Herrmann, M., Increased spontaneous in vitro apoptosis in double negative T cells of humans with a fas/apo-1 mutation. Cell Death and Differentiation, 1998. 5(9): p. 751-757. 96. Voll, R.E., Roth, E.A., Girkontaite, I., Fehr, H., Herrmann, M., Lorenz, H.-M., and Kalden, J.R., Histone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production. Arthritis and Rheumatism, 1997. 40(12): p. 2162-2171. 97. Voll, R.E., Herrmann, M., Roth, E.A., Stach, C., Kalden, J.R., and Girkontaite, I., Immunosuppressive effects of apoptotic cells. Nature, 1997. 390(6658): p. 350-351. 98. Lorenz, H.M., Grunke, M., Hieronymus, T., Herrmann, M., Kuhnel, A., Manger, B., and Kalden, J.R., In vitro apoptosis and expression of apoptosis-related molecules in lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases. Arthritis and Rheumatism, 1997. 40(2): p. 306-317. 99. Kolowos, W., Herrmann, M., Ponner, B.B., Voll, R., Kern, P., Frank, C., and Kalden, J.R., Detection of restricted junctional diversity of peripheral T cells in SLE patients by spectratyping. Lupus, 1997. 6(9): p. 701-707. 100. Herrmann, M., Voll, R., Woith, W., Hagenhofer, M., Lorenz, H.M., Manger, B., and Kalden, J.R., Small DNA fragments isolated from human T-cell clones are enriched in sequences involved in DNA bending. Cell Death and Differentiation, 1996. 3(4): p. 391-395. 101. Herrmann, M., Winkler, T.H., Fehr, H., and Kalden, J.R., PREFERENTIAL RECOGNITION OF SPECIFIC DNA MOTIFS BY ANTI-DOUBLE-STRANDED DNA AUTOANTIBODIES. European Journal of Immunology, 1995. 25(7): p. 1897-1904. 102. Herrmann, M., Lorenz, H.M., Voll, R., Grunke, M., Woith, W., and Kalden, J.R., A RAPID AND SIMPLE METHOD FOR THE ISOLATION OF APOPTOTIC DNA FRAGMENTS. Nucleic Acids Research, 1994. 22(24): p. 5506-5507. 103. Herrmann, M. and Kalden, J.R., PCR AND REVERSE DOT HYBRIDIZATION FOR THE DETECTION OF ENDOGENOUS RETROVIRAL TRANSCRIPTS. Journal of Virological Methods, 1994. 46(3): p. 333-348. 104. Woith, W., Nusslein, I., Antoni, C., Dejica, D.I., Winkler, T.H., Herrmann, M., Pirner, K., Kalden, J.R., and Manger, B., A SOLUBLE FORM OF THE HUMAN TRANSFERRIN RECEPTOR IS RELEASED BY ACTIVATED LYMPHOCYTES INVITRO. Clinical and Experimental Immunology, 1993. 92(3): p. 537-542. 105. Herrmann, M., Baur, A., Nebelschickel, H., Vornhagen, R., Jahn, G., Krapf, F.E., and Kalden, J.R., ANTIBODIES AGAINST P24 OF HIV-1 IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS. Viral Immunology, 1992. 5(3): p. 229-231. 106. Voll, R., Aepinus, C., Krapf, F., Herrmann, M., Kalden, J.R., and Fleckenstein, B., MONOCLONAL-ANTIBODIES DIRECTED AGAINST THE REV PROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1. Molecular and Cellular Probes, 1990. 4(1): p. 63-72. 107. Krapf, F.E., Herrmann, M., Leitmann, W., Schwartlander, B., and Kalden, J.R., CIRCULATING IMMUNE COMPLEXES IN HIV-INFECTED PERSONS. Klinische Wochenschrift, 1990. 68(6): p. 299-305. Krapf, F.E., Herrmann, M., Leitmann, W., and Kalden, J.R., ARE RETROVIRUSES INVOLVED IN THE PATHOGENESIS OF SLE EVIDENCE DEMONSTRATED BY MOLECULAR ANALYSIS OF NUCLEIC ACIDS FROM SLE PATIENTS' PLASMA. Rheumatology International, 1989. 9(3-5): p. 115-122. 109. Krapf, F., Herrmann, M., Leitmann, W., and Kalden, J.R., ANTIBODY-BINDING OF MACROMOLECULAR DNA AND RNA IN THE PLASMA OF SLE PATIENTS. Clinical and Experimental Immunology, 1989. 75(3): p. 336-342. 110. Krapf, F., Herrmann, M., Leitmann, W., and Kalden, J.R., CIRCULATING IMMUNE-COMPLEXES IN DISEASE OF THE RHEUMATIC ENTITY. Medizinische Welt, 1989. 40(14-15): p. 454-458. 111. Huber, C., Ruger, A., Herrmann, M., Krapf, F., and Kalden, J.R., C3- CONTAINING SERUM IMMUNE-COMPLEXES IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - CORRELATION TO DISEASE-ACTIVITY AND COMPARISON WITH OTHER RHEUMATIC DISEASES. Rheumatology International, 1989. 9(2): p. 59-64. 112. Krapf, F., Fuchs, C., Herrmann, M., Hoferichter, S., and Kalden, J.R., DETERMINATION OF COMPLEMENT ACTIVATING CIRCULATING IMMUNE-COMPLEXES AND AN EXAMPLE FOR ANTIGEN SPECIFIC IMMUNE-COMPLEX ASSAYS. Journal of Clinical & Laboratory Immunology, 1986. 21(4): p. 183-187. Abstracts
