50 einfache dinge, die sie über das altern wissen sollten

50 einfache Dinge, die Sie über das Altern wissen sollten
Cem Ekmekcioglu
Literaturhinweise (sortiert nach Zitierung im Text)
1. Morley JE. A brief history of geriatrics. J Gerontol A Biol Sci Med Sci 2004; 59: 1132-52.
2. Faust V. Über das Alter und Altern. Psychiatrie heute.
3. Viidik A. The biological aging is our inescapable fate--but can we modify it? Z Gerontol Geriatr 1999; 32:
4. Birkenstock E, Rentsch T. [Towards a sheltered aging in individual and social responsibility]. Z Gerontol Geriatr 2005; 38: 242-8.
5. Obermuller K. [On the wisdom and stupidity of getting older--a progress report]. Ther Umsch 2005; 62: 797-
6. Kiesel H. Das Alter in der Literatur. In: Häfner H, Staudinger UM, eds. Was ist Alter: Springer Verlag, 2008. 7. Bobbio N. Vom Alter. München: Piper, 1996/1999. 8. Spiegel, Online, Kultur, Projekt, Gutenberg. Cato oder Von dem Greisenalter, Marcus Tullius Cicero. 9. Levy BR, Slade MD, Kunkel SR, Kasl SV. Longevity increased by positive self-perceptions of aging. J Pers Soc Psychol 2002; 83: 261-70.
10. Walter U, Schneider N, Bisson S. [Morbidity and health in old age. A challenge for prevention and health care]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2006; 49: 537-46.
11. Bowling A, Gabriel Z, Dykes J, et al. Let's ask them: a national survey of definitions of quality of life and its enhancement among people aged 65 and over. Int J Aging Hum Dev 2003; 56: 269-306.
12. Netuveli G, Blane D. Quality of life in older ages. Br Med Bull 2008; 85: 113-26.
13. Newton JP. GOTYS - getting older, thinking younger. Gerontology 2007; 24: 187-8.
14. Stetson C, Fiesta MP, Eagleman DM. Does time really slow down during a frightening event? PLoS ONE
2007; 2: e1295.
15. Wallish P. An Odd Sense of Timing. Scientific American 2008.
16. de Beauvoir S. das Alter: Rororo.
17. Rosenmayr L. Schöpferisches Altern: Eine Philosophie des Lebens: Lit Verlag, 2007.
18. Sohngen M, Smith RJ. Images of old age in poetry. Gerontologist 1978; 18: 181-6.
19. Mulley G. Myths of ageing. Clin Med 2007; 7: 68-72.
20. Cohen JE. Human population: the next half century. Science 2003; 302: 1172-5.
21. Kocka J. Chancen und Herausforderungen einer alternden Gesellschaft. Altern-in-Deutschland.de.
22. Lebensqualität im Alter: Therapie und Prophylaxe von Altersleiden: Springer Wien New York, 2005.
23. Zeyfang A, Hagg-Grün U, Nikolaus T. Basiswissen Medizin des Alterns und des alten Menschen: Springer
24. Capri M, Salvioli S, Sevini F, et al. The genetics of human longevity. Ann N Y Acad Sci 2006; 1067: 252-
25. Müller WA, Hassel M. Entwicklungsbiologie und Reproduktionsbiologie von Mensch und Tieren. Ein einführendes Lehrbuch: Springer Berlin, 2005. 26. Olsen A, Vantipalli MC, Lithgow GJ. Using Caenorhabditis elegans as a model for aging and age-related diseases. Ann N Y Acad Sci 2006; 1067: 120-8.
27. Rattan SI, Singh R. Progress & prospects: gene therapy in aging. Gene Ther 2009; 16: 3-9.
28. Grupe G, Kerrin C, Schröder I, Wittwer-Backofen U. Anthropologie: Ein einführendes Lehrbuch: Springer
29. Browner WS, Kahn AJ, Ziv E, et al. The genetics of human longevity. Am J Med 2004; 117: 851-60.
30. Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, Auwerx J. Sirtuins: the 'magnificent seven',
function, metabolism and longevity. Ann Med 2007; 39: 335-45.
31. Flachsbart F, Caliebe A, Kleindorp R, et al. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci USA 2009. 32. Willcox BJ, Donlon TA, He Q, et al. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A 2008; 105: 13987-92.
33. Jiang H, Ju Z, Rudolph KL. Telomere shortening and ageing. Z Gerontol Geriatr 2007; 40: 314-24.
34. Aviv A, Valdes AM, Spector TD. Human telomere biology: pitfalls of moving from the laboratory to
epidemiology. Int J Epidemiol 2006; 35: 1424-9.
35. Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann N Y Acad Sci 2006; 1067: 10-21.
36. Gruber J, Schaffer S, Halliwell B. The mitochondrial free radical theory of ageing--where do we stand? Front Biosci 2008; 13: 6554-79.
37. Shanley DP, Sear R, Mace R, Kirkwood TB. Testing evolutionary theories of menopause. Proc Biol Sci 2007; 274: 2943-9.
38. Schmidt T, Schwartz FW, Walter U. Physiologische Potentiale der Langlebigkeit und Gesundheit im evolutionsbiologischen und kulturellen Kontext- Grundvorraussetzung für ein produktives Leben. 39. Vaiserman AM, Koshel NM, Litoshenko AY, Mozzhukhina TG, Voitenko VP. Effects of X-irradiation in early ontogenesis on the longevity and amount of the S1 nuclease-sensitive DNA sites in adult
Drosophila melanogaster. Biogerontology 2003; 4: 9-14.
40. Rattan SI. Hormesis in aging. Ageing Res Rev 2008; 7: 63-78.
41. Luy M. [Sex differences in mortality - time to take a second look]. Z Gerontol Geriatr 2002; 35: 412-29.
42. Eskes T, Haanen C. Why do women live longer than men? Eur J Obstet Gynecol Reprod Biol 2007; 133:
43. Vina J, Sastre J, Pallardo F, Borras C. Mitochondrial theory of aging: importance to explain why females live longer than males. Antioxid Redox Signal 2003; 5: 549-56.
44. Hamilton JB, Mestler GE. Mortality and survival: comparison of eunuchs with intact men and women in a mentally retarded population. J Gerontol 1969; 24: 395-411.
45. Shames RS. Gender differences in the development and function of the immune system. J Adolesc Health 2002; 30: 59-70.
46. Likar R, Bernatzky G, Pipam W, Janig H, Sadjak A, eds. Lebensqualität im Alter. Wien New York: Springer 47. Staudinger UM, Häfner H, eds. Was ist Alter(n): Springer, Robert Bosch Stiftung, 2008.
48. Carrel A. Physiological Time. Science 1931; 74: 618-621.
49. Shay JW, Wright WE. Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol 2000; 1: 72-6.
50. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-
51. Olovnikov AM. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 1973; 41: 181-90.
52. Dean W. Biomarker research in gerontology. Exp Gerontol 1988; 23: 139-42.
53. Simm A, Nass N, Bartling B, Hofmann B, Silber RE, Navarrete Santos A. Potential biomarkers of ageing.
Biol Chem 2008; 389: 257-65.
54. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003; 361: 393-5.
55. Candore G, Balistreri CR, Listi F, et al. Immunogenetics, gender, and longevity. Ann N Y Acad Sci 2006; 1089: 516-37.
56. Candore G, Colonna-Romano G, Balistreri CR, et al. Biology of longevity: role of the innate immune system. Rejuvenation Res 2006; 9: 143-8.
57. Roth GS, Lane MA, Ingram DK, et al. Biomarkers of caloric restriction may predict longevity in humans. Science 2002; 297: 811.
58. Juhaszova M, Rabuel C, Zorov DB, Lakatta EG, Sollott SJ. Protection in the aged heart: preventing the heart-break of old age? Cardiovasc Res 2005; 66: 233-44.
59. AbuMweis SS, Jones PJ. Cholesterol-lowering effect of plant sterols. Curr Atheroscler Rep 2008; 10: 467-
60. Klinke R, Pape H-C, Silbernagl S, eds. Physiologie: Thieme Verlag, 2005.
61. Schmidt RF, Lang F, eds. Physiologie des Menschen: Springer Verlag, 2007.
62. Martin M. [Memory and planning]. Ther Umsch 2005; 62: 801-6.
63. Craik FI, Bialystok E. Cognition through the lifespan: mechanisms of change. Trends Cogn Sci 2006; 10:
64. Hultsch DF, MacDonald SW, Dixon RA. Variability in reaction time performance of younger and older adults. J Gerontol B Psychol Sci Soc Sci 2002; 57: P101-15.
65. Anstey KJ, Low LF. Normal cognitive changes in aging. Aust Fam Physician 2004; 33: 783-7.
66. Jonker C, Geerlings MI, Schmand B. Are memory complaints predictive for dementia? A review of clinical
and population-based studies. Int J Geriatr Psychiatry 2000; 15: 983-91.
67. Kurz A, Diehl J, Riemenschneider M, Perneczky R, Lautenschlager N. [Mild cognitive disorder. Questions of definition, diagnosis, prognosis and therapy]. Nervenarzt 2004; 75: 6-15.
