Eprints.kmu.ac.ir

Kerman university of medical sciences, kerman, iran. http://www.kmu.ac.ir Antimicrobial resistance pattern of Escherichia coli causing urinary tract infections, and that of human fecal flora, in the southeast of Iran
Author(s): Mansouri, S (Mansouri, S); Shareifi, S (Shareifi, S)
Source: MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND
DISEASE Volume: ٨ Issue: ٢ Pages: ١٢٣-١٢٨ DOI:١٠.١٠٨٩/١٠٧٦٦٢٩٠٢٧٦٠١٩٠٦٦٢ Published: SUM ٢٠٠٢
Times Cited: ٥ (from Web of Science)
Cited References: ٢١ [ view related records ]
Citation Map
Abstract: Sensitivity of ٥٠٠ Escherichia coli isolates from urinary tract infections (UTIs, ٣١١ isolate) and fecal
samples (١٨٩ isolates) was tested against ١٢ antimicrobial agents using the standard disk diffusion method. Although the rate of resistance to antimicrobial agents was higher in the UTIs, in comparison with the fecal samples, the only significant difference was found in cases of tetracycline (p = ٠.٠٠٨), nalidixic acid (p = ٠.٠٣٨), and trimethoprim- sulfamethoxazole (Sxt, p = ٠.٠٥). The pattern of sensitivity to antimicrobial agents with respect to statistical y significant difference in the number of sensitive isolates (p less than or equal to ٠.٠١) was: ceftizoxime (٩٩.٤%) and ceftriaxone (٩٩.٢%) > gentamicin (٩٧.٨%), ciprofloxacin (٩٣%) and nitrofurantoin (٩٢%) > cefazoline (٨٥.٢%) and nalidixic acid (٨٤.٦%) > chloramphenicol (٧١.٦%), cephradine (٦٩.٦%) and tetracycline (٦٣.٢%) > Sxt (٤١.٦%) > ampicil in (٢٣.٢%). Sensitivity of the isolates in respect to sex and age was also determined and compared during this study. Resistance to three or more antimicrobial agents (multidrug resistance, MDR) was found in ٢٠٩ (٤١.٨%) of the isolates. The high rate of resistance to Sxt and the presence of a high rate of MDR isolates in this area suggest that a reevaluation of the first-line therapeutic may be necessary for the treatment of UTIs in this area.
Accession Number: WOS:٠٠٠١٧٦٦٣٢١٠٠٠٠٦
Document Type: Article
Language: English
KeyWords Plus: SUSCEPTIBILITY; CIPROFLOXACIN; TRAVELERS; DIARRHEA; EFFLUX
Reprint Address: Mansouri, S (reprint author), Kerman Univ Med Sci, Dept Microbiol, POB ٤٤٤, Kerman
٧٦١٦٩١٤١١١, Iran
Addresses:
١. Kerman Univ Med Sci, Dept Microbiol, Kerman ٧٦١٦٩١٤١١١, Iran
Publisher: MARY ANN LIEBERT INC PUBL, ٢ MADISON AVENUE, LARCHMONT, NY ١٠٥٣٨ USA
Web of Science Category: Infectious Diseases; Microbiology; Pharmacology & Pharmacy
Subject Area: Infectious Diseases; Microbiology; Pharmacology & Pharmacy
IDS Number: ٥٦٩YZ
ISSN: ١٠٧٦-٦٢٩٤

Source: http://eprints.kmu.ac.ir/3551/1/39.pdf