1. Urbonaviciute, V., Fuernrohr, B.G., Meister, S., Munoz, L., Heyder, P., De Marchis, F., Bianchi, M.E., Kirschning, C., Wagner, H., Manfredi, A.A., Kalden, J.R., Schett, G., Rovere-Querini, P., Herrmann, M., and Voll, R.E., HMGB1 CONTAINING NUCLEOSOMES FROM APOPTOTIC CELLS INDUCE INFLAMMATION AND IMMUNE ACTIVATION VIA TLR2-IMPLICATIONS FOR THE ETIOPATHOGENESIS OF SYSTEMIC LUPUS ERYTHEMATOSUS. Annals of the Rheumatic Diseases, 2010. 69: p. A1-A1. 2. Mierke, C., Frey, B., Fellner, M., Herrmann, M., and Fabry, B., Integrin alpha 5 beta 1 facilitates cancer cell invasion through enhanced generation of contractile forces. European Journal of Cell Biology, 2010. 89: p. 16-16. 3. Loedermann, B., Gaipl, U.S., Weiss, E.M., Munoz, L.E., Herrmann, M., Keitholz, L., Roedel, F., Fietkau, R., and Frey, B., Low dose irradiation influences the inflammatory phenotype of activated macrophages in a discontinuous dose depended manner. Strahlentherapie Und Onkologie, 2010. 186: p. 42-43. 4. Frey, B., Weiss, E.M., Schildkopf, P., Roedel, F., Munoz, L., Herrmann, M., Fietkau, R., and Gaipl, U.S., AnnexinA5 as adjuvant in multimodal cancer therapies. Strahlentherapie Und Onkologie, 2010. 186: p. 68-68. 5. Mierke, C.T., Frey, B., Fellner, M., and Herrmann, M., Integrin alpha 5 beta 1- mediated increase in contractile force generation leads to enhanced tumor cell invasion, but decreased tumor growth. European Journal of Cell Biology, 2009. 88: p. 52-52. 6. Loedermann, B., Gaipl, U.S., Sieber, R., Herrmann, M., Fietkau, R., and Frey, B., Modulation of the NALP3 inflammasome in macrophages by low dose radiation. Strahlentherapie Und Onkologie, 2009. 185: p. 145-145. 7. Herrmann, M., Constant dripping wears away the stone. Autoimmunity, 2009. 8. Gaipl, U.S., Loedermann, B., Meister, S., Sieber, R., Fietkau, R., Roedel, F., Herrmann, M., and Frey, B., Low dose irradiation modulates activation induced cell death and total Akt content of granulocytes in a biphasic manner - implications for the clinical use of low dose radiation therapy. Strahlentherapie Und Onkologie, 2009. 185: p. 12-13. 9. Frey, B., Gaipl, U.S., Roedel, F., Herrmann, M., Fietkau, R., Sauer, R., and Keilholz, L., Low dose radiation therapy - local application leads to systemic immune modulation. Strahlentherapie Und Onkologie, 2009. 185: p. 117-117. 10. Urbonaviciute, V., Fuernrohr, B.G., Meister, S., Munoz, L., Heyder, P., Kalden, J.R., Manfredi, A.A., Bianchi, M.E., Rovere-Querini, P., Herrmann, M., and Voll, R.E., HMGB1-Nucleosome complexes from apoptotic cells initiate proinflammatory responses and induce Anti-DsDNA antibodies in mice. Arthritis and Rheumatism, 2008. 58(9): p. S320-S321. 11. Urbonaviciute, V., Fuernrohr, B., Meister, S., Heyder, P., Kalden, J.R., Herrmann, M., and Voll, R.E., High mobility group box protein 1 (HMGB1)-nucleosome complexes from apoptotic cells induce anti-dsDNA antibodies in non-autoimmune mice: Implications for etiopathogenesis of systemic lupus erythematosus. Annals of the Rheumatic Diseases, 2008. 67: p. A5-A5. 12. Urbonaviciute, V., Fernrohr, B., Meister, S., Heyder, P., Herrmann, M., Kalden, J.R., and Voll, R.E., HMGB1-nucleosome complexes from apoptotic cells induce inflammation and immune activation implications for the etiopathogenesis of systemic lupus erythematosus. Journal of Leukocyte Biology, 2008. 84(2): p. A20-A20. 13. Naschberger, E., Herrmann, M., Kretz, C., Krammer, P.H., Stuerzl, M., and Kuhn, A., Guanylate-binding protein-1: a novel marker in skin lesions of human lupuserythematosus. Experimental Dermatology, 2008. 17(3): p. 245-245. 14. Munoz, L.E., Grossmayer, G., Franz, S., Frey, B., Voll, R.E., Kalden, J.R., Schett, G., Herrmann, M., and Gaipl, U.S., Anti-dsDNA autoantibodies build immune-complexes with nuclear fragments in whole blood and mediate inflammation in patients with systemic lupus erythematosus (SLE). Annals of the Rheumatic Diseases, 2008. 67: p. A5-A5. 15. Janko, C., Schorn, C., Grossmayer, G., Gaipl, U., Herrmann, M., and Munoz, L., Anti-DSDNA autoantibodies mediate inflammatory clearance of nuclear fragments in whole blood in patients with SLE. Clinical and Experimental Rheumatology, 2008. 