68. Perneczky R, Alexopoulos P, Kurz A. [Mild cognitive impairment]. MMW Fortschr Med 2004; 146: 34-7.
69. ÖGAM. Demenz-Früherkennung in der allgemeinmedizinschen Praxis-Konsensus Statement, 2004.
70. Smith RG, Betancourt L, Sun Y. Molecular endocrinology and physiology of the aging central nervous
system. Endocr Rev 2005; 26: 203-50.
71. Kramer AF, Bherer L, Colcombe SJ, Dong W, Greenough WT. Environmental influences on cognitive and brain plasticity during aging. J Gerontol A Biol Sci Med Sci 2004; 59: M940-57.
72. Fritsch T, McClendon MJ, Smyth KA, Lerner AJ, Friedland RP, Larsen JD. Cognitive functioning in healthy aging: the role of reserve and lifestyle factors early in life. Gerontologist 2007; 47: 307-22.
73. Eisch AJ, Cameron HA, Encinas JM, Meltzer LA, Ming GL, Overstreet-Wadiche LS. Adult neurogenesis, mental health, and mental illness: hope or hype? J Neurosci 2008; 28: 11785-91.
74. Milgram NW, Siwak-Tapp CT, Araujo J, Head E. Neuroprotective effects of cognitive enrichment. Ageing Res Rev 2006; 5: 354-69.
75. Wilson RS, Mendes De Leon CF, Barnes LL, et al. Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA 2002; 287: 742-8.
76. Riley KP, Snowdon DA, Desrosiers MF, Markesbery WR. Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study. Neurobiol Aging 2005; 26: 341-7.
77. Bosma H, van Boxtel MP, Ponds RW, Houx PJ, Burdorf A, Jolles J. Mental work demands protect against cognitive impairment: MAAS prospective cohort study. Exp Aging Res 2003; 29: 33-45.
78. Kormi-Nouri R, Shojaei RS, Moniri S, et al. The effect of childhood bilingualism on episodic and semantic memory tasks. Scand J Psychol 2008; 49: 93-109.
79. Rivera Mindt M, Arentoft A, Kubo Germano K, et al. Neuropsychological, cognitive, and theoretical considerations for evaluation of bilingual individuals. Neuropsychol Rev 2008; 18: 255-68.
80. Acevedo A, Loewenstein DA. Nonpharmacological cognitive interventions in aging and dementia. J Geriatr Psychiatry Neurol 2007; 20: 239-49.
81. Buiza C, Etxeberria I, Galdona N, et al. A randomized, two-year study of the efficacy of cognitive intervention on elderly people: the Donostia Longitudinal Study. Int J Geriatr Psychiatry 2008; 23: 85-
94.
82. Willis SL, Tennstedt SL, Marsiske M, et al. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA 2006; 296: 2805-14.
83. Lim WS, Gammack JK, Van Niekerk J, Dangour AD. Omega 3 fatty acid for the prevention of dementia. Cochrane Database Syst Rev 2006: CD005379.
84. Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch
Neurol 2006; 63: 1402-8.
85. Ancelin ML, Christen Y, Ritchie K. Is antioxidant therapy a viable alternative for mild cognitive impairment? Examination of the evidence. Dement Geriatr Cogn Disord 2007; 24: 1-19.
86. Jia X, McNeill G, Avenell A. Does taking vitamin, mineral and fatty acid supplements prevent cognitive decline? A systematic review of randomized controlled trials. J Hum Nutr Diet 2008; 21: 317-36.
87. Angevaren M, Aufdemkampe G, Verhaar HJ, Aleman A, Vanhees L. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database
Syst Rev 2008: CD005381.
88. Colcombe SJ, Kramer AF, McAuley E, Erickson KI, Scalf P. Neurocognitive aging and cardiovascular fitness: recent findings and future directions. J Mol Neurosci 2004; 24: 9-14.
89. Larson EB, Wang L, Bowen JD, et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med 2006; 144: 73-81.
90. Salles N. Basic mechanisms of the aging gastrointestinal tract. Dig Dis 2007; 25: 112-7.
91. Gagliano N, Grizzi F, Annoni G. Mechanisms of aging and liver functions. Dig Dis 2007; 25: 118-23.
92. McCullough JL, Kelly KM. Prevention and treatment of skin aging. Ann N Y Acad Sci 2006; 1067: 323-31.
93. Baumann L. Skin ageing and its treatment. J Pathol 2007; 211: 241-51.
94. Grether-Beck S, Wlaschek M, Krutmann J, Scharffetter-Kochanek K. [Photodamage and photoaging--
prevention and treatment]. J Dtsch Dermatol Ges 2005; 3 Suppl 2: S19-25.
