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The new england journal of medicineof the Randomized Aldactone Evaluation StudyDavid N. Juurlink, M.D., Ph.D., Muhammad M. Mamdani, Pharm.D., M.P.H., Douglas S. Lee, M.D., Alexander Kopp, B.A., Peter C. Austin, Ph.D., Andreas Laupacis, M.D., and Donald A. Redelmeier, M.D. b a c k g r o u n d The Randomized Aldactone Evaluation Study (RALES) demonstrated that spironolac- From the Depart