26(1): p. S89-S89. 16. Frey, B., Sieber, R., Schildkopf, P., Pausch, F., Roedel, F., Munoz, L., Janko, C., Herrmann, M., Sauer, R., and Gaipl, U.S., Annexin A5 (Anx A5) modulates the immune response towards apoptotic, secondary, and primary necrotic cells - implications for combined cancer therapies. Strahlentherapie Und Onkologie, 2008. 184: p. 51-51. 17. Frey, B., Roedel, F., Zech, C., Keilholz, L., Fietkau, R., Sauer, R., Herrmann, M., and Gaipl, U.S., Signalling cascades and interplay of immune cells after low dose radiotherapy. Strahlentherapie Und Onkologie, 2008. 184: p. 90-91. 18. Frey, B., Pausch, F., Roedel, F., Janko, C., Sieber, R., Schildkopf, P., Munoz, L.E., Herrmann, M., Sauer, R., and Gaipl, U.S., Annexin A5 is an important inflammatory modulator of immune responses against apoptotic and necrotic cells and should be accounted as molecular therapeutic for combined cancer therapies. Proceedings of the American Association for Cancer Research Annual Meeting, 2008. 49: p. 585. 19. Cooke, A., Ferraccioli, G.F., Herrmann, M., Romani, L., Schulze, C., Zampieri, S., and Doria, A., Induction and protection of autoimmune rheumatic diseases. The role of infections. Clinical and Experimental Rheumatology, 2008. 26(1): p. S1-S7. 20. Winkler, T.H., Herrmann, M., Kalden, J.R., and Wellmann, U., The origin of pathogenic autoantibodies in SLE. Zeitschrift Fur Rheumatologie, 2007. 66: p. 37-37. 21. Urbonaviciute, V., Fuernrohr, B., Weber, C., Heyder, P., Kalden, J.R., Herrmann, M., and Voll, R.E., HMGB1-containing nucleosomes released from secondary necrotic cells cause activation and cytokine release from monocytes/macrophages and dendritic cells - Implications for the immunopathogenesis of SLE. Annals of the Rheumatic Diseases, 2007. 66: p. A11-A11. 22. Frey, B., Janko, C., Sarter, K., Schulze, C., Franz, S., Munoz, L.E., Gaipl, U.S., and Herrmann, M., Apoptosis, necrosis and autoantibodies. Zeitschrift Fur Rheumatologie, 2007. 66: p. 99-99. 23. Neubert, K., Meister, S., Maseda, D., Amann, K., Herrmann, M., Kalden, J.R., and Voll, R.E., Proteasome inhibition for treatment of lupus in NZB/W mice. Arthritis and Rheumatism, 2006. 54(9): p. S453-S453. 24. Kuhn, A., Herrmann, M., Kleber, S., Beckmann, M., Fehsel, K., Martin-Villalba, A., Lehmann, P., Ruzicka, T., Kolb, B., and Krammer, P.H., Apoptotic cells accumulate in the skin of patients with cutaneous lupus erythematosus after UV irradiation. Journal of Investigative Dermatology, 2006. 126: p. 51-51. 25. Rodel, E., Muller, B., Sieber, R., Distel, L., Herrmann, M., Sauer, R., and Rodel, C., The apoptosis inhibitor Survivin influences cellular radiation sensitivity also through modulation of the cell cyclus and DNA repair. Strahlentherapie Und Onkologie, 2005. 181: p. 77-77. 26. Herrmann, M., Gaipl, U.S., Franz, S., Stach, C.M., Munoz, L., Sheriff, A., Voll, R.E., and Kaiden, J.R., Defective clearance of dying cells fosters the development of SLE. Annals of the Rheumatic Diseases, 2005. 64: p. 53-53. 27. Gaipl, U.S., Munoz, L.E., Appelt, U., Franz, S., Sheriff, A., Voll, R.E., Kalden, J.R., and Herrmann, M., Intrinsic clearance defects in systemic lupus erythematosus (SLE). Arthritis and Rheumatism, 2005. 52(9): p. S448-S448. 28. Franz, S., Gaipl, U.S., Appelt, U., Heyder, P., Voll, R.E., Kalden, J.R., and Herrmann, M., The role of a defective clearance in the pathogenesis of systemic lupus erythematosus. Arthritis Research & Therapy, 2004. 6: p. S34-S34. 29. Voll, R.E., Heyder, P., Gaipl, U.S., Manger, K., Beyer, T.D., Kalden, J.R., and Herrmann, M., Detection of the endogenous adjuvant Hmgb1 in circulating immuno-complexes from patients with systemic lupus erythematosus (SLE). Arthritis and Rheumatism, 2003. 48(9): p. S656-S656. 30. Gaipl, U.S., Voll, R.E., Beyer, T.D., Kladen, J.R., and Herrmann, M., Complement and DNase I co-operate in the effective clearance of dying cells. Arthritis and Rheumatism, 2003. 48(9): p. S591-S591. 