95. Farage MA, Miller KW, Elsner P, Maibach HI. Intrinsic and extrinsic factors in skin ageing: a review. Int J Cosmet Sci 2008; 30: 87-95.
96. Phillips TJ, Symons J, Menon S. Does hormone therapy improve age-related skin changes in postmenopausal women? A randomized, double-blind, double-dummy, placebo-controlled multicenter study assessing
the effects of norethindrone acetate and ethinyl estradiol in the improvement of mild to moderate age-
related skin changes in postmenopausal women. J Am Acad Dermatol 2008; 59: 397-404 e3.
97. Schneider LA, Wlaschek M, Scharffetter-Kochanek K. [Skin aging--clinical aspects and pathogenesis]. J Dtsch Dermatol Ges 2003; 1: 223-32; quiz 233-4.
98. Samuel M, Brooke RC, Hollis S, Griffiths CE. Interventions for photodamaged skin. Cochrane Database Syst Rev 2005: CD001782.
99. Haftek M, Mac-Mary S, Le Bitoux MA, et al. Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. Exp
Dermatol 2008; 17: 946-52.
100. Farris PK. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg 2005; 31: 814-7; discussion 818.
101. Heinrich U, Neukam K, Tronnier H, Sies H, Stahl W. Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. J Nutr 2006;
136: 1565-9.
102. Roberts SB, Rosenberg I. Nutrition and aging: changes in the regulation of energy metabolism with aging. Physiol Rev 2006; 86: 651-67.
103. Roberts SB, Fuss P, Heyman MB, et al. Control of food intake in older men. Jama 1994; 272: 1601-6.
104. Clarkston WK, Pantano MM, Morley JE, Horowitz M, Littlefield JM, Burton FR. Evidence for the anorexia
of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults. Am J Physiol 1997;
272: R243-8.
105. de Castro JM, de Castro ES. Spontaneous meal patterns of humans: influence of the presence of other people. Am J Clin Nutr 1989; 50: 237-47.
106. Ache BW, Young JM. Olfaction: diverse species, conserved principles. Neuron 2005; 48: 417-30.
107. Albrecht J, Wiesmann M. [The human olfactory system. Anatomy and physiology]. Nervenarzt 2006; 77:
108. Murphy C, Schubert CR, Cruickshanks KJ, Klein BE, Klein R, Nondahl DM. Prevalence of olfactory impairment in older adults. Jama 2002; 288: 2307-12.
109. Schrader WF. [Age-related macular degeneration: a socioeconomic time bomb in our aging society]. Ophthalmologe 2006; 103: 742-8.
110. Rehak M, Fric E, Wiedemann P. [Lutein and antioxidants in the prevention of age-related macular degeneration]. Ophthalmologe 2008; 105: 37-8, 40-5.
111. Evans JR, Henshaw K. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database Syst Rev 2008: CD000253.
112. Barzel US, Massey LK. Excess dietary protein can adversely affect bone. J Nutr 1998; 128: 1051-3.
113. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and
vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J
Clin Nutr 1999; 69: 727-36.
114. Sebastian A, Sellmeyer DE, Stone KL, Cummings SR. Dietary ratio of animal to vegetable protein and rate of bone loss and risk of fracture in postmenopausal women. Am J Clin Nutr 2001; 74: 411-2.
115. Sebastian A, Harris ST, Ottaway JH, Todd KM, Morris RC, Jr. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 1994; 330:
1776-81.
116. Teucher B, Fairweather-Tait S. Dietary sodium as a risk factor for osteoporosis: where is the evidence? Proc Nutr Soc 2003; 62: 859-66.
117. Harrington M, Cashman KD. High salt intake appears to increase bone resorption in postmenopausal women but high potassium intake ameliorates this adverse effect. Nutr Rev 2003; 61: 179-83.
118. Pfister G, Herndler-Brandstetter D, Grubeck-Loebenstein B. [Results from biomedical aging research. Trends and current examples from immunology]. Bundesgesundheitsblatt Gesundheitsforschung
Gesundheitsschutz 2006; 49: 506-12.
119. Martin BK, Szekely C, Brandt J, et al. Cognitive function over time in the Alzheimer's Disease Anti- inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and
celecoxib. Arch Neurol 2008; 65: 896-905.
120. Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology 2007; 120: 435-46.
121. Dorshkind K, Montecino-Rodriguez E, Signer RA. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol 2009; 9: 57-62.
122. Goodwin K, Viboud C, Simonsen L. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 2006; 24: 1159-69.
123. Lio D, Scola L, Crivello A, et al. Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP. J
Med Genet 2003; 40: 296-9.
124. Johnson AR, Munoz A, Gottlieb JL, Jarrard DF. High dose zinc increases hospital admissions due to genitourinary complications. J Urol 2007; 177: 639-43.
125. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2008:
CD007176.
126. Nova E, Warnberg J, Gomez-Martinez S, Diaz LE, Romeo J, Marcos A. Immunomodulatory effects of probiotics in different stages of life. Br J Nutr 2007; 98 Suppl 1: S90-5.
127. O'Neil J, Hughes S, Lourie A, Zweifler J. Effects of echinacea on the frequency of upper respiratory tract symptoms: a randomized, double-blind, placebo-controlled trial. Ann Allergy Asthma Immunol 2008;
100: 384-8.
128. Henderson J. Ernest Starling and 'Hormones': an historical commentary. J Endocrinol 2005; 184: 5-10.
129. Sherlock M, Toogood AA. Aging and the growth hormone/insulin like growth factor-I axis. Pituitary 2007;
10: 189-203.
130. Chahal HS, Drake WM. The endocrine system and ageing. J Pathol 2007; 211: 173-80.
131. Peeters RP. Thyroid hormones and aging. Hormones (Athens) 2008; 7: 28-35.
132. Karlamangla AS, Singer BH, Chodosh J, McEwen BS, Seeman TE. Urinary cortisol excretion as a predictor of incident cognitive impairment. Neurobiol Aging 2005; 26 Suppl 1: 80-4.
133. Evans P, Forte D, Jacobs C, et al. Cortisol secretory activity in older people in relation to positive and negative well-being. Psychoneuroendocrinology 2007; 32: 922-30.
134. Lai JC, Evans PD, Ng SH, et al. Optimism, positive affectivity, and salivary cortisol. Br J Health Psychol 2005; 10: 467-84.
135. Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005; 26: 833-76.
136. Bischof K. [Men and women--aspects of sexological counseling in the aging]. Ther Umsch 2005; 62: 807-
137. Kingsberg SA. The psychological impact of aging on sexuality and relationships. J Womens Health Gend Based Med 2000; 9 Suppl 1: S33-8.
138. Berberich HJ. [Sexuality in the aged]. Urologe A 2004; 43: 1076-81.
139. Nusbaum MR, Lenahan P, Sadovsky R. Sexual health in aging men and women: addressing the physiologic
and psychological sexual changes that occur with age. Geriatrics 2005; 60: 18-23.
140. Ginsberg TB. Aging and sexuality. Med Clin North Am 2006; 90: 1025-36.
141. Hofman MA, Swaab DF. Living by the clock: the circadian pacemaker in older people. Ageing Res Rev
2006; 5: 33-51.
142. Drust B, Waterhouse J, Atkinson G, Edwards B, Reilly T. Circadian rhythms in sports performance--an update. Chronobiol Int 2005; 22: 21-44.
143. Koch HJ, Raschka C, Wirth K. Tagesschwankungen der körperlichen Leistungsfähigkeit: Literaturübersicht und praktische Beispiele. Österreichisches Journal für Sportmedizin 2003. 144. Smolensky M, Lamberg L. The body clock guide to better health. New York: Henry Holt and Company, 145. Neubauer DN. Sleep problems in the elderly. Am Fam Physician 1999; 59: 2551-8, 2559-60.
146. Knutson KL, Ryden AM, Mander BA, Van Cauter E. Role of sleep duration and quality in the risk and
severity of type 2 diabetes mellitus. Arch Intern Med 2006; 166: 1768-74.
147. Ayas NT, White DP, Al-Delaimy WK, et al. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care 2003; 26: 380-4.
148. Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E. Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol 2005; 99: 2008-19.
149. Vgontzas AN, Zoumakis M, Papanicolaou DA, et al. Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism 2002; 51: 887-
92.
150. Wolkove N, Elkholy O, Baltzan M, Palayew M. Sleep and aging: 1. Sleep disorders commonly found in older people. Cmaj 2007; 176: 1299-304.
151. Wolkove N, Elkholy O, Baltzan M, Palayew M. Sleep and aging: 2. Management of sleep disorders in older people. Cmaj 2007; 176: 1449-54.
152. Joshi S. Nonpharmacologic therapy for insomnia in the elderly. Clin Geriatr Med 2008; 24: 107-19, viii.
153. Van Someren EJ. Circadian rhythms and sleep in human aging. Chronobiol Int 2000; 17: 233-43.
154. Montgomery P, Dennis J. Bright light therapy for sleep problems in adults aged 60+. Cochrane Database
Syst Rev 2002: CD003403.
155. Ayalon L, Gum AM, Feliciano L, Arean PA. Effectiveness of nonpharmacological interventions for the management of neuropsychiatric symptoms in patients with dementia: a systematic review. Arch Intern
Med 2006; 166: 2182-8.