31. Gaipl, U.S., Beyer, T.D., Voll, R.E., Franz, S., Kalden, J.R., and Herrmann, M., New aspects of the etiopathogenesis of systemic lupus erythematosus. Arthritis Research & Therapy, 2003. 5: p. S48-S48. 32. Stockmeyer, B., Beyer, T., Repp, R., Kalden, J.R., Valerius, T., and Herrmann, M., Polymorphonuclear Granulocytes Induce Antibody- Dependent Apoptosis in Breast Cancer Cells. Blood, 2002. 100(11): p. Abstract No. 3614. 33. Stockmeyer, B., Bever, T., Repp, R., Kalden, J.R., Valerius, T., and Herrmann, M., Polymorphonuclear Granulocytes induce antibody- dependent apoptosis in breast cancer cells. Blood, 2002. 100(11): p. 39B-39B. 34. Roedel, F., Voll, R., Haentschel, M., Herrmann, M., Beuscher, H.U., and Sauer, R., Dose-dependent biphasic expression of nuclear factor kappaB (NF-kappaB) in endothelial cells by low-dose ionizing radiation. International Journal of Radiation Oncology Biology Physics, 2001. 51(3 Supplement 1): p. 230-231. 35. Herold, C., Ganslmayer, M., Ocker, M., Herrmann, M., Hahn, E.G., and Schuppan, D., A combination of biomodulating agents induces multiple apoptotic pathways in HCC cells. Hepatology, 2001. 34(4): p. 501A-501A. 36. Rodel, F., Keilholz, L., Kern, P., Herrmann, M., Beuscher, H.U., and Sauer, R., Effect of low dose radiation on adhesion and apoptosis-discontinuous cytokine expression as one possible mechanism of action. International Journal of Radiation Oncology Biology Physics, 2000. 48(3 Supplement): p. 283. 37. Gaipl, U.S., Kuenkele, S., Voll, R.E., Kolowos, W., Kalden, J.R., and Herrmann, M., Complement binding of cells undergoing apoptosis or necrosis. Immunobiology, 2000. 203(1-2): p. 439. 38. Dimitrova, P., Skapenko, A., Schleyerbach, R., Herrmann, M., Kalden, J.R., and Schulze-Koops, H., Leflunomide inhibits proliferation of Th1 effectors and biases for Th2 cell differentiation. Immunobiology, 2000. 203(1-2): p. 477. 39. Burger, R., Bakker, F., Duerr, B., Herrmann, M., Guenther, A., and Gramatzki, M., Inhibition of myeloma cell growth by blocking intracellular signal transduction pathways. Acta Haematologica (Basel), 2000. 103(Supplement 1): p. 52. 40. Baumann, I., Herrmann, M., Manger, B., Voll, R.E., Kalden, J.R., and Kirchner, T., Impaired phagocytosis of apoptotic cells in lymphnodes of patients with systemic lupus erythematosus. Pathology Research and Practice, 2000. 196(6): p. 385. 41. Bakker, F., Burger, R., Duerr, B., Herrmann, M., Guenther, A., and Gramatzki, M., Inhibition of myeloma cell growth by blocking intracellular signal transduction pathways. Onkologie, 2000. 23(Sonderheft 7): p. 100. 42. Bakker, F., Burger, R., Duerr, B., Herrmann, M., Guenther, A., and Gramatzki, M., Components of the Ras/MAPK and Jak/STAT pathways as molecular targets for myeloma cell growth inhibition. Blood, 2000. 96(11): p. 751A-751A. 43. Kalden, J.R., Kollowos, V., Winkler, T., and Herrmann, M., Apoptosis and it's relevance to SLE. Journal of Autoimmunity, 1999(SUPPL.): p. 27. 44. Herrmann, M. and Haas, J.-P., Fas/Apo-1 mutation, necessary but not sufficient for development of Canale-Smith Syndrome. Journal of Autoimmunity, 1999(SUPPL.): p. 28. 45. Haas, J.P., Frank, C., Dirnecker, D., Kolowos, W., Herrmann, M., and Ruder, H., Persisting T-cell populations in idiopathic nephrotic syndrome of childhood. Human Immunology, 1999. 60(SUPPL. 2): p. S86. 46. Baumann, I., Herrmann, M., Harms, H., Puellhorn, H., and Kirchner, T., Apoptosis and T-cells in MDS. Leukemia Research, 1999. 23(SUPPL. 1): p. S20. 47. Kolowos, W., Hagenhofer, M., Fank, C., Kalden, J.R., and Herrmann, M., Clonally expanded CD4(+) T cells in peripheral blood of SLE patients. Arthritis and Rheumatism, 1998. 41(9): p. S74-S74. 48. Haas, J.P., Frank, C., Dirnecker, D., Kolowos, W., Leipold, G., Herrmann, M., and Ruder, H., Persisting T-cell population in idiopathic nephrotic syndrome of childhood. Kidney and Blood Pressure Research, 1998. 21(2-4): p. 142. 49. Geiler, T., Akkoc, N., State, M., Herrmann, M., Hieronymus, T., Lorenz, H.M., and Kalden, J.R., TNF alpha induced apoptosis in synovial fibroblasts. Arthritis and Rheumatism, 1998. 41(9): p. S143-S143. 50. Akkoc, N., Geiler, T., State, M., Herrmann, M., Hieronymus, T., Lorenz, H.M., and Kalden, J.R., Fas stimulation induces apoptosis in synovial fibroblasts in the presence of protein synthesis inhibition. Arthritis and Rheumatism, 1998. 41(9): p. S143-S143. 51. Perniok, A., Wedekind, F., Herrmann, M., Specker, C., and Schneider, M., High levels of circulating early apoptotic peripheral blood mononuclear cells in systemic lupus erythematosus. Arthritis and Rheumatism, 1997. 40(9): p. 1645-1645. 52. Kolowos, W., Frank, C., Voll, F., Ponner, B.B., Kalden, J.R., and Herrmann, M., Peripheral CD4 T cells from SLE patients display restricted junctional diversity of T cell receptor V beta genes. Arthritis and Rheumatism, 1997. 40(9): p. 801-801. 53. Haas, P.J., Hieronymus, T., Dimecker, D., Frank, C., Kolowos, W., Lorenz, H.- M., Leipold, G., Gruenke, M., and Herrmann, M., Increased spontaneous in vitro apoptosis in humans with Fas mutations. Arthritis and Rheumatism, 1997. 40(9 SUPPL.): p. S179. 54. Zoller, O.M., Voll, R., and Herrmann, M., Phagocytosis of apoptotic cells is reduced in patients with SLE. Faseb Journal, 1996. 10(6): p. 2067-2067. 55. Woith, W., Herrmann, M., Lottspeich, F., Nuesslein, I., Kalden, J.R., and Manger, B., Alternatively spliced transcripts of the human transferrin receptor (CD71) gene. Faseb Journal, 1996. 10(6): p. 231-231. 56. Voll, R.E., Roth, E., Herrmann, M., Fehr, H., Girkontaite, I., Lorenz, H.M., and Kalden, J.R., Histone-specific Th clones derived from systemic lupus erythematosus patients display a TH0- or TH1-like cytokine secretion pattern. Arthritis and Rheumatism, 1996. 39(9): p. 1326-1326. 57. Herrmann, M., Zoller, O.M., Voll, R., Teichmann, V., and Kalden, J.R., Non- inflammatory clearance of human apoptotic T-cells in mice. Faseb Journal, 1996. 10(6): p. 1936-1936. 58. Herrmann, M., Zoller, O.M., Hagenhofer, M., Voll, R., and Kalden, J.R., Macrophages from SLE patients have a reduced capacity to engulf apoptotic cells. Arthritis and Rheumatism, 1996. 39(9): p. 698-698. 59. Herrmann, M., Kolowos, W., Frank, C., and Kalden, J.R., Peripheral T cells from SLE patients are clonally activated. Arthritis and Rheumatism, 1996. 39(9): p. 1327-1327. 60. Gruenke, M., Lorenz, H.M., Hieronymus, T., Herrmann, M., Geiler, T., Heyder, P., Manger, B., and Kalden, J.R., Alterated in vitro apoptosis and expression of apoptosis-related molecules in SLE lymphocytes are phenomena non-specific for SLE. Arthritis and Rheumatism, 1996. 39(9 SUPPL.): p. S142. 61. Woith, W., Herrmann, M., Nuesslein, I., Kalden, J.R., and Manger, B., An alternatively spliced transcript of the human Transferrin receptor gene. Biological Chemistry Hoppe-Seyler, 1995. 376(SPEC. SUPPL.): p. S170. 62. Roberts, C.R., Herrmann, M., Aicher, W.K., Mullerladner, U., Matsumoto, S., Gay, R.E., Kalden, J.R., and Gay, S., SEQUENCES DERIVED FROM PCR AMPLIFICATION OF VIRUS-LIKE PARTICLES (VLP) PRESENT IN SYNOVIAL-FLUID OF PATIENTS WITH RHEUMATOID ARTHRITIS(RA). Arthritis and Rheumatism, 1995. 38(9): p. 388-388. 63. Herrmann, M. and Kalden, J.R., Determination of binding epitopes for anti- dsDNA auto-antibodies using a PCR assisted binding site selection. The 9th International Congress of Immunology, 1995: p. 838. 64. Herrmann, M., Hagenhofer, M., and Kalden, J.R., Binding motifs of anti-dsDNA autoantibodies. Biological Chemistry Hoppe-Seyler, 1995. 376(SPEC. SUPPL.): 65. Woith, W., Herrmann, M., Kalden, J.R., and Manger, B., Production of soluble transferrin receptor by human lymphocytes: An alternatively spliced mRNA possible encodes for the soluble protein. Immunobiology, 1994. 191(2-3): p. 91. 66. Lorenz, A.H.M., Woith, W., Herrmann, M., Geiler, T., Stell, J., Antoni, C., Kalden, J.R., and Manger, M., Anti-TNF-alpha-antibodies inhibit mixed lymphocyte reaction in synergism with cyclosporine. Immunobiology, 1994. 191(2-3): p. 184. 67. Herrmann, M., Geuder, A., Hagenhofer, M., and Kalden, J.R., Determination of recognition-sequences for anti-DNA auto-antibodies using a polymerase chain reaction assisted binding site selection method. Immunobiology, 1994. 