156. Dowling GA, Burr RL, Van Someren EJ, et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J Am Geriatr Soc 2008; 56: 239-46.
157. Megdal SP, Kroenke CH, Laden F, Pukkala E, Schernhammer ES. Night work and breast cancer risk: a systematic review and meta-analysis. Eur J Cancer 2005; 41: 2023-32.
158. Gaylord SA, Williams ME. A brief history of the development of geriatric medicine. J Am Geriatr Soc 1994; 42: 335-40.
159. Strube H. [It is never too late--nutrition in the elderly]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2006; 49: 547-57.
160. Ferrari CK. Functional foods and physical activities in health promotion of aging people. Maturitas 2007; 58: 327-39.
161. Fabian E, Elmadfa I. Nutritional situation of the elderly in the European Union: data of the European Nutrition and Health Report (2004). Ann Nutr Metab 2008; 52 Suppl 1: 57-61.
162. Elmadfa I, Meyer AL. Body composition, changing physiological functions and nutrient requirements of the elderly. Ann Nutr Metab 2008; 52 Suppl 1: 2-5.
163. Snowdon DA, Tully CL, Smith CD, Riley KP, Markesbery WR. Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study. Am J Clin Nutr 2000; 71: 993-8.
164. Speakman JR, Selman C, McLaren JS, Harper EJ. Living fast, dying when? The link between aging and energetics. J Nutr 2002; 132: 1583S-97S.
165. Fraser GE, Shavlik DJ. Ten years of life: Is it a matter of choice? Arch Intern Med 2001; 161: 1645-52.
166. Willcox BJ, Willcox DC, Todoriki H, et al. Caloric restriction, the traditional Okinawan diet, and healthy
aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span.
Ann N Y Acad Sci 2007; 1114: 434-55.
167. Fontana L, Klein S. Aging, adiposity, and calorie restriction. JAMA 2007; 297: 986-94.
168. Heilbronn LK, de Jonge L, Frisard MI, et al. Effect of 6-month calorie restriction on biomarkers of
longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled
trial. Jama 2006; 295: 1539-48.
169. Allard JS, Heilbronn LK, Smith C, et al. In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets. PLoS ONE 2008; 3: e3211.
170. Verdery RB, Walford RL. Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2. Arch Intern Med 1998; 158: 900-6.
171. Martin B, Mattson MP, Maudsley S. Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev 2006; 5: 332-53.
172. Chen D, Guarente L. SIR2: a potential target for calorie restriction mimetics. Trends Mol Med 2007; 13:
173. Kramer AF, Erickson KI, Colcombe SJ. Exercise, cognition, and the aging brain. J Appl Physiol 2006; 101:
174. Oster P, Pfisterer M, Schuler M, Hauer K. [Physical exercise in old age]. Z Gerontol Geriatr 2005; 38 Suppl 1: I10-3.
175. Hollmann W, Struder HK, Tagarakis CV, King G. Physical activity and the elderly. Eur J Cardiovasc Prev Rehabil 2007; 14: 730-9.
176. Tong L, Shen H, Perreau VM, Balazs R, Cotman CW. Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis 2001; 8: 1046-56.
177. Nelson ME, Rejeski WJ, Blair SN, et al. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association.
Med Sci Sports Exerc 2007; 39: 1435-45.
178. Biesalski HK. [Antioxidants - no reason for a reassessment]. Ophthalmologe 2007; 104: 618-9.
179. Siekmeier R, Steffen C, Marz W. [Can antioxidants prevent atherosclerosis?]. Bundesgesundheitsblatt
Gesundheitsforschung Gesundheitsschutz 2006; 49: 1034-49.
180. Sesso HD, Buring JE, Christen WG, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA 2008; 300: 2123-33.
181. Belch J, MacCuish A, Campbell I, et al. The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients
with diabetes and asymptomatic peripheral arterial disease. BMJ 2008; 337: a1840.
182. Sander S, Coleman CI, Patel AA, Kluger J, White CM. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail 2006; 12: 464-72.
183. Rosenfeldt FL, Haas SJ, Krum H, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens 2007; 21: 297-306.
184. Molyneux SL, Young JM, Florkowski CM, Lever M, George PM. Coenzyme q10: is there a clinical role and a case for measurement? Clin Biochem Rev 2008; 29: 71-82.
185. Soja AM, Mortensen SA. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta- analyses of clinical trials. Mol Aspects Med 1997; 18 Suppl: S159-68.