191(2-3): p. 98-99. 68. Herrmann, M., Geuder, A., Hagenhofer, M., and Kalden, J.R., Determination of recognition-sequences for anti-DNA autoantibodies using a polymerase chain reaction assisted binding site selection method. Biological Chemistry Hoppe-Seyler, 1994. 375(SPEC. SUPPL. 1): p. S53. 69. Manger, B., Nuesslein, I., Woith, W., Winkler, T., Herrmann, M., and Kalden, J.R., RELEASE OF SOLUBLE TRANSFERRIN RECEPTOR TFR BY ACTIVATED HUMAN LYMPHOCYTES. Immunobiology, 1991. 183(3-4): p. 350. 70. Herrmann, M., Krapf, F.E., and Kalden, J.R., ANALYSIS OF RETROVIRAL GENES AND TRANSCRIPTS IN PATIENTS WITH AUTOIMMUNE DISEASES. Immunobiology, 1991. 183(3-4): p. 203. 71. Winkler, T.W., Herrmann, M., Fehr, H., Krapf, F., and Kalden, J.R., CHARACTERIZATION OF HUMAN MONOCLONAL ANTI-DNA ANTIBODIES FROM PATIENTS WITH SLE. Immunobiology, 1990. 181(2-3): p. 225. 72. Hawle, A., Neundoerfer, B., Sittel, R., Herrmann, M., Kewenik, M., and Altendorf-Hofmann, A., CURRENT CANCER PAIN THERAPY COMPARED TO WHO GUIDELINES WHAT IS THE GAP LIKE. Pain, 1990(SUPPL. 5): p. S363. 73. Leitmann, W., Herrmann, M., Krapf, F., and Kalden, J.R., RETROVIRAL DNA IN THE PLASMA OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS POSSIBLE PATHOGENETIC RELEVANCE. Journal of Cellular Biochemistry Supplement, 1989(13 PART B): p. 254. 74. Nurnberg, W., Winkler, T., Herrmann, M., Krapf, F., and Kalden, J.R., POLYNUCLEOTIDE ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS. Zeitschrift Fur Rheumatologie, 1988. 47(4): p. 253-253. 75. Leitmann, W., Herrmann, M., Krapf, F.E., and Kalden, J.R., MOLECULAR CHARACTERIZATION OF DNA ISOLATED FROM PLASMA OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. Journal of Cellular Biochemistry Supplement, 1988(12 PART E): p. 29. Leitmann, W., Herrmann, M., Krapf, F., and Kalden, J.R., CHARACTERIZATION OF NUCLEIC-ACIDS FROM PLASMA OF PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS. Zeitschrift Fur Rheumatologie, 1988. 47(4): p. 292-292. 77. Krapf, F., Farber, L., Manger, B., Herrmann, M., and Kalden, J.R., DEMONSTRATION AND INTERPRETATION OF DNA-ANTI-DNA IMMUNE-COMPLEXES IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS. Zeitschrift Fur Rheumatologie, 1988. 47(4): p. 292-293. 78. Huss, R., Krapf, E.F., Herrmann, M., Leitmann, W., Nurnberg, B., and Kalden, J.R., BINDING OF NUCLEIC-ACIDS TO A 42-KD POLYPEPTIDE IN THE ERYTHROCYTE-MEMBRANE COMPARED IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) AND HEALTHY CONTROLS. Zeitschrift Fur Rheumatologie, 1988. 47(4): p. 291-292. 79. Huss, R., Herrmann, M., Krapf, E.F., and Kalden, J.R., A 42-KD ERYTHROCYTE SURFACE-MEMBRANE PROTEIN WITH BINDING-CAPACITY TO POLYNUCLEOTIDES SHOWS FUNCTIONAL LACK IN SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE). Immunobiology, 1988. 178(1-2): p. 141-142. 80. Herrmann, M., Leitmann, W., Krapf, F.E., Rohwer, P., and Kalden, J.R., ASSOCIATION OF HUMAN RETROVIRUSES TO THE ETIOLOGY OF SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE). Immunobiology, 1988. 178(1-2): p. 139-140. 81. Herrmann, M., Leitmann, W., Krapf, F.E., and Kalden, J.R., IN-VITRO EFFECTS OF PLASMA NUCLEIC ACIDS ISOLATED FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS SLE. Journal of Cellular Biochemistry Supplement, 1988(12 PART E): p. 27. 82. Herrmann, M., Leitmann, W., Krapf, F., and Kalden, J.R., INVITRO NUCLEIC- ACID TRANSFECTION FROM PLASMA OF SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS. Zeitschrift Fur Rheumatologie, 1988. 47(4): p. 260-260. 83. Leitmann, W., Herrmann, M., Krapf, F.E., and Kalden, J.R., MOLECULAR- CLONING AND SEQUENCE-ANALYSIS OF PLASMA DNA FROM PATIENTS SUFFERING FROM SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE). Immunobiology, 1987. 175(4): p. 259-259. 84. Huss, R., Krapf, F.E., Herrmann, M., and Kalden, J.R., CLEARANCE OF POLYNUCLEOTIDES FROM PLASMA BY AN ERYTHROCYTE-MEMBRANE PROTEIN AND ITS SIGNIFICANCE FOR SYSTEMIC LUPUS-ERYTHEMATOSUS. Zeitschrift Fur Rheumatologie, 1987. 46(5): p. 270-270. 85. Herrmann, M., Krapf, F.E., Kern, P., Leitmann, W., and Kalden, J.R., CYTOPATHOGENIC EFFECT IN AN EBV IMMORTALIZED B CELL LINE AFTER COINCUBATION WITH NUCLEIC ACIDS ISOLATED FROM PLASMA OF PATIENTS SUFFERING FROM SYSTEMIC LUPUS ERYTHEMATOSUS SLE. Immunobiology, 1987. 175(4): p. 255-256. 86. Herrmann, M., Krapf, F.E., Kern, P., Leitmann, W., and Kalden, J.R., CYTOPATHOGENIC EFFECT IN AN EBV IMMORTILIZED B-CELL LINE AFTER COINCUBATION WITH NUCLEIC-ACIDS ISOLATED FROM PLASMA OF PATIENTS SUFFERING FROM SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE). Immunobiology, 1987. 175(4): p. 254-255. 87. Bogelein, A., Manger, B., Herrmann, M., Krapf, F., and Kalden, J.R., PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST NUCLEIC-ACIDS FROM PLASMA OF PATIENTS SUFFERING FROM SYSTEMIC LUPUS-ERYTHEMATOSUS. Immunobiology, 1987. 175(4): p. 253-253. 88. Herrmann, M., Krapf, F., and Kalden, J.R., ANTIBODY-BOUND HIGH MOLECULAR DNA AND RNA IN THE PLASMA OF PATIENTS WITH SLE. Zeitschrift Fur Rheumatologie, 1986. 45(4): p. 219-220. 89. Herrmann, M., Krapf, F., and Kalden, J.R., ANTIBODY FIXING HIGH- MOLECULAR-WEIGHT DNA AND RNA IN SLE PATIENTS PLASMAS. Immunobiology, 1986. 173(2-5): p. 334-334. 90. Fuchs, C., Ruger, A., Blum, R., Herrmann, M., Krapf, F., and Kalden, J.R., IMMUNOGLOBULIN CLASSES AND IGG-SUBCLASS-SPECIFIC EVIDENCE OF C3-INCLUDING CIRCULATING IMMUNE-COMPLEXES. Zeitschrift Fur Rheumatologie, 1986. 45(4): p. 220-220. 91. Krapf, F., Herrmann, M., Kolble, K., Linhart, H., and Kalden, J.R., SCREENING AND CHARACTERIZATION OF CIRCULATING IMMUNE-COMPLEXES (CIC) BY A SOLID-PHASE ANTI C-3 AND ANTI C-4 ASSAY AND FITC LABELED 2ND ANTIBODY. Immunobiology, 1984. 168(1-2): p. 62-62. 92. Herrmann, M., Krapf, F., Linhart, H., and Kalden, J.R., MONITORING OF IMMUNE-COMPLEX PREPARATIONS FROM PLASMAPHERESIS FLUIDS USING A NEW ASSAY SYSTEM. Immunobiology, 1984. 168(1-2): p. 106-107. Liste der laufenden externen Drittmittel
• “Radonbehandlung der TNF-transgenen Maus als Modell der Arthritis” Principal Investigator: Martin Herrmann, 10 % effort Funding Agency: Privatstiftung als Rechtsträger des Forschungsinstituts Gastein (FOI) der Parcelsus Medizinischen Privatuniversität This project to prove the thesis, that with radon therapie the nests of apoptotic cells ncrease, that stimulate Phagozyten to set TGF-ß free. • “Inflammation in crystal arthropathies” Principal Investigator: Martin Herrmann; 20% effort Funding Agency: Interdisciplinary Centre of Clinical Research (IZKF); 10/01/2010-09/30/2013 This project addresses the molecular mechanism of inflammation in crystal arthropaties • International Cooperation in Education and Science with the Ukraine • “Veränderungen in der Glykokalyx der Plasmamembranen von apoptotischen Zellen. Auswirkungen für Autoimmunität“ Principal Investigator: Martin Herrmann; 5% effort Funding Agency: German Federal Department of Education and Science Project UKR 08/035 This project addresses the changes in the Glykokalyx of plasma membranes of apoptotic cells, and its impact for autoimmunity. since 04/2009 • “Human C-reactive protein as therapeutical target” Principal Investigator: Martin Herrmann; 5% effort Funding Agency: K und R Wucherpfennig Stiftung This project aims to study the importance of CRP in organ damage since 12/2008 • “Strategien der zellulären Immunintervention” Leader of graduate school: Martin Herrmann; 10% effort Funding Agency: Collaborative Research Centre No.643; 07/01/08-06/30/2012 This project is a graduate school connected to the Collaborative Research Centre (SFB) No.643. since 07/2008 • “Disturbed clearance of apoptotic cells in germinal centres – reason for the anti- dsDNA autoantibodies in MFG-E8 knockout mice” Principal Investigator: Martin Herrmann; 20% effort Funding Agency: Interdisciplinary Centre of Clinical Research (IZKF); 10/01/07-12/31/2010 This project addresses the role of clearance of apoptotic cells for the induction of anti dsDNA autoantibodies in a knock-in mouse system. since 10/2007 • “Modulation of Phagocytosis and inflammation with the phosphatidylserine-ligand Annexin A5” Principal Investigator: Martin Herrmann; 10% effort Funding Agency: Collaborative Research Centre (SFB) No.643; 08/01/04-06/30/2008 This project tests the role of the PS-binding protein annexin A5 in the modulation of immune responses against dying and dead cells. since 09/2004 second period since 09/2008. 2. Bisherige Aktivitäten in der Graduierten -