186. Wagner KH, Haber P, Elmadfa I. Thanks to body exercise, getting mobile and being less dependent. Ann Nutr Metab 2008; 52 Suppl 1: 38-42.
187. Meydani SN, Barnett JB, Dallal GE, et al. Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr 2007; 86: 1167-73.
188. Putics A, Vodros D, Malavolta M, Mocchegiani E, Csermely P, Soti C. Zinc supplementation boosts the stress response in the elderly: Hsp70 status is linked to zinc availability in peripheral lymphocytes. Exp
Gerontol 2008; 43: 452-61.
189. Andriollo-Sanchez M, Hininger-Favier I, Meunier N, et al. No antioxidant beneficial effect of zinc supplementation on oxidative stress markers and antioxidant defenses in middle-aged and elderly
subjects: the Zenith study. J Am Coll Nutr 2008; 27: 463-9.
190. Larsson SC, Wolk A. Magnesium intake and risk of type 2 diabetes: a meta-analysis. J Intern Med 2007; 262: 208-14.
191. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB. The role of iron in type 2 diabetes in humans. Biochim Biophys Acta 2008. 192. Lippman SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Jama 2009; 301: 39-51.
193. Vincent JL, Forceville X. Critically elucidating the role of selenium. Curr Opin Anaesthesiol 2008; 21: 148-
194. Bleys J, Navas-Acien A, Guallar E. Serum selenium and diabetes in U.S. adults. Diabetes Care 2007; 30:
195. Canter PH, Ernst E. Ginkgo biloba is not a smart drug: an updated systematic review of randomised clinical trials testing the nootropic effects of G. biloba extracts in healthy people. Hum Psychopharmacol 2007;
22: 265-78.
196. DeKosky ST, Williamson JD, Fitzpatrick AL, et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA 2008; 300: 2253-62.
197. Nah SY, Kim DH, Rhim H. Ginsenosides: are any of them candidates for drugs acting on the central nervous system? CNS Drug Rev 2007; 13: 381-404.
198. Ernst E. The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava. Ann Intern Med 2002; 136: 42-53.
199. Yun TK, Choi SY. Non-organ specific cancer prevention of ginseng: a prospective study in Korea. Int J Epidemiol 1998; 27: 359-64.
200. Vuksan V, Sung MK, Sievenpiper JL, et al. Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-
controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis 2008; 18: 46-56.
201. Sievenpiper JL, Sung MK, Di Buono M, et al. Korean red ginseng rootlets decrease acute postprandial glycemia: results from sequential preparation- and dose-finding studies. J Am Coll Nutr 2006; 25: 100-
7.
202. Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol 2008; 66: 444-50.
203. Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009; 55: 1-99.
204. Mozaffarian D. Fish and n-3 fatty acids for the prevention of fatal coronary heart disease and sudden cardiac death. Am J Clin Nutr 2008; 87: 1991S-6S.
205. Freeman MP, Hibbeln JR, Wisner KL, et al. Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry 2006; 67: 1954-67.
206. Richardson AJ. n-3 Fatty acids and mood: the devil is in the detail. Br J Nutr 2008; 99: 221-3.
207. Lucas M, Asselin G, Merette C, Poulin MJ, Dodin S. Ethyl-eicosapentaenoic acid for the treatment of
psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-
controlled, randomized clinical trial. Am J Clin Nutr 2009; 89: 641-51.
208. van de Rest O, Geleijnse JM, Kok FJ, et al. Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2008; 88: 706-13.
209. van de Rest O, Geleijnse JM, Kok FJ, et al. Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. Neurology 2008; 71: 430-8.
210. Montgomery P, Richardson AJ. Omega-3 fatty acids for bipolar disorder. Cochrane Database Syst Rev 2008: CD005169.
211. Kleine-Gunk B. Resveratrol-ein Polyphenol mit vielfältigen Wirkungen. Frauenarzt 2006; 47. 212. Harikumar KB, Aggarwal BB. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 2008; 7: 1020-35.
213. Milne JC, Lambert PD, Schenk S, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007; 450: 712-6.
214. Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191-6.
215. Wood JG, Rogina B, Lavu S, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004; 430: 686-9.
216. Epelbaum J. Neuroendocrinology and aging. J Neuroendocrinol 2008; 20: 808-11.
217. Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocr Rev 1993; 14:
218. Laron Z. Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity? Mech Ageing Dev 2005; 126: 305-7.
219. Vahl N, Jorgensen JO, Jurik AG, Christiansen JS. Abdominal adiposity and physical fitness are major determinants of the age associated decline in stimulated GH secretion in healthy adults. J Clin
Endocrinol Metab 1996; 81: 2209-15.
220. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled
trial. Jama 2002; 288: 321-33.
221. Heutling D, Lehnert H. [Hormone therapy and menopause]. Dtsch Med Wochenschr 2005; 130: 829-34.
222. Beral V. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003; 362:
223. Beral V, Bull D, Green J, Reeves G. Ovarian cancer and hormone replacement therapy in the Million Women Study. Lancet 2007; 369: 1703-10.
224. Estrogen and progestogen therapy in postmenopausal women. Fertil Steril 2008; 90: S88-102.
225. Farquhar CM, Marjoribanks J, Lethaby A, Lamberts Q, Suckling JA. Long term hormone therapy for
perimenopausal and postmenopausal women. Cochrane Database Syst Rev 2005: CD004143.
226. Emons G. [Hormone therapy with estrogens and gestagens in peri- and post-menopause]. Internist (Berl) 2008; 49: 553-8.
227. Lethaby AE, Brown J, Marjoribanks J, Kronenberg F, Roberts H, Eden J. Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database Syst Rev 2007: CD001395.
228. Hochreiter WW, Ackermann DK, Brutsch HP. [Andropause]. Ther Umsch 2005; 62: 821-6.
229. Zitzmann M. [Therapy of male hypogonadism]. Internist (Berl) 2008; 49: 559-60, 562-4, 566-9.
230. Schreiber G, Ziemer M. The aging male--diagnosis and therapy of late-onset hypogonadism. J Dtsch
Dermatol Ges 2008; 6: 273-9.
231. Mattison JA, Lane MA, Roth GS, Ingram DK. Calorie restriction in rhesus monkeys. Exp Gerontol 2003; 38: 35-46.
232. Heutling D, Lehnert H. [Hormone therapy and anti-aging: is there an indication?]. Internist (Berl) 2008; 49:
233. Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci U S A 2000; 97:
4279-84.
234. Raven PW, Hinson JP. Dehydroepiandrosterone (DHEA) and the menopause: an update. Menopause Int 2007; 13: 75-8.
235. Nair KS, Rizza RA, O'Brien P, et al. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 2006; 355: 1647-59.
236. Huppert FA, Van Niekerk JK. WITHDRAWN: Dehydroepiandrosterone (DHEA) supplementation for cognitive function. Cochrane Database Syst Rev 2006: CD000304.
237. Panjari M, Davis SR. DHEA therapy for women: effect on sexual function and wellbeing. Hum Reprod Update 2007; 13: 239-48.
238. Garnero P, Sornay-Rendu E, Claustrat B, Delmas PD. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res
2000; 15: 1526-36.
239. Ekmekcioglu C. Melatonin receptors in humans: biological role and clinical relevance. Biomed Pharmacother 2006; 60: 97-108.
240. Karasek M. Does melatonin play a role in aging processes? J Physiol Pharmacol 2007; 58 Suppl 6: 105-13.
241. Scholer HR. [The potential of stem cells. A status update]. Bundesgesundheitsblatt Gesundheitsforschung
Gesundheitsschutz 2004; 47: 565-77.
242. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007; 8: 253-
243. Fraga MF, Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet 2007; 23: 413-8.
244. Lu Q, Qiu X, Hu N, Wen H, Su Y, Richardson BC. Epigenetics, disease, and therapeutic interventions.
Ageing Res Rev 2006; 5: 449-67.
245. Mahlknecht U, Hoelzer D. [Epigenetic regulators as novel therapeutic targets in hematology/oncology]. Dtsch Med Wochenschr 2003; 128: 2423-6.
246. McCarrey J. Epigenetik. Gynäkol Endocrinol 2008. 247. Mathers JC. Nutritional modulation of ageing: genomic and epigenetic approaches. Mech Ageing Dev 2006; 127: 584-9.
248. Seo YR, Sweeney C, Smith ML. Selenomethionine induction of DNA repair response in human fibroblasts. Oncogene 2002; 21: 3663-9.
249. Collins AR, Harrington V, Drew J, Melvin R. Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis 2003; 24: 511-5.
250. Pufulete M, Al-Ghnaniem R, Khushal A, et al. Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut 2005; 54: 648-53.
251. Baccini M, Bachmaier EM, Biggeri A, et al. The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation. Genes Nutr 2008; 3: 147-151.
252. Levick SE. From Xenopus to Oedipus: "Dolly," human cloning, and psychological and social "clone-ness". Cloning Stem Cells 2007; 9: 33-9.
253. Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci 2003; 58: 232-7.
254. Rattan SI. The science of healthy aging: genes, milieu, and chance. Ann N Y Acad Sci 2007; 1114: 1-10.
255. Fries JF. Aging, natural death, and the compression of morbidity. 1980. Bull World Health Organ 2002; 80:

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