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3. Projektskizze
Allgemeinprojektskizze der AG-Herrmann
Wir arbeiten seit Jahren an der Ätiopathogenese der systemischen Autoimmunität. Systemischer Lupus Erythematodes (SLE) ist eine prototypische chronisch-entzündliche Autoimmunerkrankung, die durch das Auftreten einer Vielzahl von Autoantikörpern gekennzeichnet ist. Die Autoantikörper sind gegen Zellkernbestandteile gerichtet und haben große pathogenische Bedeutung. Dennoch sind die Etiopathogenese der Autoimmunreaktionen und die Chronifizierung der Entzündung derzeit noch nicht vollständig verstanden. Wir haben gezeigt, dass bei der Entstehung und Chronifizierung des SLE eine Fehlregulation der Clearance apoptotischer Zellen eine Rolle spielt. Die spezifische Erkennung und Aufnahme apoptotischer Zellen durch Phagozyten ist bei Patienten mit SLE eingeschränkt. Werden sterbende Zellen nicht rechtzeitig beseitigt, gehen sie in die späten Phasen des Zelltodes über. Geht dabei die Membranintegrität verloren (sekundäre Nekrose), gelangt toxisches und pro-inflammatorisches intrazelluläres Material in das umliegende Gewebe und ruft dort Entzündungsreaktionen hervor, die die Entstehung von Autoimmunreaktionen begünstigen. Die anti-inflammatorische Clearance wird durch Komplement und opsonisierende Adaptermoleküle im Serum vermittelt. Verschiedene Phagozyten-Rezeptoren (αvβ3 Integrin, der β2-GPI Rezeptor, sowie die Rezeptor-Tyrosin Kinase Mer) binden an PS über das jeweils dazugehörige Brückenmolekül (MFG-E8, β2-GPI, gas6). Die apoptotischen Zellen werden dann unmittelbar von den Phagozyten aufgenommen. Um sekundäre Nekrose und Autoimmunität zu vermeiden muss zudem eine zweite Reihe an Signalen an der Oberfläche der sterbenden Zellen erscheinen, welche die Clearance der spät apoptotischen Zellen unterstützen. Verschiedene nicht PS spezifische Brückenmoleküle, wie zum Beispiel CRP, C1q, Surfactant Protein A und D, Mannose bindendes Lektin und andere Lektine sind bekannt an spät apoptotische Zellen zu binden. Die spezifischen Epitope auf der apoptotische Oberfläche und die Rezeptoren auf den Phagozyten werden aktuell von unserer Gruppe erforscht. Die Akkumulation sekundärnekrotischer Zellenreste (SNEC) in Anwesenheit von Autoantikörpern gegen apoptotische Zellen oder gegen Adaptormoleküle für diese Zellen erzwingt deren pathologische Elimination und unterhält die Entzündung. Die SLE-typischen Autoimmunreaktionen sind gegen komplexe, nukleinsäurehaltige Antigene gerichtet. Wir haben die Hypothese aufgestellt, dass die Pathogenität von Autoantikörpern stark ansteigt falls Autoantigene für die Immunkomplexbildung zugänglich sind. Letztere können dann als binäre Pyrogene betrachtet werden, die aus weniger entzündlichen Einzelkomponenten zusammengesetzt sind. Die Anwesenheit der Autoantigene als Folge einer gestörten Beseitigung apoptotischer Zellen wird auch in der Humanenmodel untersucht. Die häufigste Kristallarthritis ist die Gicht, bei der Monosodiumuratkristalle (MSU) pro-inflammatorische Mediatoren aus Leukozyten freisetzen. Hierbei spielt IL-1ß die zentrale Rolle. Die IL-1ß Prozessierung und Sekretion werden über das NALP3 Inflammasom reguliert, das aktiviert wird, wenn die intrazelluläre K+-Konzentration [K +i] unter 90mM fällt. Wir untersuchen die Mechanismen die zur NALP3-Aktivierung durch MSU führen um die Entzündungskaskade in den Kristallarthropathien zu charakterisieren. Insbesondere wird der Einfluss auf die Ausbildung von „neutrophil extracellular traps“ (NETs) analysiert. Die Ergebnisse dieser Untersuchungen sollen in einem translationalen Ansatz der Einfluss von Chloroquin als Inhibitor der Lysosomenazidifizierung auf die Entzündungsreaktion in Gichtpatienten

Source: http://www.grk643.de/SiteCollectionDocuments/Forschungsprofil%20Martin%20Herrmann%2010.2010.pdf